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BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with limited treatment options, illustrating an urgent need to identify new drugable targets in PDACs.OBJECTIVE: Using the similarities between tumor development and normal embryonic development, which is accompanied by rapid cell expansion, we aimed to identify and characterize embryonic signaling pathways that

Background and AimsWater scarcity and poor water quality could lead to suboptimum menstrual hygiene practices, and subsequently urinary tract infection (UTI) and bacterial vaginosis (BV). In this study, we estimate the prevalence of self-reported UTI and BV among indigenous adolescent girls during the water scarcity period in the Bandarban Hill Districts in south-eastern Bangladesh.MethodsUsing a

This paper presents a model for micron-sized aluminum (Al) particle combustion in hot oxidizing environments, forming hollow spheres. The model comprises four sub-models describing the physical and chemical processes during Al combustion: melting of the solid core, ejection of liquid Al droplets from the breaking solid shell, vaporization of liquid droplets, and ignition and establishment of vapor

Introduction: Several studies have addressed technical aspects of endovascular thrombectomy (EVT), but it is not well known how procedural factors contribute to technical success in routine healthcare. The aim was to explore factors associated with technically successful EVT on nationwide scale. Methods: We did an observational register-based study assessing factors associated with technical succe

Probabilistic solvers provide a flexible and efficient framework for simulation, uncertainty quantification, and inference in dynamical systems. However, like standard solvers, they suffer performance penalties for certain stiff systems, where small steps are required not for reasons of numerical accuracy but for the sake of stability. This issue is greatly alleviated in semi-linear problems by th

The article explores the use of reflexive methodology to enhance mixed methods queer psychological research in Sweden, by analysing data from a qualitative research project on how LGBTQ people cope with minority stress from four epistemological perspectives. A descriptive, hermeneutically and phenomenologically inspired analysis showed that coping should be understood from temporal perspective, wh

The nonionic surfactant pentaethylene glycol-monododecylether C12E5 forms micelles in aqueous solutions with a lower critical solution temperature. This characteristic solution behavior of C12E5 is independent of the pH. Such micelles are used to solubilize a large variety of active guest molecules like for instance dyestuffs. An example is an acidic azo dye termed Blue used as a hair colorant. De

Key performance indexes (KPIs) in various forms have always been used in one way or another in the production and processing of raw materials. The need for KPIs was accentuated with the advent of industrialism in the western world. The way and strategy of manufacturing industrial products has been divided into several so-called developmental transformations. Primarily after the depression of the 1

This publication describes a concept that intends to enable an optimization of machining with regard to the balance between criteria related to technology, economy and sustainability. The work is of a discussion nature and intends to provide a framework for further research and development in the area. Previous research and development during the 80's and 90's is presented in general terms and in

BACKGROUND AND PURPOSE: The treatment landscape for patients with advanced non-small cell lung cancer (NSCLC) has evolved significantly since the introduction of immunotherapies. We here describe PD-L1 testing rates, treatment patterns, and real-world outcomes for PD-(L)1 inhibitors in Sweden. MATERIALS AND METHODS: Data were obtained from the Swedish National Lung Cancer Registry for patients wit

Introduction: Early recognition of pain in children is crucial, and their self-report is the primary source of information. However, communication about pain in healthcare settings can be challenging. For non-verbal communication regarding different symptoms, children prefer digital tools. The electronic Faces Thermometer Scale (eFTS) utilizes a universal design with colors, face emojis, and numbe

A continuously growing and mutating market with increasing demands on environmental sustainability, illuminated by unraveling environmental threats, highlights the need for greater resource efficiency in modern manufacturing industries. Machining has become pivotal in the pursuit of sustainability given its superior efficiency in manufacturing of metallic products. In theory, the efficiency of a m

In medical and biomedical education, traditional teaching methods often struggle to engage students and promote critical thinking. The use of AI language models has the potential to transform teaching and learning practices by offering an innovative, active learning approach that promotes intellectual curiosity and deeper understanding. To effectively integrate AI language models into biomedical e

We explain how the accelerating field amplitude and phase vary with modulator voltage in pulsed radio frequency high-power amplifiers based on klystron tubes. Changes in modulator voltage give rise to correlated changes of amplitude and phase, affecting the properties of the accelerated beam, in particular energy, arrival time, and bunch duration. We show, both theoretically and experimentally, th

Objective. To examine the changes in health-related quality of life (HRQoL) in patients with coronary artery disease (CAD) in terms of age, gender, and treatment strategy in Iran. Methods and Materials. Forty-nine patients responded to the Iranian version of the 36-item short form (SF-36) questionnaire to evaluate the HRQoL at first and third year after treatment. The paired and independentWilcoxo