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Traumatic brain injury (TBI) is one of leading causes of death in the world; survivors commonly exhibit behavioural changes and neurocognitive defects in the long-term. Following TBI, rapid changes in the neurovascular unit (NVU) occur as the permeability of the blood brain barrier (BBB) increases and cerebral blood flow (CBF) becomes dysregulated. An integral component of the NVU are pericytes wh
Acute myeloid leukemia (AML) is one of the most common and deadliest form of blood cancer in adults, accounting for over 80% of acute leukemic diagnoses. Despite the introduction of new targeted therapies, survival rate remains low in adults, and new therapeutic approaches are needed. In a previous CRISPR screen performed by the Järås group, CALRETICULIN was identified as a regulator of human leuc
The unicellular green alga of genus Chlamydomonas are well studied within the fields of photosynthesis and flagellar research. Although many molecular tools have been developed for use on Chlamydomonas, little research has been done on its ecology and population dynamics. Species within the genus are morphologically indistinguishable using light microscopy and as such a molecular method is necessa
Neuroblastoma is pediatric cancer of the sympathetic nervous system which originates from the trunk neural crest cell population during embryonic development. Clinical representation of neuroblastoma ranges from a spontaneous regression to metastatic disease with only about 50% survival rate. Molecular events which turn normal development of sympathetic nervous system to tumorigenic has not been f
Immunotherapy utilizes the patient’s own immune system for the treatment of cancer. Due to exceptional antigen-presentation capacity Dendritic Cells (DCs) have great potential for cancer immunotherapy. Using direct cellular reprogramming our group has identified a combination of transcription factors, PU.1, IRF8, and BATF3 that reprograms mouse and human fibroblasts and a range of cancer cell line
Bakgrund: Det är vanligt att barn upplever rädsla i samband med besök i hälso- och sjukvården och vid medicinska procedurer. Upp till 45% av barn i åldern 4–6 år känner svår ångest under vaccinering vilket belyser deras oro av nålar och vården. Erfarenheter i form av rädsla, smärta och oro i och vid sjukvårdsbesök kan ha långsiktiga konsekvenser för barnet och i vissa fall kan det leda till nålfob
Since a large growth in population occurred during the 1800-1900 centuries in Sweden, an expansion of agricultural land became a necessity. The government provided farmers with an allowance to exploit wetlands. A large portion of wetlands has since then been lost and used for cultivation, in particular peat lands. The drainage of peat lands results in a loss in biodiversity, poorer water condition
Democracy is a broad and complicated concept with numerous interpretations. To determine people's actual desire for democracy, we must first understand the concept they have in mind. By conducting qualitative interviews with open-ended questions, this study aims to study the in-depth meanings behind the concept of democracy among the young people in Kazakhstan. This study uses an interpretive
Acoustophoresis is a cell separation technology where particles or cells are suspended in a fluid container and subject to acoustic standing waves. The standing waves exerts an acoustic radiation force on the particles, pushing them towards the nodal plane. This movement is called migration, and the migration velocity depends on the acoustic mobility of the particle, which depend on the particle s
Chemicals are becoming more and more important and almost essential for human life. Therefore, the human exposure of hazardous chemicals has increased substantially. Alternative assessment (AA) is a method used for substitution of hazardous chemicals and requirements for substitution are included in European health and safety legislation. As part of Region Kalmar läns environmental and sustainabil
The aim of this project is to design a solution to a payment system for people that have a diagnosis of intellectual disorder. This target group has problems with today’s payment system because it becomes successively more digital. With the digital solutions will the target group be excluded. I have been thinking of the question “What would happen if cash was removed as a payment system?”. I have
In addition to its complex structure, the cerebral cortex has multiple functions exclusive to humans. Unfortunately, it also plays a crucial role in multiple neurodevelopmental and psychiatric disorders. Although we know very little about human-specific gene regulatory mechanisms during brain development, non-coding RNAs are evolutionarily non-conserved, evolve faster, and are highly expressed in
