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Background: Nonsuicidal self-injury (NSSI) is a serious health risk behavior that forms the basis of a tentative diagnosis in DSM-5, NSSI Disorder (NSSID). To date, established treatments specific to NSSI or NSSID are scarce. As a first step in evaluating the feasibility, acceptability, and utility of a novel treatment for adolescents with NSSID, we conducted an open trial of emotion regulation in

Restoring lost bone is a major challenge in orthopedic surgery. Currently available treatment strategies have shortcomings, such as risk of infection, nonunion, and excessive resorption. Our primary aim was to study if a commercially available gentamicin-containing composite calcium sulfate/hydroxyapatite biomaterial (GBM) could serve as a carrier for local delivery of bone morphogenic protein-2 (

Massive parallel sequencing (MPS) is increasingly used for human identification purposes in forensic DNA laboratories. Forensic DNA samples are by nature heterogeneous and of varying quality, both concerning DNA integrity and matrices, creating a need for assays that can handle low amounts of DNA as well as impurities. Commercial short tandem repeat (STR) analysis kits for capillary electrophoresi

Background: No previous studies have evaluated the performance of the Synergy stent in a large real-life population. Objectives: To describe the initial real-life experience with a novel everolimus eluting platinum chromium stent with abluminal biodegradable polymer (SYNERGY) in unselected patients from a nationwide registry. Methods: All implanted Synergy stents were compared with other new gener

This paper presents a study of the role that photography of 14 October 1973 and 6 October 1976 has played in political mobilization around the two events. It is well known that in official archives limited versions of the events can be found. We must turn to alternative repositories (private homes, non­states organisations, but also universities and libraries outside of Thailand) to find the antic

8000 years ago, prior to Neolithic agriculture, Europe was mostly a wooded continent. Since then, its forest cover has been progressively fragmented, so that today it covers less than half of Europe's land area, in many cases having been cleared to make way for fields and pasture-land. Establishing the origin of Europe's current, more open land-cover mosaic requires a long-term perspective, for wh

Astrocytes play an important role in glutamatergic neurotransmission, namely by clearing synaptic glutamate and converting it into glutamine that is transferred back to neurons. The rate of this glutamate–glutamine cycle (VNT) has been proposed to couple to that of glucose utilization and of neuronal tricarboxylic acid (TCA) cycle. In this study, we tested the hypothesis that glutamatergic neurotr

Recently, many genome-wide profiling studies provided insights into the molecular make-up of major cancer types. The deeper understanding of these genetic alterations and their functional consequences led to the discovery of novel therapeutic opportunities improving clinical management of cancer patients. While tissue-based molecular patient stratification is the gold standard for precision medici

The main challenge in predicting structure-borne sound in wood buildings is to accurately model the vibration transmission between the source and the receiving room. Large variations in model parameters make it difficult to predict absolute vibration levels and to make conclusions regarding the relative effects of different designs. A step towards establishing reliable models is to investigate the

In ultrarelativistic heavy-ion collisions, the event-by-event variation of the elliptic flow v2 reflects fluctuations in the shape of the initial state of the system. This allows to select events with the same centrality but different initial geometry. This selection technique, Event Shape Engineering, has been used in the analysis of charge-dependent two- and three-particle correlations in Pb–Pb

Animal diversification on Earth has long been presumed to be associated with the increasing extent of oxic niches. Here, we challenge that view. We start with the fact that hypoxia (<1-3% O2) maintains cellular immaturity (stemness), whereas adult stem cells continuously - and paradoxically - regenerate animal tissue in oxygenated settings. Novel insights from tumour biology illuminate how cell st

Germanium solar cells are used as bottom subcells in many multijunction solar cell designs. The question remains whether the thermal load originated by the growth of the upper layers of the multijunction solar cell structure affects the Ge subcell performance. Here, we report and analyze the performance degradation of the Ge subcell due to such thermal load in lattice-matched GaInP/Ga(In)As/Ge tri

A non-local gradient-enhanced damage-plasticity formulation is proposed, which prevents the loss of well-posedness of the governing field equations in the post-critical damage regime. The non-locality of the formulation then manifests itself in terms of a non-local free energy contribution that penalizes the occurrence of damage gradients. A second penalty term is introduced to force the global da

Purpose – The purpose of this paper is to describe five salient factors that emerge in two successful change processes in healthcare. Organizational changes in healthcare are often characterized by problems and solutions that have been formulated by higher levels of management. This top-down management approach has not been well received by the professional community. As a result, improvement proc