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Treatment with azathioprine within 3 months of remission induction with cyclophosphamide is a common treatment strategy for patients with ANCA-associated vasculitis. This study comprised patients undergoing long-term follow-up who were randomly allocated to azathioprine after 3-6 months or after 12 months of cyclophosphamide treatment.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Patients fro
Among the parameters to take into account in the design of a proton exchange membrane fuel cell (PEMFC), the energy conversion efficiency and material cost are very important. Understanding in deep the behavior and properties of functional layers at the microscale is helpful for improving the performance of the system and find alternative materials. The functional layers of the PEMFC, i.e., the ga
In veal calf production, growth promoters are still illicitly used. Surveillance of misuse of such molecules is necessary to preserve human health. Methods currently adopted for their analysis are based on liquid chromatography tandem mass spectrometry, but their efficacy can be affected by undetectable residual concentrations in biological matrices due to treatments at low-dosage or based on unkn
In a typical fish eye, the crystalline lens is the only refractive element. It is spherical in shape and has high refractive power. Most fish species have elaborate color vision and spectral sensitivity may range from the near-infrared to the near-ultraviolet. Longitudinal chromatic aberration exceeds depth of focus and chromatic blur is compensated for by species-specific multifocality of the len
Background: Psychotic illness can have a substantial economic burden not only on the patient and society in general, but also on family members providing informal care (i.e. those not subject to a market wage). While informal caregiving confers benefits for the patient and society, time spent providing informal care is diverted from other activities such as work or leisure. Relatives and caregiver
Welders are at risk for cardiovascular disease. Recent studies linked tobacco smoke exposure to hypomethylation of the F2RL3 (coagulation factor II (thrombin) receptor-like 3) gene, a marker for cardiovascular disease prognosis and mortality. However, whether welding fumes cause hypomethylation of F2RL3 remains unknown.
Here we will briefly describe the commissioning of the Double ElectroStatic Ion Ring ExpEriment (DESIREE) facility at Stockholm University, Sweden. This device uses purely electrostatic focussing and deflection elements and allows ion beams of opposite charge to be confined under extreme high vacuum and cryogenic conditions in separate "rings" and then merged over a common straight section. This a
The escape process from the native valley for proteins subjected to a constant stretching force is examined using a model for a beta barrel. For a wide range of forces, the unfolding dynamics can be treated as one-dimensional diffusion, parametrized in terms of the end-to-end distance. In particular, the escape times can be evaluated as first passage times for a Brownian particle moving on the pro
Memory T cells present a unique challenge in transplantation. Although memory T cells express robust immune responses to invading pathogens. they may be resistant to the effects of immunosuppressive therapies used to prolong graft survival. In previous studies, we found that compound K. the synthesized analogue of highly unsaturated fatty acids from Isatis tinctoria L., reduced acute cardiac allog
In this Monte Carlo simulation study we use mesoscopic modeling to show that beta-casein, an unstructured milk protein, adsorbs to surfaces not only due to direct electrostatic and hydrophobic interactions but also due to structural rearrangement and charge regulation due to proton uptake and release. beta-casein acts as an amphiphilic chameleon, changing properties according to the chemical envir
The sex pheromone of the cloaked pug moth, Eupithecia abietaria Götze, an important cone-feeding pest in spruce seed orchards in Europe, was investigated. Chemical and electrophysiological analyses of pheromone gland extracts of female moths and analogous analyses of synthetic hydrocarbons and epoxides of chain length C19 and C21 revealed (3Z,6Z,9Z)-3,6,9-nonadecatriene (3Z,6Z,9Z-19:H) and 3Z,6Z-c
Using basic ecological concepts, we introduce sperm ecology as a framework to stud sperm cells. First, we describe environmental effects on sperm and conclude that evolutionary and ecological research should not neglect the overwhelming evidence presented here (both in external and internal fertilizers and in terrestrial and aquatic habitats) that sperm function is altered by many environments, in
Radiative lifetimes of 7 odd and 11 even parity states of Tb I (Z = 65) have been measured by the time resolved laser induced fluorescence method (TR-LIF). Experimental data for 9 out of the 18 states are obtained for the first time. The radiative lifetimes presented in this study are in good agreement with previous TR-LIF experimental results but systematically shorter than those obtained by the
Twenty-three isolates of Colletotrichum gloeosporioides, five isolates of C. acutatum, two isolates of C. capsici and six isolates of C. boninense associated with anthracnose disease on coffee (Coffea spp.) in Vietnam were identified based on morphology and DNA analysis. Phylogenetic analysis of DNA sequences from the internal transcribed spacer region of nuclear rDNA and a portion of mitochondria
Apomorphine as subcutaneous injections offers a valuable and effective treatment alternative for Parkinson patients with oral medication-resistant "off' phases. Its efficacy is stable during long-term therapy, with no signs of patient tolerance. Adverse events are usually mild. The best results are obtained with relatively young, active, and cognitively intact patients. Intermittent s.c. apomorphi
To evaluate the accuracy of different methods used to identify individuals with increased risk of developing coronal dental caries.
We describe an algorithm for improving subsequent parton shower emissions by full SU(3) color correlations in the framework of a dipole-type shower. As a proof of concept, we present results from the first implementation of such an algorithm for a final state shower. The corrections are found to be small for event shapes and jet rates but can be more significant for tailored observables.
Abstract in UndeterminedThe properties of the single-link multiple-input-multiple- output (MIMO) propagation channels have been analyzed in many studies based on extensive propagation measurements. In this letter, we extend the measurement-based analysis to dual-link MIMO propagation channels. Here, we examine interlink correlation by evaluating the correlation of eigenvectors obtained from multip
Accumulating studies, both in animals and human clinical trials with mesenchymal stroma cells (MSC) support the hypothesis of therapeutic effects of these cells in various disorders. However, despite success in immune-mediated disorders such as Crohns' disease, lung disorders such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary disease (IPF) treated with MSC have so far no
Data from four soil profiles studied through pollen and macroscopic charcoal analyses were used to identify specific palynological assemblages associated with a traditional land-use system documented in the Eastern Ligurian Apennines (NW Italy) between the 18th and early 20th century, concerning a cyclical use of grey alder plots for temporary cultivations involving to the use of controlled fire.
