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Cellular proteins are subject to frequent methylation on lysine residues, introduced by specific methyltransferases, and each lysine residue can receive up to three methyl groups. Histone methylations, which are key determinants of chromatin state and transcriptional status, have been subject to particularly intense studies, but methylations on non-histone protein substrates are also abundant and
The human methyltransferases (MTases) METTL21A and VCP-KMT (METTL21D) were recently shown to methylate single lysine residues in Hsp70 proteins and in VCP, respectively. The yet uncharacterized MTase encoded by the YNL024C gene in Saccharomyces cerevisiae shows high sequence similarity to METTL21A and VCP-KMT, as well as to their uncharacterized paralogues METTL21B and METTL21C. Despite being most
The components of the cellular protein translation machinery, such as ribosomal proteins and translation factors, are subject to numerous post-translational modifications. In particular, this group of proteins is frequently methylated. However, for the majority of these methylations, the responsible methyltransferases (MTases) remain unknown. The human FAM86A (family with sequence similarity 86) p
Hsp70 proteins constitute an evolutionarily conserved protein family of ATP-dependent molecular chaperones involved in a wide range of biological processes. Mammalian Hsp70 proteins are subject to various post-translational modifications, including methylation, but for most of these, a functional role has not been attributed. In this study, we identified the methyltransferase METTL21A as the enzym
Valosin-containing protein (VCP, also called p97) is an essential and highly conserved adenosine triphosphate-dependent chaperone implicated in a wide range of cellular processes in eukaryotes, and mild VCP mutations can cause severe neurodegenerative disease. Here we show that mammalian VCP is trimethylated on Lys315 in a variety of cell lines and tissues, and that the previously uncharacterized
This study closely examines long-term outcomes of intermarriage in Denmark in terms of children’s educational performance, studying grades from final examinations. The study uses rich register data, where families are linked across generations, and contributes to the migration literature by providing new insights into the human capital formation in inter-ethnic families. The outcomes of children o
Commodity prices and their secular trends are at the core of many different development theories, particularly relevant for the Latin American region, like the Prebisch-Singer hypothesis, the natural resource curse theory or the somehow malthusian scarcity prediction. In this article we review the international copper price indices available in the literature and we compare them with a new data se
The Arctic has warmed more than twice as fast as the global average since the late twentieth century, a phenomenon known as Arctic amplification (AA). Recently, there have been considerable advances in understanding the physical contributions to AA, and progress has been made in understanding the mechanisms that link it to midlatitude weather variability. Observational studies overwhelmingly suppo
This doctoral dissertation comprises three independent essays on information transmission and crisis spillover in the financial markets. The research questions are examined in the context of the foreign exchange market, the stock market and the global banking system.The first paper, The Response of Exchange Rates to Central Bank Communication: A Textual Analysis Approach, investigates how European
In this paper I discuss the challenge of visualising ongoing and repeated state violence and impunity in Thailand. Human rights activists commonly assume that photographs hold political power. This assumption can be doubted. Even if there are material traces of the violence, they cannot guarantee visibility, and, as Ariella Azoulay points out, photography of violence risks depoliticizing by equati
This study utilizes recently published environmental extensions to the World Input–Output Database (WIOD) to compare production-based, consumption-based and technology-adjusted carbon emissions for 44 countries and country groups for the period 2000 to 2014. Results show some significant shifts in global emission trends compared to similar studies of the period before 2009. For 20 European Union (
According to a popular view, religious fictionalism requires the atheist subject to have independent motivation/justification for all of her religious actions. I challenge this view and argue that all that is needed is a holistic justification of the subject's fictionalist engagement with religion.
