Filtyp
Erlotinib inhibits epithelial growth factor receptor (EGFR) kinase activity and is used to treat non-small cell lung cancer (NSCLC). Despite its high efficacy, recurrence can occur in patients who become resistant to the drug. To address the underlying mechanism of Erlotinib resistance, we investigated additional mechanisms related to mode-of-drug-action, by multiple protein-binding interactions,
OBJECTIVE The authors aimed to develop the first clinical grading scale for patients with surgically treated spontaneous supratentorial intracerebral hemorrhage (ICH). METHODS A nationwide multicenter study including 401 ICH patients surgically treated by craniotomy and evacuation of a spontaneous supratentorial ICH was conducted between January 1, 2011, and December 31, 2015. All neurosurgical ce
Algoritmer är en bärande del av internets infrastruktur som påverkar allt från vilken musik vi får rekommenderad till oss eller vems inlägg som blir synliga för oss i sociala medier, till mer avgörande beslutsfattande processer i offentlig förvaltning. I den här rapporten presenteras resultatet av en studie som utförts inom ramen för Kungliga bibliotekets projekt Digitalt först med användaren i fo
The GDPR aims at strengthening the rights of data subjects and to build trust in the digital single market. This is manifested by the introduction of a new principle of transparency. It is, however, not obvious what this means in practice: What kind of answers can be expected to GDPR requests citing the right to “meaningful information”? This is the question addressed in this article. Seven insuraThe GDPR aims at strengthening the rights of data subjects and to build trust in the digital single market. This is manifested by the introduction of a new principle of transparency. It is, however, not obvious what this means in practice: What kind of answers can be expected to GDPR requests citing the right to “meaningful information”? This is the question addressed in this article. Seven insura
Theories based on optimal sampling by the retina have been widely applied to visual ecology at the level of the optics of the eye, supported by visual behaviour. This leads to speculation about the additional processing that must lie in between-in the brain itself. But fewer studies have adopted a quantitative approach to evaluating the detectability of specific features in these neural pathways.
Biological visual systems provide excellent examples of robust target detection and tracking mechanisms capable of performing in a wide range of environments. Consequently, they have been sources of inspiration for many artificial vision algorithms. However, testing the robustness of target detection and tracking algorithms is a challenging task due to the diversity of environments for application
Many computer vision tasks require the implementation of robust and efficient target tracking algorithms. Furthermore, in robotic applications these algorithms must perform whilst on a moving platform (ego motion). Despite the increase in computational processing power, many engineering algorithms are still challenged by real-Time applications. In contrast, lightweight and low-power flying insects
Classical biomonitoring techniques have focused primarily on measures linked to various biodiversity metrics and indicator species. Next-generation biomonitoring (NGB) describes a suite of tools and approaches that allow the examination of a broader spectrum of organizational levels—from genes to entire ecosystems. Here, we frame 10 key questions that we envisage will drive the field of NGB over t
Successfully predicting the future states of systems that are complex, stochastic, and potentially chaotic is a major challenge. Model forecasting error (FE) is the usual measure of success; however model predictions provide no insights into the potential for improvement. In short, the realized predictability of a specific model is uninformative about whether the system is inherently predictable o
One feature of global change is that biota must respond not to single, but to multiple environmental drivers. By growing a model photosynthetic microbe in environments containing between one and eight different drivers, including changes in CO 2, temperature, and pH, in different combinations, we show that the number as well as the identities of drivers explain shifts in population growth rates. T
Gene flow in macroalgal populations can be strongly influenced by spore or gamete dispersal. This, in turn, is influenced by a convolution of the effects of current flow and specific plant reproductive strategies. Although several studies have demonstrated genetic variability in macroalgal populations over a wide range of spatial scales, the associated current data have generally been poorly resol
Climate change is altering aquatic environments in a complex way, and simultaneous shifts in many properties will drive evolutionary responses in primary producers at the base of both freshwater and marine ecosystems. So far, evolutionary studies have shown how changes in environmental drivers, either alone or in pairs, affect the evolution of growth and other traits in primary producers. Here, we
The growing interest in using population balance modeling to describe emulsification processes has spurred an interest in experimentally measuring the breakup frequency. This contribution classifies, compares, and critically reviews the different methods that have been suggested for measuring the breakup frequency, applicable to emulsification devices. Two major approaches can be seen in previous
Right atrial thrombosis is a rare, but potentially serious complication of acute lymphoblastic leukemia treatment. We conducted a retrospective multicenter study to assess the incidence, treatment, and outcome of asymptomatic right atrial thrombosis detected at routine echocardiography of children after acute lymphoblastic leukemia treatment in the Nordic and Baltic countries. Eleven (2.7%, 95% co
