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We report the inverse association between the expression of androgen receptor (AR) and interleukin-1beta (IL-1β) in a cohort of patients with metastatic castration resistant prostate cancer (mCRPC). We also discovered that AR represses the IL-1β gene by binding an androgen response element (ARE) half-site located within the promoter, which explains the IL-1β expression in AR-negative (ARNEG) cance
How do new companies attempt to captivate customers in a food market they are substantially seeking to transform? Plant-based meat has been marketed as a revolutionary food product that will not only transform markets but also provide better health and reduced environmental harms. Building on conceptualizations of captivation, we analyze video ads from leading brands. Our results highlight four mo
DNA mutations in specific genes can confer preferential benefit from drugs targeting those genes. However, other molecular perturbations can "phenocopy" pathogenic mutations, but would not be identified using standard clinical sequencing, leading to missed opportunities for other patients to benefit from targeted treatments. We hypothesized that RNA phenocopy signatures of key cancer driver gene m
To meet future demands for cleaner water and comply with the revised Urban Wastewater Treatment Directive (UWWTD), many European wastewater treatment plants (WWTPs) will need quaternary treatment to reduce emissions of organic micropollutants (OMPs). Quaternary treatment based on granular activated carbon (GAC) is a promising solution, yet long-term, full-scale operational data remain scarce. This
Purpose To investigate patient-reported symptom relief day-by-day and the use of postoperative analgesics after open trigger finger release. The primary outcome of this study was the number of days to resolution of pain. Secondary outcomes were the use of analgesics and the number of days to complete resolution of stiffness and triggering. Methods In this prospective, multicenter cohort study, a t
We develop a Lyapunov-based analysis of Korpelevich’s extragradient method and show that it achieves an o(1/k) last-iterate convergence rate of the constructed Lyapunov function. This Lyapunov function simultaneously upper bounds several standard measures of optimality, which allows our analysis to sharpen existing last-iterate convergence guarantees for these measures. Moreover, the same analysis
Introduction: The importance of measuring vascular age has been emphasized in numerous studies, highlighting its critical role in precision medicine. This cross-sectional heterogeneity exploration study examined sex- and country-specific association of serum uric acid (SUA) and inflammation, measured as high sensitivity C-reactive protein (hs-CRP), and vascular aging across populations with divers
Background Aortic valve calcification (AVC) is a disease process driven by inflammation and lipid infiltration, serving as a precursor to aortic stenosis. While male sex has been implicated as a risk factor for AVC, sex-specific differences, particularly among younger individuals in the general population, are not well characterised. Methods The Swedish CArdioPulmonary BioImage Study was used, com
The downscaling of environmental responsibilities poses new challenges for regional governments, necessitating an evolution in their roles to manage environmental policy alongside traditional local development duties. This paper draws on the concept of the entrepreneurial state and on the idea of the ‘entrepreneurial region’ to explore how local and regional governments implement bioeconomy polici
Abstract: Perfusion MRI techniques—including dynamic susceptibility contrast (DSC) MRI, dynamic contrast-enhanced (DCE) MRI, arterial spin labeling (ASL) MRI, and intravoxel incoherent motion (IVIM) MRI—hold strong potential as imaging techniques for diagnosing, staging, and monitoring disease across a range of clinical applications. However, clinical adoption, especially of quantitative parameter
Purpose: Surgical repair of parastomal hernias (PH) is challenging, mainly due to high recurrence rates. The Local Parastomal repair (LoPa) is a novel technique utilizing a retromuscular synthetic mesh with an outward-facing collar. This study describes the LoPa technique and evaluates its outcomes. Methods: This single-centre study retrospectively reviewed 39 consecutive patients who underwent Lo
Aim: To provide an overview of a project aimed at enhancing person-centred surgical care through teamwork and professional development. Design: A discursive paper with the purpose of describing and discussing the project activities to strengthen person-centred care, teamwork and professional development. Methods: This project aimed to strengthen evidence-based surgical nursing care within a Surger
Treatment response in pediatric social anxiety disorder (SAD) is highly variable, and symptoms may be maintained by maladaptive attention. A previous study found that youth with SAD scan a more restricted area of faces than healthy controls during emotion recognition, potentially limiting interpretation of social cues. The current study followed up on these results by examining whether restricted
Wages earned by men are often used as an indicator of the material standard of living (MSoL). However, this indicator relies on several assumptions when used for comparisons across time and space. Considering these assumptions will improve estimates of the MSoL from wages. One necessary assumption is that households in the compared populations relied on the primary income of the male head of house
