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Incretin-based therapy is associated with low risk of hypoglycemia in type 2 diabetes mellitus (T2DM) possibly due to its glucose-dependency in stimulating insulin secretion and a sustained glucagon response during hypoglycemia. This is of special relevance when it is combined with insulin or given to elderly patients since both insulin therapy and high age are associated with impaired glucagon co

Modeling is fundamental to both feed-forward and feedback control. Within automated anesthesia the two paradigms are usually referred to as target-controlled infusion (TCI) and closed-loop drug delivery, respectively. In both cases, the objective is to control a system with anesthetic drug infusion rate as input, and (measured) clinical effect as output. The input is related to the output through

The setting (distance between mantle and concave ring) of the Hydrocone cone crusher is altered, even with the crusher operating at full load, by lifting or lowering the mantle by means of a hydraulic piston (Hydroset). Modern developments in the field of electronics and microcomputers have made it possible to design a small, reliable and very sophisticated system for automatic regulation of the s

Climate change brings new burdens to people working outdoors. Migrantpopulations working at brick kilns in India are one such group facing dangerouslyoverheated working conditions. Many migrate to the kilns from rural areas underbonded labor conditions. We argue that solutions need to go beyond industry oriented technology-based solutions and focus on the social problem and take apeople focused st

In this study, we compared the GR51PP (hydrophobic/polysulfone) membrane with a series of hydrophilic (regenerated cellulose) membranes with the aim of increasing the retention of products and decreasing membrane fouling. The raw material used was a sodium-based spent sulfite liquor from the sulfite pulping process of spruce and pine. The results show that the hydrophilic membranes were superior t

The Learning with Errors problem (LWE) is one of the main candidates for post-quantum cryptography. At Asiacrypt 2017, coded-BKW with sieving, an algorithm combining the Blum-Kalai-Wasserman algorithm (BKW) with lattice sieving techniques, was proposed. In this paper, we improve that algorithm by using different reduction factors in different steps of the sieving part of the algorithm. In the Rege

Removing obstacles to e-commerce in the Single Market and ensuring effectivetaxation in the context of the digital economy has been high on the political agendaboth in the European Union and beyond. Recently the VAT rules on cross-border ecommerce have gone through a thorough modernisation with a package of newprovisions in the EU VAT legislation coming into effect as of 2019 and 2021. Furthermeas

Body temperature control is essential for survival. In mammals, thermoregulation is mediated by the preoptic area of anterior hypothalamus (POA), with ∼30% of its neurons sensitive to brain temperature change. It is still unknown whether and how these temperature-sensitive neurons are involved in thermoregulation, because for eight decades they have only been identified via electrophysiological re

An improved solution of the non-linear and ill-posed inverse problem of electro-cardiography is presented. The hearts activity is modeled by three di®erent equivalent cardiac sources: 1 moving dipole, 2 and 5 fixed location rotating dipoles. For this purpose a three dimensional volume conductor model of the human body is constructed based on a classical anatomic atlas. This is excited by each one

The introduction of high efficiency and multifunctional equipment for road survey increase not only the quality but also the possibility of integration of different source of data to increase the value of the information. The present research work, starting from a common data source, the Automatic Road Analyzer (ARAN) of the University of Catania, shown as data surveyed with ARAN can be used to de

Background. Rheumatoid arthritis (RA) is characterized by an uncontrolled spread of destructive joint inflammation resembling malignancy. Epidemiological studies have established strong correlation between inflammation and predisposition for cancer. Here we assess the predictive role of the circulating proto-oncogene survivin for clinical and radiological outcome of early RA. Patients and methods.

When addressing infants, adults use a speech register known as infant-directed speech (IDS). Compared to adult-directed speech (ADS), IDS has a number of distinctive acoustic and linguistic features. Vowel hyperarticulation, the expansion of the acoustic space between the corner vowels /i,u,a/, is one feature specifically proposed to facilitate language acquisition processes. Interestingly, the pr

Soot particles undergo considerable changes in composition, morphology, as well as in internal structure during formation from the incipient particles to more mature aggregates, and still there is a lack of understanding of these mechanisms. In this study, soot produced by a mini-CAST soot generator was probed using Raman spectroscopy with focus on soot with large variation in size and fraction of

The optical band gap has been used considerably in evaluating carbon network structures in terms of sp 2 /sp 3 sites and size of aromatic clusters. However, optical band gap determination of soot particles from optical measurements is complex due to the effects of other species including organic compounds, and the contribution of absorption from organics to the total soot absorption in the UV/visi

Objectives. Despite accumulating research on yoga and its positive impact on both physiological and psychological health, it is still unclear how yoga improves health. Two central components of yoga: yogic breathing and mindfulness, may be important mechanisms by which individuals learn to cope with their daily stressors, and thereby reduce their risk of developing stress-related illness. In this ObjectivesDespite accumulating research on yoga and its positive impact on both physiological and psychological health, it is still unclear how yoga improves health. Two central components of yoga, yogic breathing and mindfulness, may be important mechanisms by which individuals learn to cope with their daily stressors, and thereby reduce their risk of developing stress-related illness. In this st

In this paper we address the problem of resource allocation for alarm traffic in industrial Internet of Things networks using massive MIMO. We formulate the general problem of how to allocate pilot signals to alarm traffic such that delivery is guaranteed, while also minimising the number of pilots reserved for alarms, thus maximising the channel resources available for other traffic, such as indu