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PURPOSE: Ductal carcinoma in situ (DCIS) patients and their physicians currently face challenging treatment decisions with limited information about the individual's subsequent breast cancer risk or treatment benefit. The DCISionRT biological signature developed in this study provides recurrence risk and predicts radiotherapy (RT) benefit for DCIS patients following breast-conserving surgery (BCS)
Background: Venous thromboembolism (VTE) (pulmonary embolism [PE] or deep venous thrombosis [DVT]) is common during acute COVID-19. Long-term excess risk has not yet been established. Objectives: To study long-term VTE risk after COVID-19. Methods: Swedish citizens aged 18 to 84 years hospitalized and/or testing positive for COVID-19 between January 1, 2020, and September 11, 2021 (exposed), strat
The COVID-19 pandemic has accelerated the digital transformation of Higher Education, necessitating a rapid shift from in-person to remote teaching and learning. This study investigates the experiences of doctoral students in an online Sino-Nordic summer school on aging, implemented during the pandemic. A survey was conducted to collect and analyze data on participants’ experiences and perspective
Alzheimer's disease is a neurodegenerative condition which involves heavy neuronal cell death linked to oligomers formed during the aggregation process of the amyloid β peptide 42 (Aβ42). The aggregation of Aβ42 involves both primary and secondary nucleation. Secondary nucleation dominates the generation of oligomers and involves the formation of new aggregates from monomers on catalytic fibril su
En ökad kunskap och medvetenhet i vården och i samhället om palliativa vårdbehov skulle ge våra medborgare en bättre och tryggare tillvaro i livets slutskede.I den vård som bedrivs när livet närmar sig sitt slut saknas ofta – planering för vården i livets slutskede trots multisjuklighet och hög ålder– brytpunktssamtal eller informerande samtal med närstående – dokumentation av patienters behov, ön
Context. Cool stars, such as M giants, can only be analyzed in the near-infrared (NIR) regime due to the ubiquitous titanium oxide features in optical spectra of stars with Teff<4000 K. In dust-obscured regions, the inner bulge and Galactic center region, the intrinsically bright M giants observed in the NIR are an optimal option for studying stellar abundances and the chemical evolution of stella
Main recommendations: Endoscopic mucosal resection (EMR) is the standard of care for the complete removal of large (≥ 10mm) nonpedunculated colorectal polyps (LNPCPs). Increased detection of LNPCPs owing to screening colonoscopy, plus high observed rates of incomplete resection and need for surgery call for a standardized approach to training in EMR. 1 Trainees in EMR should have achieved basic co
Introduction: Head-to-head evaluation of valoctocogene roxaparvovec, the first gene therapy approved for haemophilia A, with emicizumab is not available. Therefore, phase 3 trial data were indirectly compared. Aim: To compare bleeding rates in trials evaluating 6 × 1013 vg/kg valoctocogene roxaparvovec (GENEr8-1; NCT03370913), 1.5 mg/kg emicizumab dosed every week (HAVEN 3; NCT02847637), and FVIII
We describe glaci-lacustrine sediments buried under thick tills in Folldalen, south-east Norway, a site located close to the former centre of the Scandinavian Ice Sheet. Thus, the location implies that the ice sheet had melted when the sediments were deposited. The exposed ground was occupied by arctic vegetation. The best age estimate from 20 quartz luminescence dates is 55.6 ± 4.6 ka. Due to pos
Företag marknadsför över 200 mjukvaror för artificiell intelligens (AI) inom radiologi.Vårdgivare behöver ha möjlighet till opartisk och kvalitetssäkrad utvärdering.Projektet Validering av AI inom bröstradiologi (VAI-B) startades för att möta detta behov, initialt inom mammografiscreening.
Smart contracts are programs with data (mutable state); stored on and executed by blockchain platforms. The transactions (or function invocations) dispatched to smart contracts often change their state. In the Ethereum blockchain, nodes (aka miners/validators) can schedule a set of transactions in any order in a block. Multiple transactions in a single block operating on a contract's shared state
The present communication describes the use of an emissions barrier to prevent spread of hydrolysis products from plastizisers in plastic mats and from the glue used to attach such mats onto a concrete slab. In particular, 2-ethylhexanol was focussed at. Elevated air concentrations of 2-ethylhexanol has been associated with a range of health symptoms such as e.g. cough, airways irritation, fatique
Objectives To assess the effects of interventions authorised by the European Medicines Agency (EMA) or the US Food and Drug Administration (FDA) for prevention of COVID-19 progression to severe disease in outpatients. Setting Outpatient treatment. Participants Participants with a diagnosis of COVID-19 and the associated SARS-CoV-2 virus irrespective of age, sex and comorbidities. Interventions Dru
We present an updated version of the QCD-based colour reconnection model in Pythia8, where we constrain the range in impact parameter for which reconnections are allowed. In this way, we can introduce more realistic colour reconnections in the Angantyr model for heavy ion collisions, where previously only reconnections within separate nucleon sub-collisions have been allowed. We investigate how th
Hanteringen av stallgödsel i jordbruket orsakar en stor del av utsläppen av ammoniak i Sverige. För att uppnå Sveriges mål om att minska utsläppen av ammoniak behöver jordbrukare utföra åtgärder som minskar utsläppen av ammoniak. Samtidigt är det viktigt att ta hänsyn till hur åtgärder som minskar ammoniakutsläppen också kan bidra till att minska utsläpp av växthusgaserna metan och lustgas. Här di
Introduction: Female surgeons remain a minority within the field of orthopaedics, particularly in certain specialties such as arthroplasty. There is no scientific evidence on whether the surgeon's sex affects the patient-reported outcome after orthopaedic surgery such as total hip arthroplasty (THA). We therefore aimed to investigate the association between surgeon sex and health-related quality o
[Context] Accurate time estimation is a critical aspect of predictable software engineering. Previous work shows that low source code quality increases the uncertainty in issue resolution times. [Objective] Our goal is to evaluate how developers' project experience and file ownership are related to issue resolution times. [Method] We mine 40 proprietary software repositories and conduct an observa
In recent years, the need for sustainable practices within the food industry has become increasingly important and incorporating Industry 4 [...]
Cosmological models and their parameters are widely debated, especially about whether the current discrepancy between the values of the Hubble constant, H 0, obtained by Type Ia supernovae (SNe Ia) and the Planck data from the cosmic microwave background radiation could be alleviated when alternative cosmological models are considered. Thus, combining high-redshift probes, such as gamma-ray bursts
High-performance broadband photodetectors offering spectral tunability and a high gain-bandwidth product are crucial in many applications. Here, we report on a detailed experimental and theoretical study of three-terminal phototransistors comprised of three million InP nanowires with 20 embedded InAsP quantum discs in each nanowire. A global, transparent ITO gate all around the nanowires facilitat
