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Accumulating evidence suggests mitochondria as key modulators of normal and premature aging, yet whether primary oxidative phosphorylation (OXPHOS) deficiency can cause progeroid disease remains unclear. Here, we show that mice with severe isolated respiratory complex III (CIII) deficiency display nuclear DNA damage, cell cycle arrest, aberrant mitoses, and cellular senescence in the affected orga
Background and Purpose: Target delineation in glioblastoma is still a matter of extensive research and debate. This guideline aims to update the existing joint European consensus on delineation of the clinical target volume (CTV) in adult glioblastoma patients. Material and Methods: The ESTRO Guidelines Committee identified 14 European experts in close interaction with the ESTRO clinical committee
Tumor cells evolve in tumor microenvironment composed of multiple cell types. Among these, endothelial cells (ECs) are the major players in tumor angiogenesis, which is a driver of tumor progression and metastasis. Increasing evidence suggests that ECs also contribute to tumor progression and metastasis as they modify their phenotypes to differentiate into mesenchymal cells through a process known
By 2050, seven billion people will be living in cities. In 2020 itself, these cities dumped a whopping 29 trillion tonnes of carbon dioxide into the atmosphere. This carbon dioxide along with other greenhouse gases poses a serious health hazard. It also manifests as extreme weather events, leading to the loss of lives, livelihoods, assets, and social wellbeing.Given the significant impact that cit
Det är en debattartikel där författarna argumenterar för att stora fysiska samlingar är inte ett obetingat religiöst krav, även om det är något som många längtar efter. Man bör vara försiktiga med att åberopa religionsfrihetsargumentet när det gäller att utkräva olika typer av rättigheter, såsom mässfirande i större grupper under en pandemi.
Författaren besvarar tidningsläsarnas chattfrågor om coronaviruset. Kan det smitta via luften? Och vilka är de vanligaste sätten att bli smittad på, med mera.
We consider planar Coulomb systems consisting of a large number nn of repelling point charges in the low temperature regime, where the inverse temperature β grows at least logarithmically in n as n→∞, i.e., β≳logn.Under suitable conditions on an external potential, we prove results to the effect that the gas is with high probability uniformly separated and equidistributed with respect to the corr
In this paper, we empirically and theoretically present regenerative regional development in responsible value chains as an alternative to the prevailing traditional, neoliberal economic rationale of globalization. We develop the argument on the back of a longitudinal in-depth case study on actors’ engagement in the recurring crises in the maritime industry in Sunnmøre/Norway. The alternative pers
INTRODUCTION: Neurological complications after surgery for acute type A aortic dissection (ATAAD) increase patient morbidity and mortality. Carbon dioxide flooding is commonly used in open-heart surgery to reduce the risk of air embolism and neurological impairment, but it has not been evaluated in the setting of ATAAD surgery. This report describes the objectives and design of the CARTA trial, in
The APOE4 variant of apolipoprotein E (apoE) is the most prevalent genetic risk allele associated with late-onset Alzheimer's disease (AD). ApoE interacts with complement regulator factor H (FH), but the role of this interaction in AD pathogenesis is unknown. Here we elucidate the mechanism by which isoform-specific binding of apoE to FH alters Aβ1-42-mediated neurotoxicity and clearance. Flow cyt
Normal science is a characterization of science in our epoch and a demarcation of what “scientific” means. It divides science in disciplined/normed paradigms. Mathematical epidemiology is the paradigm that regulates the activity of mathematicians with respect to the study of epidemics. It also represents the interest (multiple meanings implied) of the community that guards it. In contrast, a real
Host-pathogen protein-protein interactions are highly complex and dynamic and mediate key steps in pathogen adhesion to host, host invasion, and colonization as well as immune evasion. In bacteria, these interactions most often involve specialized virulence factors or effector proteins that specifically target central host proteins. Here, I present a mass spectrometry-based proteomics approach sta
My ongoing work on the lived experiences of young adult migrants is phenomenological research aimed at the process of social resilience and social experiences of young adult migrants. I'm conducting unstructured interviews to learn more about the phenomenon's textural (what was experienced) and structural (how it was experienced) characteristics. In these unstructured interviews, I emphasize the m
Clay soils can cause significant distress in road construction due to their low strength. Stabilizing such soil improve with binder agents prior to the geotechnical works can significantly its performance and ensure safety and stability of roads while exploitation. This research envisaged the use of five different binders (lime, energy fly ash, bio fly ash, slag, cement) as an additive stabilizing
The effect of 3,4,9,10-perylenetetracarboxylic dianhydride (PTCDA) adsorption on the physical properties of the two-dimensional (2D) atomic layer superconductor (ALSC) In/Si(111)-(7×3) has been studied by angle-resolved photoelectron spectroscopy, transport measurements, and scanning tunneling microscopy. Hole doping from the adsorbed molecules has been reported to increase the superconducting tra
Investigations on epitaxial nanostructures with size of tens of nanometers have been a challenging issue for techniques that present high strain sensitivity but restricted spatial resolution. This is the case of recently developed x-ray nanoprobe techniques. Despite its inherent nondestructive character, submicron x-ray spots have only been successfully applied to the study of individual nanostruc
We present a Bayesian method to reconstruct event-by-event multiplicity fluctuations and rapidity correlations in p+Pb collisions at zero impact parameter from minimum-bias data, without assuming any model of the collision dynamics. We test it on Monte Carlo simulations with the Angantyr model, then apply it to ATLAS data on the distribution of charged multiplicity and transverse energy in p+Pb co
Epidemiological studies have associated plasma galectin-4 (Gal-4) levels with prevalent and incident diabetes, and with an increased risk of coronary artery disease. To date, data regarding possible associations between plasma Gal-4 and stroke are lacking. Using linear and logistic regression analyses, we tested Gal-4 association with prevalent stroke in a population-based cohort. Additionally, in
Even though urban cemeteries in Sweden today can be seen as making space for different memorial practices, they are also a materialization of certain cultural and religious norms (Kjaersgaard & Venbrux, 2016), which sometimes are expressed as functional and aesthetic values. In this respect, the urban cemetery has an abiding attitude to change in building on past traditions and designs to addrEven though urban cemeteries in Sweden today can be seen as making space for different memorial practices, they are also a materialization of certain cultural and religious norms (Kjaersgaard & Venbrux, 2016), which sometimes are expressed as functional and aesthetic values. In this respect, the urban cemetery has an abiding attitude to change in building on past traditions and designs to addr
BACKGROUND: Precision medicine has the potential to improve cardiovascular disease (CVD) risk prediction in individuals with type 2 diabetes (T2D).METHODS: We conducted a systematic review and meta-analysis of longitudinal studies to identify potentially novel prognostic factors that could improve CVD risk prediction in T2D. Out of 9380 studies identified, 416 studies met inclusion criteria. Outco
