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Periampullary adenocarcinoma, including pancreatic cancer, is a heterogeneous group of tumours with dismal prognosis, for which there is an urgent need to identify novel treatment strategies. The human epithelial growth factor receptors EGFR, HER2 and HER3 have been studied in several tumour types, and HER-targeting drugs have a beneficial effect on survival in selected types of cancer. However, t
Atypical femoral fractures are insufficiency fractures in the lateral femoral diaphysis or subtrochanteric region that mainly affect older patients on bisphosphonate therapy. Delayed healing is often seen in patients with incomplete fractures (cracks), and histology of bone biopsies shows mainly necrotic material inside the crack. We hypothesized that the magnitude of the strains produced in the s
Technology scaling in advanced CMOS nodes has been very successful in reducing the cost and increasing the operating frequency, however, it has also resulted in reduced transistor intrinsic gain and increased thermal noise coefficient, and most importantly, deteriorated linearity performance. At the same time, advanced wireless communication standards offer ever increasing data rates and pose m
Infrared cameras can be used in science education. The technology suits open-ended thermodynamics laboratory exercises in higher education. School children engage in instant inquiry of thermal phenomena.
This paper draws on two experiences of undertaking comparative research in England,Sweden and Italy, and offers a discussion of the kinds of dilemmas raised in relation tolanguage and meaning surfaced by these. Its primary focus is to examine the reflexiveconstruction of meaning, both in relation generally to the workings of an internationalresearch team and, more specifically, how such constructiThis paper draws on two experiences of undertaking comparative research in England, Sweden and Italy, and offers a discussion of the kinds of dilemmas raised in relation to language and meaning surfaced by these. Its primary focus is to examine the reflexive construction of meaning, both in relation generally to the workings of an international research team and, more specifically, how such constr
Mi’kmaq Indians’ descriptions of journeys between parallel worlds, as we find them in tales collected from the early seventeenth century to the earlier twentieth, are far too complex to fit into Mircea Eliade’s model of shamanism or romantic images of Indians as being “one with nature”. The tales reveal six parallel worlds in which all types of beings belongs to families, have wigwams, and search
Abstract in French Cet article porte sur la manière dont les Micmacs ont lutté contre le projet d'une vaste carrière dans les années 1990 sur l'île du Cap-Breton, Nouvelle-Écosse, en faisant référence à leurs traditions et à leur héros culturel, Kluskap. Tout d'abord, l'auteure explore la manière dont un chasseur micmac canadien et pré-moderne interprète le monde, tel que décrit dans les histoires
It seems that the revitalization of traditional rituals has been an effective way of developing a new embodiment and identity. The ability of the Canadian Mi'kmaq Indians to rework the cultural body, historically imposed on them by the dominant society, opens the way to weeding out destructive patterns unconsciously or consciously embedded historically in their bodies. The ritual opens up opportun
This article aims to examine the dialectic interface between the Canadian Mi’kmaq traditions and Catholicism, the latter brought into their territory by French missionaries as early as the beginning of the 17th century. Although today there have been critical voices raised by some Mi’kmaq against the Catholic church, which they see as a symbol for colonial repression, most Mi’kmaq today belong to
A challenging question today is how to understand and act on climate change. Previous analyses of the public outreach of the climate sciences have concluded that the urgent communication of climate change is inadequate. It is foremost the invisibility of carbon dioxide and the lack of a tangible relationship between current emissions and future effects that have been seen as the main challenge to
The paper offers some reflections on the use of ritual and tradition in contemporary Sweden. The social condition of modernity has radically changed the context of ritual and transformed traditional patterns and new rituals have emerged that respond to these contemporary societal structures. It presents some new practices, discusses different categories of new ritual mastery and investigates the i
This paper describes the development of St Anne's festival, celebrated by the Mi'kmaq each year for centuries. It is a case study of a "space" where Indian traditions and Christianity btought by Catholic missionaries meet, clash and merge.
OBJECTIVES: To investigate exposure-response relationships between measured movements and postures of the wrist and the incidence of carpal tunnel syndrome (CTS), and any modifications by sex.METHODS: In 2011, we established a historical cohort of 9364 members of the Painters' Union in Denmark. Self-reported task distributions were obtained by questionnaire (53% responded) and combined with sex-sp
As the evolutionary responses to environmental change depend on selection acting on individual differences,disentangling within- and between-individual variation becomes imperative. In animalmigration research, multiyear tracks are thus needed to estimate the individual consistency of phenotypictraits. Avian telemetry studies have recently provided the first evidence of individuality acrossspace a
BACKGROUND: Endocrine resistance is a major obstacle to optimal treatment effect in breast cancer. Some genetic markers have been proposed to predict response to aromatase inhibitors (AIs) but the data is insufficient. The aim of the study was to find new genetic treatment predictive markers of AIs.METHODS: The ongoing population-based BC-blood study in Lund, Sweden includes women with primary bre
Background and purpose - Assessment of potential disparities in access to care is a vital part of achieving equity in health and healthcare. We have therefore studied the effect of socioeconomic status (SES) on the rates of knee and hip replacement due to osteoarthritis. Methods - This was a cohort study in Skåne, Sweden. We included all residents aged ≥ 35 years with consultations between 2004 an
Vestibular asymmetry is a common cause of dizziness in the elderly, for whom it precipitates the risk of falling. Previous studies have shown that those with vestibular asymmetry displayed an altered variability in double support time (DST) compared to controls. However, swing time (SwT) variability findings are conflicting. In this study, we investigated if vestibular asymmetry might be causally
This article proposes a critical legal analysis of the jurisprudence of the Inter-American Court of Human Rights regarding indigenous peoples’ rights to lands, participation, and consultation. It focuses on the role that cultural diversity as a legal standard has played in the recognition of the indigenous peoples’ right to consultation and participation in all matters that directly affect them, a
