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Development of drug resistance is a mounting problem in precision oncology, demanding a rethink of treatment strategy. We here apply concepts from military theory and espionage to the battle-like dynamics between cancer and its host, thereby identifying system vulnerabilities in cancer and ways of tricking cancer’s evolution into dead ends.
Eyeblink conditioning is used in many species to study motor learning and make inferences about cerebellar function. However, the discrepancies in performance between humans and other species combined with evidence that volition and awareness can modulate learning suggest that eyeblink conditioning is not merely a passive form of learning that relies on only the cerebellum. Here we explored two wa
Erosion and infrastructure in the Arctic can change the thickness of the active layer which can subsequently alternate the thermal-hydrological regime and change the drainage patterns on slopes. Previous studies have shown that drainage can either decrease due to the movement of water occurring in deeper soil layers with lower permeability or increase due to the formation of features like gullies
Prostate-specific antigen (PSA) screening for prostate cancer remains controversial because it increases overdiagnosis and overtreatment of clinically insignificant tumors. Accounting for genetic determinants of constitutive, non-cancer-related PSA variation has potential to improve screening utility. In this study, we discovered 128 genome-wide significant associations (P < 5 × 10 -8) in a multi
A 61-year-old male patient presented with rest pain and ulceration in his left leg 1 week after a hybrid procedure with bilateral external iliac stenting, common femoral artery thromboendarterectomy, and left-sided femoral popliteal bypass with an in situ saphenous vein. The bypass had been stented intraoperatively but had again become occluded directly after surgery. In the present report, we dem
We report the case of a 63-year-old man who presented with a 2-week complaint of lower extremity pain, swelling, and low-grade fever after an episode of septic arthritis in the ipsilateral knee. The investigation showed a rapidly expanding popliteal artery aneurysm (PAA). The rare clinical entity of an infective PAA was suspected and was confirmed by the cultures obtained at the right femoropoplit
Manual gestures and speech form a single integrated system during nativelanguage comprehension. However, it remains unclear whether this hold forsecond language (L2) comprehension, more specifically for simultaneousinterpreting (SI), which involves comprehension in one language and simultaneousproduction in another. In a combined mismatch and priming paradigm,we presented Swedish speakers fluent i
IMPORTANCE: The clinical utility of stress cardiovascular magnetic resonance imaging (CMR) in stable chest pain is still debated, and the low-risk period for adverse cardiovascular (CV) events after a negative test result is unknown.OBJECTIVE: To provide contemporary quantitative data synthesis of the diagnostic accuracy and prognostic value of stress CMR in stable chest pain.DATA SOURCES: PubMed
Child stunting prevalence is primarily used as an indicator of impeded physical growth due to undernutrition and infections, which also increases the risk of mortality, morbidity and cognitive problems, particularly when occurring during the 1000 days from conception to age 2 years. This paper estimated the relationship between stunting prevalence and age for children 0-59 months old in 94 low- an
The post-racial discourse that permeates many Western European countries depicts society as having moved beyond race concepts and classifications. This article focuses on Sweden, a country that, in line with the post-racial thinking, declares race to be an offensive and unscientific concept. The article investigates what happens when this post-racial discourse meets clinical research standards tha
Abstract in ItalianPubblicazione realizzata da IL CLUB degli autori in quanto Opera 2^ Classificata al Premio di Poesia «Ebook in… versi 2022»Questa la motivazione della Giuria: «Le ventitré liriche della silloge di Carla Killander Cariboni colgono e fissano frammenti delle molteplici manifestazioni della vita e diventano paradigma dell’esperienza esistenziale e della finitudine dell’Uomo.Le stagi
PURPOSE: The intracorporeal anastomosis (IA) technique possibly results in enhanced recovery and reduced morbidity rates compared to the extracorporeal anastomosis (EA) technique. This study compared the short-term morbidity rates of IA versus EA in segmental resections for colon cancer.METHOD: We performed a retrospective cohort study of consecutive patients from 2015 to 2020 using the IA or EA t
PURPOSE: Water saturation shift referencing (WASSR) Z-spectra are used commonly for field referencing in chemical exchange saturation transfer (CEST) MRI. However, their analysis using least-squares (LS) Lorentzian fitting is time-consuming and prone to errors because of the unavoidable noise in vivo. A deep learning-based single Lorentzian Fitting Network (sLoFNet) is proposed to overcome these s
Personer med självskadebeteende och komplex psykisk ohälsa kan förväntas vara suicidnära. De kommer att vara suicidnära under hela den Brukarstyrda inläggningen (BI). På tre dagar kan vi inte ändra på det. Det kan ta år tills stress inte längre triggar suicidalitet. Det vi kan hjälpa till med under BI är stressen.Denna manual (med tillhörande utbildning som tillhandahålls som uppdragsutbildning fö
