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Non-responders to checkpoint inhibitors generally have low tumor T cell infiltration and could benefit from immunotherapy that activates dendritic cells, with priming of tumor-reactive T cells as a result. Such therapies may be augmented by providing tumor antigen in the form of cancer vaccines. Our aim was to study the effects of mitazalimab (ADC-1013; JNJ-64457107), a human anti-CD40 agonist IgG
Did the different public-health policies that Sweden and Denmark pursued in the beginning of the COVID-19 pandemic result in different levels of public trust in governments’ and health authorities’ ability to guide the two countries safely through the pandemic? How did the level of trust change as the pandemic unfolded? And were there any cross-country differences in the correlates of trust? Using
We study questions of existence and uniqueness of quadrature domains using computational tools from real algebraic geometry. These problems are transformed into questions about the number of solutions to an associated real semi-algebraic system, which is analyzed using the method of real comprehensive triangular decomposition.
Den andra av två artiklar rörande det fängelse, den s k proban, som Lunds universitet hade under den tid lärosätet ägde egen jurisdiktion över anställda och studenter. Denna andra del behandlar studentoroligheter under tidigt 1800-tal, den oklara frågan var proban var placerad under 1800-talet samt några av de sista studenterna att spärras in häri under 1830- och 1840-talen, dels för brott, dels s
The argument and discussion in this paper begins from the premise that Hume was an atheist who denied the religious or theist hypothesis. However, even if it is agreed that that Hume was an atheist this does not tell us where he stood on the question concerning the value of religion. Some atheists, such as Spinoza, have argued that society needs to maintain and preserve a form of “true religion”,
Background: The positive effects of Kangaroo mother care in NICU’s are well documented but, to a lesser extent, explored during inter-hospital neonatal transport. Inter-hospital transport, with the infant placed in a transport incubator, increases the risk of separation while infants in Kangaroo mother care position implies that the parents accompany the transport. There exists limited knowledge i
Vertical III-V nanowire MOSFETs show potential towards the ultimate transistor scaling. A high transconductance and current density are achieved based on the gate-all-around architecture. This work presents a high-frequency design of such devices, achieving more than 600 GHz cut-off frequencies (fT, fmax), at 20 nm gate length. Furthermore, capacitance design and scaling trends, supported by COMSO
Historik över tidningen Lundagård med anledning av dess 100-årsjubileum.
Public sector services are audited, measured and ranked in order to improve quality and transparency and to prompt organizations to conform to normative definitions of quality. In Swedish eldercare, a nationwide user survey distributed by the public authorities to all eldercare users, designed to gauge user satisfaction, is a prominent example of this form of soft governance. The aim of the presen
The propagation of premixed reacting waves can be characterized by a displacement speed Sd at which the local surface of the reaction progress scalar moves respective to flow. Often, Sd is considered through decomposition into three parts of contribution due to the tangential diffusion of curvature, normal diffusion, and reaction. A set of recently derived transport equations for Sd and three of i
The study of a turbulent premixed flame often involves analysing quantities conditioned to different iso-surfaces of a reactive scalar field. Under the influence of turbulence, such a surface is deformed and translated. To track the surface motion, the displacement speed of the scalar field respective to the local flow velocity is widely used and this quantity is currently receiving growing attent
Motivated by the influence of (micro-)cracks on the effective electrical properties of material systems and components, this contribution deals with fundamental developments on electro-mechanically coupled cohesive zone formulations for electrical conductors. For the quasi-stationary problems considered, Maxwell’s equations of electromagnetism reduce to the continuity equation for the electric cur
Effective weed control in agricultural crop fields increases yields, but simultaneously reduces floral resources for pollinators because many weed species provide pollen and nectar. Consequently, efforts to enhance crop yields on organic farms by using effective weed control methods risk compromising positive effects of organic farming on pollinating insects. Thus, it is important to find manageme
While successes in the prevention of mother-to-child transmission program are believed to lead to substantial reductions in new perinatal infections, new sexually acquired infections among the older adolescent group seem to fuel the HIV epidemic. That is why adolescents are the only age group in which an increase in new HIV infections was reported in the latest global HIV progress update. Increase
Background: Previous studies suggested that automated peritoneal dialysis (APD) could be improved in terms of shorter treatment times and lower glucose absorption using bimodal treatment regimens, having ‘ultrafiltration (UF) cycles’ using a high glucose concentration and ‘clearance cycles’ using low or no glucose. The purpose of this study is to explore such regimes further using mathematical opt
Introduction: Patients with midgut neuroendocrine tumours (NETs) suffer from decreased health-related quality of life (HRQoL), in large part due to bowel symptoms. However, it is unknown which bowel symptoms affect HRQoL the most. An enhanced understanding of this is essential to better focus treatment on this aspect of the disease. This study aimed to determine which bowel symptoms affect HRQoL t
Background: MRI is used to evaluate structural joint changes after anterior cruciate ligament (ACL) injury, but no long-term data are available for comparing different treatment approaches. Purpose: To describe structural joint damage with MRI over a 5-year period in the Knee Anterior Cruciate Ligament, Nonsurgical versus Surgical Treatment (KANON) study and to compare frequencies of such tissue d
Background: Little is known about the heterogeneous etiology of suspected non-Alzheimer’s pathophysiology (SNAP), a group of subjects with neurodegeneration in the absence of β-amyloid. Using antemortem MRI and pathological data, we investigated the etiology of SNAP and the association of neurodegenerative pathologies with structural medial temporal lobe (MTL) measures in β-amyloid-negative subjec
