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Metabolic reprogramming is critical during clear cell renal cell carcinoma (ccRCC) tumorigenesis, manifested by accumulation of lipid droplets (LDs), organelles that have emerged as new hallmarks of cancer. Yet, regulation of their biogenesis is still poorly understood. Here, we demonstrate that MYC inhibition in ccRCC cells lacking the von Hippel Lindau (VHL) gene leads to increased triglyceride
The production of the ψ(2S) charmonium state was measured with ALICE in Pb-Pb collisions at √sNN=5.02 TeV, in the dimuon decay channel. A significant signal was observed for the first time at LHC energies down to zero transverse momentum, at forward rapidity (2.5
The first measurements of K∗(892)0 resonance production as a function of charged-particle multiplicity in Xe-Xe collisions at sNN=5.44 TeV and pp collisions ats=5.02 TeV using the ALICE detector are presented. The resonance is reconstructed at midrapidity (|y| < 0.5) using the hadronic decay channel K∗0 →K±π∓. Measurements of transverse-momentum integrated yield, mean transverse-momentum, nuclear
Background: Pesticide exposure may affect young children's neurodevelopment, but only few cohort studies have addressed possible effects of non-organophosphate pesticides. Objective: We evaluated associations between prenatal current-use pesticide exposure and neurodevelopmental outcomes among 1-year-old children from the Infants’ Environmental Health (ISA) birth cohort. Methods: To determine pren
The inclusive top-quark-pair production cross section σtt¯ and its ratio to the Z-boson production cross section have been measured in proton–proton collisions at s=13.6 TeV, using 29 fb−1 of data collected in 2022 with the ATLAS experiment at the Large Hadron Collider. Using events with an opposite-charge electron-muon pair and b-tagged jets, and assuming Standard Model decays, the top-quark-pair
On December 5, 2022, an indirect drive fusion implosion on the National Ignition Facility (NIF) achieved a target gain Gtarget of 1.5. This is the first laboratory demonstration of exceeding "scientific breakeven"(or Gtarget>1) where 2.05 MJ of 351 nm laser light produced 3.1 MJ of total fusion yield, a result which significantly exceeds the Lawson criterion for fusion ignition as reported in a pr
The mass of the Higgs boson is measured in the H→γγ decay channel, exploiting the high resolution of the invariant mass of photon pairs reconstructed from the decays of Higgs bosons produced in proton–proton collisions at a centre-of-mass energy s=13 TeV. The dataset was collected between 2015 and 2018 by the ATLAS detector at the Large Hadron Collider, and corresponds to an integrated luminosity
What constraints and conditions are conducive to the innovation of more advanced watercraft technology? This paper explores this question by modeling ancient voyages in the Channel Island region of southern California. The Chumash and Tongva cultures of this region invented an advanced form of boat, the sewn plank canoe, around 500 CE. This new technology led to a rapid increase in maritime travel
Background: In patients undergoing resection for pancreatic cancer, adjuvant modified fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) improves overall survival compared with alternative chemotherapy regimens. We aimed to compare the efficacy and safety of neoadjuvant FOLFIRINOX with the standard strategy of upfront surgery in patients with resectable pancreatic ductal adenocarci
This letter reports the observation of W(ℓν)γγ production in proton-proton collisions. This measurement uses the full Run 2 sample of events recorded at a center-of-mass energy of s=13 TeV by the ATLAS detector at the LHC, corresponding to an integrated luminosity of 140 fb−1. Events with a leptonically-decaying W boson and at least two photons are considered. The background-only hypothesis is rej
The purpose of this paper is to analyse the evolution of Qatar and the UAE’s foreign aid and compare them in the same context: the Syrian early recovery. Analysing data on projects financed as well as the geographical, sectoral, and channel allocation of aid, the article highlights crucial aspects of these two Gulf donors’ behaviours. To examine their modus operandi, this research focuses on the S
This article compares two Islamic organisations, a non-governmental and a national one, in their methods of collecting and distributing zakat, and analyses how they addressed the COVID-19 crisis with these funds in the period 2020–2021. The study examines Islamic Relief as a Muslim non-governmental organisation involved in humanitarian response, and the National Board of the Zakat Republic of Indo
Context. TOI-732 is an M dwarf hosting two transiting planets that are located on the two opposite sides of the radius valley. Inferring a reliable demographics for this type of systems is key to understanding their formation and evolution mechanisms. Aims. By doubling the number of available space-based observations and increasing the number of radial velocity (RV) measurements, we aim at refinin
Background: The COVID-19 pandemic adversely affected health care systems. Patients in need of transcatheter aortic valve replacement (TAVR) are especially susceptible to treatment delays. Objectives: This study sought to evaluate the impact of the COVID-19 pandemic on global TAVR activity. Methods: This international registry reported monthly TAVR case volume in participating institutions prior to
Purpose: This article reports on jaw articulation, in connection with the segmental articulations of tongue tip and lips. The jaw is considered a syllable articulator as it opens and closes for each syllable, and the amount of jaw opening is related to syllable strength, given the same phonemic vowel. Here, we investigate the syllabic and the segmental articulations relationships to the acoustic s
Blomväxterna, eller angiospermerna som de kallas i vetenskapliga sammanhang, omfattar idag över 295 000 olika arter. Men denna siffra ändras ständigt eftersom det beskrivs ungefär 2 000 nya arter varje år. För att kunna ha överblick över en så stor mängd behöver den organiseras på ett vettigt sätt. Det har botanister försökt med alltsedan Linnés tid.
Charles Darwin (1809–1882) är främst känd för sin evolutionsteori– om arters utveckling genom naturligt urval. Hans övriga arbetenär mindre kända. Mycket handlade om växter – om mekanismer för pollinering, blombiologi, rörelser och förmågan att ta upp näring från andra organismer – sådant som intresserat honom sedan studietiden i Cambridge. Med tiden kom han att publicera ett flertal böcker och en
