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We performed a genome-wide association study of melanoma in a discovery cohort of 2,168 Australian individuals with melanoma and 4,387 control individuals. In this discovery phase, we confirm several previously characterized melanoma-associated loci at MC1R, ASIP and MTAP-CDKN2A. We selected variants at nine loci for replication in three independent case-control studies (Europe: 2,804 subjects wit
Local research units. this article argues, play a very important role for the scientific field they belong to, for example by mobilizing financial support, offering job opportunities, attracting talented recruits, and providing adequate training. Little is known, however, about such units, at least in the fields under study here, i.e., studies of innovation, entrepreneurship and related phenomena.
Popular Abstract in Swedish Det finns ett flertal hormoner som bildas i mag-tarmkanalen och som sedan frisätts till blodet i samband med måltidsintag. Runtom i kroppen finns det sedan målceller, så kallade receptorer, som stimuleras av hormonerna till att påverka olika processer i kroppen. De hormoner från mag-tarmkanalen som vi har studerat är de så kallade inkretinhormonerna, glukagon-lik peptidSeveral different hormones are released from the intestine following a meal. In this thesis we have focused on the so called incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). An important function of the incretin hormones is potentiation of insulin release from pancreatic beta-cells following a meal. This property has attracted a lot of inte
Objectives. To study treatment response rates of RA patients undergoing second- and third-line anti-TNF therapy and to identify baseline predictors of response to second-line treatment. Methods. RA patients monitored in a prospective, observational study, having switched anti-TNF therapy once (first-time switchers, n = 337) or twice (second-time switchers, n = 36)-i.e. following failures with one
A literature study is performed to compile the state-of-the-art, as well as future potential, in SOFC modeling. Principles behind various transport processes such as mass, heat, momentum and charge as well as for electrochemical and internal reforming reactions are described. A deeper investigation is made to find out potentials and challenges using a multiscale approach to model solid oxide fuel
I detta kapitel problematiseras hur skolpersonal och representanter för myndigheter av betydelse för ungdomars försörjning och arbetsmarknadsetablering reflekterar kring gymnasiestudier med fokus på yrkes- och lärlingsutbildning.
An on-road study was conducted to evaluate a complementary tactile navigation signal on driving behaviour and eye movements for drivers with hearing loss (HL) compared to drivers with normal hearing (NH). 32 participants (16 HL and 16 NH) performed two preprogrammed navigation tasks. In one, participants received only visual information, while the other also included a vibration in the seat to gui
I denna studie analyseras muntliga etnicitetsgestaltningar hos olika aktörer i ungdomsvården. Undersökningen uppmärksammar etniciteten när den uttrycks verbalt och icke-verbalt, hur den uttrycks samt i vilka situationer kategoriseringar synliggörs implicit eller explicit. Studiens syfte är: att analysera när och hur etnicitet aktualiseras genom kategoriseringar i ungdomsvården, att uppmärksamma hThe aim of this study is to analyze when and how ethnicity is actualised through categorisations in Swedish youth-care, to attract attention to how these categorisations are indicated and point out how the narrators own ethnic identity is shaped and upheld through different markings. The report is based on 109 interviews conducted with different actors in the youth-care and my field-notes made in
Towns and cities have always been sites of attraction not only as centers of trade and commerce, seats of administration and power centers but also providing facilities for health and education. This is especially true of post-colonial nations such as India, marking differences between rural and urban areas in many significant ways. The late colonial and early post-colonial periods experienced wid
En kärnfråga i miljömålsarbetet rör hur miljömålen kan respektive bör användas vid tillämpningen av miljöbalkens olika styrmedel. Rapporten redogör för olika aktörers erfarenheter och åsikter i dessa frågor. Forskningen bygger på djupintervjuer med personer inom bland annat kommuner, länsstyrelser, miljödomstolar och näringslivet. Fokus ligger på två styrmedel: tillstånd till miljöfarlig verksamhe
Colorectal cancer (CRC) is the third most common cancer worldwide with more than 700,000 deaths every year. Prognosis mostly depends on disease stage at diagnosis, however, outcome may vary considerably even within the same stage. Thus, there is a great need for new prognostic biomarkers to better identify patients with a high risk of developing metastases and select right patients for adjuvant tr
Many patients on renal replacement therapy (RRT) require parathyroidectomy (PTX). Trends and current rates of PTX on a national level are not known. Furthermore, it is not completely clear which factors influence rates of PTX. Thus, our aim was to investigate the incidence, regional distribution and factors associated with PTX as well as possible temporal changes, in the Swedish RRT population.
BACKGROUND: Tuberculosis causes significant morbidity and mortality worldwide, especially in sub-Saharan Africa. DC-SIGN, encoded by CD209, is a receptor capable of binding and internalizing Mycobacterium tuberculosis. Previous studies have reported that the CD209 promoter single nucleotide polymorphism (SNP)-336A/G exerts an effect on CD209 expression and is associated with human susceptibility t
In modern standard Swedish genitive is marked by -s, which, according to the standard analyses, is a phrasal clitic, viz. [mannen på gatan]s åsikt (man on street-s opinion). In dialects in parts of Småland, Halland, and Västergötland a variant on -a or -e, here called a-genitive, is used, primarily on proper names, viz. Erik-a bil (Erik-gen car) ‘Erik’s car’, a form that should be compared to the
This paper presents a technique for reconstructing two interfering wavefronts by analyzing their 3D interference field pattern. The method is based on the numerical inverse problem and will present a robust algorithm for reconstructing of wavefronts. Several simulations are done to validate the proposed method. (C)2011 Optical Society of America
