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Background: Despite many atrial fibrillation (AF) patients being at risk of bleeding, very limited data are available on bleeding rates of different direct oral anticoagulants based on the spectrum of bleeding risk. Objective: We aimed to compare the risk of major bleeding and thromboembolic events with apixaban vs rivaroxaban for AF patients stratified by bleeding risk. Methods: We conducted a po

Objective To estimate the prevalence of the curable sexually transmitted infections (STIs) Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis and Treponema pallidum, to identify associated risk factors and to assess ciprofloxacin resistance in N. gonorrhoeae-positive specimens among female sex workers (FSWs) in Guinea-Bissau. Methods For this cross-sectional

In this article, we present our edited volume, "New Directions in Digitalisation: Perspectives from EU Competition Law and the Charter of Fundamental Rights." We examine the EU's recent regulatory initiatives, particularly the Digital Markets Act (DMA), and their implications for competition law and fundamental rights. The article provides an analysis of how the DMA aims to address market imbalanc

Genotypes causing pregnancy loss and perinatal mortality are depleted among living individuals and are therefore difficult to find. To explore genetic causes of recessive lethality, we searched for sequence variants with deficit of homozygosity among 1.52 million individuals from six European populations. In this study, we identified 25 genes harboring protein-altering sequence variants with a str

The 2022 PSOGI (Peritoneal Surface Oncology Group International) and RENAPE (French Network for Rare Peritoneal Malignancies) consensus on hyperthermic intraperitoneal chemotherapy (HIPEC) was a comprehensive effort aimed at standardizing treatment protocols for various peritoneal malignancies. This initiative is critical due to the wide range of technical variations in HIPEC procedures and the re

The 10E8 antibody targets a helical epitope in the membrane-proximal external region (MPER) and transmembrane domain (TMD) of the envelope glycoprotein (Env) subunit gp41 and is among the broadest known neutralizing antibodies against HIV-1. Accordingly, this antibody and its mechanism of action valuably inform the design of effective vaccines and immunotherapies. 10E8 exhibits unusual adaptations

Amyloid protein deposits are the hallmark of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, or diabetes type II. Although their connection to the diseases is not fully understood, many studies point at intermediate species called oligomers as being the main responsible for the toxicity of these proteins. This makes them strong candidates as therapeutic targets. However, due to their

BACKGROUND: There is a well-known comorbidity between chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) which is only partially explained by common risk factors. Markers of cardiovascular autonomic dysfunction (CVAD), such as orthostatic hypotension and increased resting heart rate, are strongly associated with CAD. The autonomic nervous system also innervates the airw

first_pageDownload PDFsettingsOrder Article ReprintsOpen AccessArticleDiagnostic Performance of Clinical and Routine Laboratory Data in Acute Mesenteric Arterial Occlusion—An International Multicenter Studyby Yasmin Soltanzadeh-Naderi 1ORCID,Annika Reintam Blaser 2,3ORCID,Martin Björck 2,4,Alexandre Nuzzo 5ORCID,Joel Starkopf 2,6,Alastair Forbes 2,Marko Murruste 2,6ORCID,Kadri Tamme 2,6ORCID,Peep

Background:Acute mesenteric venous thrombosis (MVT) is rarely suspected as primary diagnosis in emergency departments and still carries an in-hospital mortality rate of above 20%.Objectives:The aim of this study was to find differences in clinical and laboratory markers between patients with acute MVT and a control group of suspected but confirmed as not having any type of acute mesenteric ischaem

This chapter discusses how the official religious policies stipulated in the so-called Document 19 issued by the Central Committee of the Chinese Communist Party in 1982 have transformed into the current religious laws and policies under Xi Jinping. Therefore, it analyses the most recent amendment (2017) of the Religious Affairs Regulations (RAR), Administrative Measures for Religious Groups (2020

As late as in the 1970s, the evidence supporting that brain function might be restored by replacing dead cells by transplantation of new healthy cells was scarce in experimental animals and lacking in humans. Repairing the human brain was regarded as completely unrealistic by clinicians. Fifty years later, the situation is very different, and cellular grafting has reached patient application in se

This paper examines the history of entrepreneurship education (EE) in the United Kingdom (UK), exploring different forms and types as they have emerged over time. The study uses a wide range of sources, including both secondary (e.g. published papers, historical records of specific programmes, and enterprise policy documents) and primary accounts that document the lived experience of educators. It

This article addresses the problem of multi-target localization from acoustic time delay measurements in a 3-D underwater environment, taking into account the depth-dependent sound speed of the underwater wave propagation. Specifically, we formulate the problem as an optimal mass transport (OMT) optimization over a grid of potential candidate positions. By exploiting an iterative refinement approa

There is a growing call for comparative analyses of forest governance to facilitate knowledge exchange for the sustainable management of Nordic forest systems, addressing the needs of societal stakeholders in enhancing both the quality and quantity of forest resources. This study traces the development of nation-wide policy instruments implemented in four Nordic countries; Finland, Sweden, Norway

Repair and replacement strategies using cell replacement or viral gene transfer for neurologic diseases are becoming increasingly efficacious with clinically meaningful benefits in several conditions. An increased understanding of disease processes opens up opportunities for genetic therapies and precision medicine methods aiming at disease modification or repair of lesioned neurologic structures.

A person’s life chances and quality of life depend on social class distinctions, but more so on the region one grew up in. Perspectives of the ‘urban’ or ‘metropolitan’ are a starting point when discussing geographical inequalities vis-à-vis rural, peripheral regions. How disrupting these problems and challenges are on the one (urban) and the other (rural) end of the geographical scope depends on