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Sveriges totalförsvar står inför ett behov av snabb återuppbyggnad. Det försämrade säkerhetspolitiska läget i Europa, i kombination med ökade och mer komplexa risker för störningar i samhällskritiska funktioner, har gjort detta arbete allt viktigare. Behovet av att säkra tillgången på varor och tjänster som är avgörande för befolkningens överlevnad och samhällets funktionalitet vid kriser och krig
Background In patients with stage III cutaneous melanoma, adjuvant treatments with PD-1 and BRAF+MEK inhibitors were approved based on improved recurrence-free survival. However, as the treatments have significant side effects and costs, the effect on overall survival remains a matter of great importance. Methods Clinical and histopathological parameters were obtained from the Swedish Melanoma Reg
Blood biomarkers have emerged as accurate tools for detecting Alzheimer’s disease (AD) pathology, offering a minimally invasive alternative to traditional diagnostic methods such as imaging and cerebrospinal fluid (CSF) analysis. Yet, the logistics surrounding venipuncture for blood collection, although considerably simpler than the acquisition of imaging and CSF, require precise processing and st
Background: Tumor multiplicity is a negative prognostic factor in intrahepatic cholangiocarcinoma (iCCA) and the role of surgical resection in multiple iCCA remains unclear. Patients and Methods: Data were extracted from the Swedish quality registry for cancers of the liver and biliary tract, for all patients undergoing surgery for iCCA (2010–2021). Validation was performed with all Swedish hepato
When designing novel technology, many of the important design decisions tend to be taken early in the process, which is also when it is usually easier to modify the design. Thus, it is important to learn as much as possible, as early as possible in any design process. This work is carried out within the EU project ABILITY, which aims at developing novel refreshable tactile displays. Previously, we
BACKGROUND: Trigger finger surgery typically has a successful outcome, also in patients with diabetes mellitus (DM). However, the impact of glycemic control on long-term outcomes after open trigger finger release (OTFR) remains unclear. This study examines whether high hemoglobin A1c (HbA1c) levels affect patient-reported outcome (PRO) following OTFR in individuals with type 1 diabetes mellitus (T
INTRODUCTION: Stroke is a leading cause of death and disability worldwide. Recurrent strokes are seven times more lethal than initial ones, with 54% leading to long-term disability. Substantial recurrent stroke risk disparities exist among ancestral groups. Notably, Africans face double the risk and higher fatality rates compared to Europeans. Although genetic studies, particularly GWAS, hold prom
BACKGROUND: The urethral wall consists of layers of striated muscle, circular and longitudinal smooth muscles, collagen fibers, and a vascular plexus. However, the relative contributions of these components to urethral pressure in humans remain poorly understood. The circular and longitudinal smooth muscle components can develop a spontaneous contractile activity, generating a basal tone. They can
Acquired inhibitors of blood coagulation are rare but of clinical importance. Prothrombin is a vitamin K-dependent protein, and acquired antibodies toward prothrombin are often associated with the presence of lupus anticoagulant. We describe a previously healthy 70-year-old man presenting with both hemorrhage and thrombosis as well as a prolonged prothrombin time. At arrival at the hospital, he wa
This thesis aimed to develop an understanding that could simplify the developmentof "ready-to-use peanut (Arachis hypogaea L.) sauce commonly consumed in Mozambique,where traditional preparation requires extensive cooking (5-6 hours). The study investigatesthe effects of cooking time on phenolic compounds, sensory properties, and the impact ofdifferent drying methods and dextrin on the sauce's mic
Digital technologies have revolutionized the manufacturing landscape, enhancing productivity, quality, and sustainability. Industry 5.0 emphasizes human–machine collaboration to achieve the Sustainable Development Goals (SDGs) while prioritizing human centrality in technologically advanced systems. Therefore, Industry 5.0 signifies a paradigm shift from techno-centric to human-centric systems to a
A search for T and Y vector-like quarks produced in proton-proton collisions at a centre-of-mass energy of 13 TeV and decaying into Wb in the fully hadronic final state is presented. The search uses 139 fb−1 of data collected by the ATLAS detector at the LHC from 2015 to 2018. The final state is characterised by a hadronically decaying W boson with large Lorentz boost and a b-tagged jet, which are
Differential measurements of Higgs boson production in the τ-lepton-pair decay channel are presented in the gluon fusion, vector-boson fusion (VBF), VH and tt¯H associated production modes, with particular focus on the VBF production mode. The data used to perform the measurements correspond to 140 fb−1 of proton-proton collisions collected by the ATLAS experiment at the LHC. Two methods are used
This paper reports the measurement of Higgs boson production in association with a tt¯ pair in the H→bb¯ decay channel. The analysis uses 140 fb-1 of 13 TeV proton–proton collision data collected with the ATLAS detector at the Large Hadron Collider. The final states with one or two electrons or muons are employed. An excess of events over the expected background is found with an observed (expected
BACKGROUND/OBJECTIVE: Bone remodeling is a critical process for skeletal health, and its dysregulation can lead to diseases like osteoporosis. While several Cyclin-Dependent Kinases (CDKs) are known to regulate bone metabolism, the function of CDK10 remains uncharacterized in this context. Human mutations in CDK10 cause the Al Kaissi syndrome, which involves severe skeletal defects, suggesting a
A search is performed for light, spin-0 bosons decaying into two photons in the 66 to 110 GeV mass range, using 140 fb−1 of proton-proton collisions at s = 13 TeV produced by the Large Hadron Collider and collected by the ATLAS detector. Multivariate analysis techniques are used to define event categories that improve the sensitivity to new resonances beyond the Standard Model. A model-independent
Cities worldwide face immense challenges in transitioning to a sustainable future. While being structurally and politically bound to continuous growth, the striving for a constant increase in production and consumption puts enormous pressure on our planet and its ecosystems. Degrowth has been proposed as a pathway to solving this dilemma. Although scholarly attention to urban degrowth has expanded
This paper presents measurements of top-antitop quark pair (tt¯) production in association with additional b-jets. The analysis utilises 140 fb−1 of proton–proton collision data collected with the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV. Fiducial cross-sections are extracted in a final state featuring one electron and one muon, with at least three or four b
Background The global prevalence of congenital heart disease (CHD) is increasing. Research on patient-reported outcomes (PROs) predominantly originates from high-income countries, resulting in an incomplete understanding of the true global burden of CHD from the patient perspective. Therefore, we described perceived health, psychological distress and quality of life (QoL) in a large sample of adul
