Filtyp
People keep starting businesses despite the high probability of failure. This paradox is often blamed on overconfidence, but existing research tends to confound different dimensions of overconfidence into a single, blurry bias. This thesis separates overconfidence into its three distinct dimensions: overestimation, overplacement, and overprecision. The goal is to see if having prior entrepreneuria
Sustainable startups are recognized as both risky yet important drivers of innovation to societal and environmental challenges, whereas Venture capital (VC) firms play a critical role in enabling growth through financing and active ownership. Although sustainability is becoming a requirement and a driving force for the future, prior literature points to fragmented frameworks and weak risk assessme
This study examines how early-stage entrepreneurs come to engage in financial bootstrapping under conditions of financial constraint. Existing research has largely focused on the techniques entrepreneurs use to bootstrap and the structural conditions associated with such behaviour, while the interpretive process through which bootstrapping becomes a workable response has received limited attention
Smoldering multiple myeloma (SMM) is a precursor to multiple myeloma (MM) and present in 0.5% of the population over 40 years old [1, 2]. In 10–20% of MM patients, the clonal BMPC do not produce intact M proteins but only free light chains (FLC) [3, 4]. This subgroup termed light-chain MM and well-characterized, but light-chain SMM is not clearly defined.Historically, monoclonal FLC were detected
This chapter reviews and critically examines the evolution of systemic conceptual perspectives on energy innovation. It argues that energy innovation is by definition a systemic innovation problem, which cannot be adequately depicted with linear or chain-linked innovation models. It rather depends on complex and interrelated changes in technologies, actor networks and institutional arrangements, w
Importance Biological staging of Alzheimer disease (AD) can improve diagnostic accuracy and prognostic assessment. However, existing approaches often require invasive procedures and specialized infrastructure, limiting their routine clinical use. Objective To develop and validate a plasma-based biological staging model that closely mirrors an amyloid and tau positron emission tomography (PET)–base
Background: According to the World Health Organization, all healthy pregnant women are recommended to engage in at least 150 min of regular moderate-intensity aerobic activity per week. This level of physical activity is associated with numerous physical and psychological health benefits and helps to reduce the risk of being overweight, gestational diabetes, and preeclampsia. Despite its importanc
Trust is widely recognised as an important determinant of lending relationships, yet existing finance literature typically treats trust as a single construct and rarely examines how different trust dimensions operate across financial contracts with distinct risk structures. Our research addresses this gap by distinguishing between competence-based trust (perceived managerial capability) and value-
Amyloid deposition is a hallmark of numerous age-related diseases, and understanding the chemical mechanisms that govern amyloid formation is crucial for advancing the rational development of protein aggregation inhibitors. With amyloid formation rates varying widely across proteins, here we report the quantitative aggregation mechanism of medin, the most common localized amyloid in humans, and fi
Time-dependent diffusion MRI enables the estimation of water exchange rates in vivo. Most studies attribute these estimates to membrane permeability. However, non-permeative geometric exchange may also contribute. The present study investigates the contribution of geometric exchange between dendritic spines and shafts to diffusion MRI-derived exchange estimates. Monte Carlo simulations were perfor
Inclination-dependent grain boundary (GB) energy and shear-coupled motion are studied for [001] and [111] tilt GBs in face-centered cubic materials using three-dimensional (3D) phase field crystal (PFC) simulations. A large dataset spanning misorientation and inclination space is systematically generated to evaluate trends in GB energy and shear-coupling. GB energy variations broadly follow ideal
Objectives: FLASH radiotherapy is an innovative technique that delivers radiation at ultra-high dose rates (UHDR), offering tumor control comparable to conventional (CONV) radiotherapy while significantly reducing normal tissue toxicity. Here we aim to determine the effects of FLASH compared to CONV radiotherapy in muscle-invasive bladder cancer (MIBC) models. Methods: Using an in-house 6 MeV line
Aims: To describe healthcare professionals’ interactions with pediatric patients at an adult ICU. Methods: This non-participant naturalistic observational study was conducted at two adult ICUs in Sweden. Inclusion criteria were children aged 0–15 years, where both the child and the parent could speak and understand Swedish or English. Children undergoing palliative care were excluded. The observat
This study presents a multidisciplinary analysis of 119 osseous and ivory fragments from the necropolis of La Beleña (Córdoba, Spain) dating between the second half of the 4th and the beginnings of the 3rd Millennium BC, aiming to assess the effectiveness and limitations of current methods used for identifying ivory provenance in prehistoric contexts. Traditional macroscopic and microscopic techni
BACKGROUND: Obesity is a major risk factor for heart failure (HF). However, individuals with similar body mass index (BMI), the main diagnostic measure of obesity, exhibit considerable heterogeneity in developing HF.OBJECTIVES: This study aimed to investigate the association between metabolically discordant subgroups characterized by cardiometabolic biomarkers deviated from those predicted by BMI
BACKGROUND: The EAT-Lancet Commission introduced the planetary health diet to promote human health while reducing environmental impact. However, no study has yet examined how adherence to this diet is associated with risk of irritable bowel syndrome (IBS).OBJECTIVE: This study aimed to investigate the association between the planetary health diet index (PHDI) and the risk of developing IBS.METHODS
Seasonality can drive the evolution of reproductive plasticity in insects. An extreme form is reproductive diapause, where individuals halt reproduction during unfavourable seasons. How diapause evolves from milder forms of plasticity (e.g., through changes in cue perception and responses) is poorly understood. In the tropics, seasonality is common, but it is unclear how widespread reproductive pl
