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The amyloid precursor protein intracellular domain (AICD), a cleavage product of amyloid precursor protein implicated in Alzheimer disease and amyloid lateral sclerosis, is a functionally important but structurally elusive intrinsically disordered protein. In this study, we investigate the conformational ensemble of a 35-residue AICD segment encompassing the conserved YENPTY motif using molecular

Recension av ”Filosoferna, del 4: Från filosofins födelse till den vetenskapliga revolutionen ca. 500 f.kr–1650”. Fri tanke.

Transport has a large impact on children’s lives from facilitating or limiting their mobility and access to destinations to impacting their health and wellbeing. However, cities have primarily focused on facilitating motor vehicle travel, which is an adult-exclusive mode. Likely, as a result, many children are escorted to places. In this chapter, we summarize literature on children’s travel from a

Elva visioner för Getteröverkets framtid skapade under en tvåveckors workshop med arkitektstudenter från Lunds universitet. Workshopen är en del av forskningsprojektet Transform som syftar till att utforska hur Getteröverket kan utvecklas från reningsverk till resursverk – vilka resurser kan vi ta tillvara, och hur?WorkshopenSyftet med workshopen var att identifiera på vilket sätt och för vem mark

This article presents a scoping and conceptual literature review on environmental politics in North and East Syria/Rojava. The review aims to synthesize existing academic research in English on the interplay between armed conflict and environmental change in the region, focusing on the Kurdish-led socio-political model known as the Autonomous Administration of North and East Syria (AANES). The stu

Background. Post-traumatic chondral and osteochondral lesions can be treated with autologous chondrocyte implantation (ACI), but the high cost of autologous cell expansion under strict Good Manufacturing Practice (GMP) regulations limits patient access. Stem cell–based advanced therapy medicinal products (ATMPs) offer more cost-effective alternatives, with human induced pluripotent stem cells (iPS

The research evaluated retrofitting options for a threestory church community building in Grevie, Sweden, assessing the impacts on energy efficiency, life cycle cost, and environmental concerns. An energy model was generated in IDA ICE to simulate the building performance. Various improvements were tested in two separate retrofit package scenarios. They had the following measures in common: the ad

Knee osteoarthritis (OA) and obesity are closely linked, with obesity being the primary risk factor for OA. This study used the medial meniscus of sows (250 kg, 4–6 years old) as a model for spontaneous OA, comparing them to lighter pigs (110 kg, 7–8 months old). The joints were collected according to the 3Rs principles (Replacement, Reduction and Refinement) and compared using macroscopic and mic

This study investigates the influence of osteoarthritis (OA) disease severity on the bio-composition of the osteochondral junction at the human tibial plateau using Raman microspectroscopy. We specifically aim to analyze the spatial composition of mineralized osteochondral tissues, i.e., calcified cartilage (CC) and subchondral bone plate (SBP) from unfixed, hydrated specimens. We hypothesize that

Dental caries is the most common oral disease that causes demineralization of the enamel and later of the dentin. Depth-wise assessment of the demineralization process could be used to help in treatment planning. In this study, we aimed to provide baseline information for the development of a Raman probe by characterizing the mineral composition of the dental tissues from large composition maps (6

The influence of joint degeneration on the biomechanical properties of calcified cartilage and subchondral bone plate at the osteochondral junction is relatively unknown. Common experimental difficulties include accessibility to and visualization of the osteochondral junction, application of mechanical testing at the appropriate length scale, and availability of tissue that provides a consistent r

Bridge monitoring is essential for ensuring their long-term safety, reducing disruptions, and supporting economic and social activities. Traditional monitoring techniques rely on periodic inspections and contact-based sensing systems, which, while effective, have limitations due especially to high installation and maintenance costs. Satellite-based Synthetic Aperture Radar Interferometry (InSAR) o

The Swedish province of Västergötland is home to around 180 churches from the Middle Ages and played an important role in the processes of Christianisation and subsequent state-building of Sweden. The roof structures of these churches act as a window to our past where we can learn information on construction dates and techniques as well as the use of local resources, such as timber. In this joint

This study presents the fabrication of all-dielectric silicon-based twisted L-shape metamaterials using a two-step electron-beam glancing angle deposition approach. Systematic chiroptical characterization and optimization are performed through Mueller matrix generalized spectroscopic ellipsometry and finite element modeling, demonstrating tunable, broadband chirality response with potential applic

We report the fabrication of three-dimensional topological insulator heterostructures using a single-step bottom-up approach based on directional solidification. These materials exhibit atomically smooth interfaces, preserving topological surface states and enabling hetero-junction formation. This scalable approach paves the way for advancements in spintronics, quantum computing, and novel optoele

Meta-analyses are vital for synthesizing evidence in medical research, but conflicts of interest can introduce research bias, undermining the reliability of the synthesized findings. This paper proposes a new robust Bayesian meta-analysis model. The model inflates uncertainty of low-quality studies and incorporates a bias term for studies subject to conflicts of interest. Using a random-effects mo

Enzymes serve as biological catalysts in a wide range of applications, from household products to industrial processes, research, diagnostics and forensic science. They accelerate reactions with high specificity under mild reaction conditions and are essential for life. Advances in recombinant DNA technology have enabled the use of microorganisms as efficient cell factories for production of heter

Understanding 3D human interactions is fundamental for fine-grained scene analysis and behavioural modeling. However, most of the existing models predict incorrect, lifeless 3D estimates, that miss the subtle human contact aspects–the essence of the event–and are of little use for detailed behavioral understanding. This paper addresses such issues with several contributions: (1) we introduce model