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Angiotensin II (Ang II) induces marked, dynamic increases in the permeability of the glomerular filtration barrier (GFB) in rats. After binding to its receptor, Ang II elicits Ca2+ influx into cells, mediated by TRPC5 and TRPC6 (transient receptor potential canonical type 5 and 6). Clemizole and La3+ salts have been shown to block TRPC channels in vitro, and we therefore tested their potential eff
Base-catalyzed depolymerization of black liquor retentate (BLR) from the kraft pulping process, followed by ultrafiltration, has been suggested as a means of obtaining low-molecular-weight (LMW) compounds. The chemical complexity of BLR, which consists of a mixture of softwood and hardwood lignin that has undergone several kinds of treatment, leads to a complex mixture of LMW compounds, making the
The urbanisation of cities increases the demands on, and complexity of, urban land use. Urban densification is challenging urban green space. Cities have responded to this challenge by adopting a multiple-use strategy where different functions share space. Shrinking open space has to contain solutions for everyday functions such as bicycle parking, waste sorting, blue-green stormwater systems, and
Background: Integrating and scaling up tuberculosis (TB) and HIV services are essential strategies to achieve the combined goals ending both TB and HIV, especially in TB and HIV high burden countries. This study aimed to examine the prevalence of TB and HIV co-infection and the implementation of collaborative services in Ethiopia.Methods: We used a national sentinel surveillance TB/HIV co-infectio
Hovering insects are divided into two categories: ‘normal’ hoverers that move the wing symmetrically in a horizontal stroke plane, and those with an inclined stroke plane. Normal hoverers have been suggested to support their weight during both downstroke and upstroke, shedding vortex rings each half-stroke. Insects with an inclined stroke plane should, according to theory, produce flight forces on
Wood is a renewable resource and a promising construction material for the growing bio-based economy. Efficiently utilising wood in the built environment requires a comprehensive understanding of the dynamics regarding its usability. Durability is an essential property to consider, as various types of exposure create conditions for the deterioration of wood through biotic and abiotic agents. Biode
Droplet microfluidics is a powerful method used to characterize chemical reactions at high throughput. Often detection is performed via in-line optical readout, which puts high demands on the detection system or makes detection of low concentration substrates challenging. Here, we have developed a droplet acoustofluidic chip for time-controlled reactions that can be combined with off-line optical
Understanding of the mechanics of the brittle-ductile transition (BDT) in porous limestone is significantly more challenging than for sandstone because of the lack of consistent acoustic emission activity in limestone, meaning that one must rely on alternative techniques. In this paper, we investigate systematically the failure modes in Indiana limestone using X-ray microComputed Tomography imagin
High levels of microvesicles (MVs), a type of extracellular vesicles, are detected in several pathological conditions. We investigated the connection between coronary flow reserve (CFR), a prognostic clinical parameter that reflects blood flow in the heart, with levels of MVs and their cargo, from plasma of patients with cardiovascular disease. The PROFLOW study consists of 220 patients with prior
Oceanic deoxygenation is increasingly affecting marine ecosystems; many taxa will be severely challenged, yet certain nominally aerobic foraminifera (rhizarian protists) thrive in oxygen-depleted to anoxic, sometimes sulfidic, sediments uninhabitable to most eukaryotes. Gene expression analyses of foraminifera common to severely hypoxic or anoxic sediments identified metabolic strategies used by t
Petrostates face an unprecedented crisis as oil and gas revenues, on which their economies and states are built upon, are set to diminish rapidly the coming 20 years. The decline in revenues is an effect of the adopted climate policies in the major oil consuming countries that, together with a strong development of renewable energy, reduces the future demand for oil and gas. The challenges that thPetrostates face an unprecedented crisis as oil and gas revenues, on which their economies and states are built upon, are set to diminish rapidly the coming 20 years. The decline in revenues is an effect of the adopted climate policies in the major oil consuming countries that, together with a strong development of renewable energy, reduces the future demand for oil and gas. The challenges that th
The prevailing demographic change in the western world means that theworkforce is becoming older. Farmers in particular often work beyond the normalretirement age, in a challenging physical environment. For example, the agriculturalsector has the most hazardous work environment in Sweden. Therefore, it is interestingto examine the following questions: Are senior farmers more frequently involvedin
Background Mercaptobenzothiazole compounds are associated with allergic contact dermatitis caused by rubber products. Several screening substances have been used for patch testing. Objective To compare the frequency of positive test reactions to a mercapto mix containing a higher concentration of 2-mercaptobenzothiazole with reactions to the combination of 2-mercaptobenzothiazole 2.0% and mercapto
På grund av den förändrade demografin blir det allt fler äldre inom arbetskraften i västvälden. Detta inte minst inom lantbruket där antalet äldre som arbetar kvar till en hög ålder är betydande. De generella fysiologiska förändringarna med ökande ålder, som exempelvis sämre syn, hörsel och reaktionsförmåga, är riskfaktorer för att drabbas av arbetsskador. Lantbruket är samtidigt en av Sveriges fa
The aim of this knowledge compilation is to contribute with know-ledge about the work environment in relation to the ever-older workforce. How do employee needs and possibilities change from a course of life perspective? What should the employer and other work environment actors think about in order for the workforce to be able to and want to work to a high age? The Swedish Work Environment Author
Since its modern conception, police research has shown an interest in everyday life. This has to do with how this (sub)discipline, more than other areas of criminological thought, has been founded on ethnographic methods. Since Westley’s study in the 1950s, scholars have agreed on the importance of not simply studying policing through proxies, but also observing and studying the workaday reality o
It has become theoretical orthodoxy to point to and problematise a rise in surveillance. This article contributes to this debate. Following a still marginal yet budding number of studies that focus on the practical, quotidian level of surveillance systems, the article ethnographically examines the daily surveillance work of a number of Danish detectives. What is demonstrated is that whilst the Dan
