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Background: Hexavalent chromium (Cr(VI)) is a lung cancer carcinogen. However, the genotoxic and mutagenic effects of Cr(VI) in humans at low-to-moderate occupational exposure levels are unknown. This study aims to investigate the relationship between occupational exposure to Cr(VI) and the presence of oxidative damage, genetic and epigenetic alterations. Methods: We included 113 Cr(VI) exposed wo
Context Developing compilers and static analysis tools (“language tools”) is a difficult and time-consuming task. We have previously presented property probes, a technique to help the language tool developer build understanding of their tool. A probe presents a live view into the internals of the compiler, enabling the developer to see all the intermediate steps of a compilation or analysis rather
Many software language tools use declarative domain-specific languages (DDSLs) to implement parts of their functionality, such as context-free grammars for parsing or inference rules for type analysis. For interoperability and ease of use, DDSLs often rely on embedded general-purpose language (GPL) code fragments, as in the semantic actions of parser specifications, but require that these GPL frag
Sundarban mangrove is the largest continuous mangrove forest in the world and is the habitat of an incredible amount of biodiversity. Biodiversity loss and degradation of this highly ecologically productive mangrove forest due to climate change will have a tremendous impact on the livelihood of the people living in the deltaic region. The present study was aimed to find out the dynamics of change
This study investigates new and alternative communication models of sustainable fashion within Instagram thrift stores in India using digital affordances of social media platforms. Drawing from interdisciplinary areas of fashion, media, and sustainability, we explore how social media platforms, such as Instagram, enable sustainable fashion systems of creation and consumption in distinct socio-ecol
Background: Glucose-dependent insulinotropic polypeptide (GIP) was the first incretin identified and plays an essential role in the maintenance of glucose tolerance in healthy humans. Until recently GIP had not been developed as a therapeutic and thus has been overshadowed by the other incretin, glucagon-like peptide 1 (GLP-1), which is the basis for several successful drugs to treat diabetes and
This article explores two works by Swedish artists Emanuel Cederqvist and Henrik Andersson that relate to the vast alpine areas of Norrland in the far north of Sweden. In both works, the artists relate their experiences of the area as it exists today as well as the layers of its history through both archival material and their own photographs. More specifically, both artists use material that show
Organ function depends on the three-dimensional integrity of the extracellular matrix (ECM). The structure resulting from the location and association of ECM components is a central regulator of cell behavior, but a dearth of matrix-specific analysis keeps it unresolved. Here, we deploy a high-resolution, 3D ECM mapping method and design a machine-learning powered pipeline to detect and characteri
The tyrosine residue in amyloid-β (Aβ) is susceptible to attack by various reactive nitrogen intermediates, leading to the formation of 3-nitrotyrosine (3-NT), a post-translational modification associated with the pathophysiology of Alzheimer's disease (AD). Although considered a “dead-end” product, emerging evidence suggests that 3-NT can be reduced to 3-aminotyrosine (3-AT) in vivo. This study a
In 2020, a case report described autologous transplantation of iPSC-derived dopamine (DA) neurons in a Parkinson's disease (PD) patient.1 The team now follows up with the pre-clinical safety and efficacy data of autologous iPSC-derived DA neurons, forming the basis for regulatory approval of a phase 1 clinical trial involving 8 patients.2
In this article I look at two works by Swedish video artist Lina Selander and explore how underlying visual patterns unfold in these works that are connected to certain worldly phenomena. Borrowing from Jacques Derrida, I describe the tendency of being en mal d'archive as an obsession to structure the world into particular recognizable patterns. I argue that Selander's works can be understood as t
During the past decade, scholars have produced a vast amount of research using linked historical individual-level data, shaping and changing our understanding of the past. This linked data revolution has been powered by methodological and computational advances, partly focused on supervised machine-learning methods that rely on training data. The importance of obtaining high-quality training data
BACKGROUND: This systematic review aims to determine the loads of anti-A and anti-B in plasma-containing blood products that can safely be transfused to adults.MATERIALS AND METHODS: A comprehensive literature search was performed in PubMed, including studies dating back to 1940 until January 1 st, 2023. In total 1,869 articles were screened, describing 86 cases of hemolytic transfusion reactions
Radiolabeled targeting agents have emerged as valuable tools for the treatment of disseminated cancer. Monoclonal antibodies (mAbs) are widely employed as carriers for diagnostic and therapeutic radionuclides due to their exceptional specificity and affinity. However, their prolonged circulatory half-life can diminish diagnostic efficacy and increase radiation exposure to non-target tissues in the
Fatal accidents in UK’s manufacturing sector are expected to remain the same or increase in coming years. This paper has tried to combat this issue by adapting and further developing a previously defined Safety Framework for the Paint Sector, to evaluate the safety performance of a metal manufacturing facility. To achieve this, the original Safety Framework was updated to align with the current Br
Background and Aims: Population-based data on prescribed opioid use among adults with Crohn's disease (CD) remain limited. Methods: This nationwide register-based study included individuals ≥ 18 years with incident (2008–2019) or prevalent (2008–2021) CD and up to 10 individually matched reference individuals without inflammatory bowel disease. We categorised opioid dispensations as weak (e.g., tr
While research on the ramifications of automated decision-making (ADM) for welfare organisations is growing rapidly, less attention has been paid to elucidating the role and experiences of clients in the ADM process. This paper draws attention to how the performance of ADM policy in social assistance organisations working from an activation perspective is not merely a passive way of processing cli
Can compulsory military service breach human rights protections against slavery, servitude or forced or compulsory labour contrary to Article 8 of the International Covenant on Civil and Political Rights (‘ICCPR’) (and/or equivalent provisions in regional human rights instruments) and, in doing so, meet the threshold of persecution under the 1951 Convention Relating to the Status of Refugees? The
