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OBJECTIVES: This study investigates the expansion of CAR T-cells and its association to treatment outcome.METHODS: Patients with aggressive B-cell lymphomas treated with anti-CD19 CAR T-cell therapy axicabtagene ciloleucel (axi-cel) at Skåne and Sahlgrenska University Hospitals from 2019 to October 2024 were included. CAR T-cells in peripheral blood were measured by flow cytometry. Association bet

Jag undersöker den ideala krigar-mannen i två av Gamla testamentets profetböcker: Jesaja och Jeremia. Här beskrivs han som misslyckad och sårbar och i metaforer liknas han till exempel vid en kvinna som föder barn. Under perioden för böckernas tillkomst inträffade en katastrof för folket i Juda, den babyloniska exilen innebar att landet erövrades av stormakten Babylonien och att delar av folket tvThis book explores how the prophets Isaiah and Jeremiah depict warriors as vulnerable. In the oracle sections of these prophetic books, vivid imagery shows the warriors failing—not only in their duties as mighty men—but also in living up to the expectations of militarised masculinity. They are presented through imagery of cowardice, weakness, pain, and fear and are often portrayed as women, partic

Even if much is known regarding the effects of internet-delivered cognitive behaviour therapy (ICBT) for depression there are several topics that have not been studied. In this factorial design trial with 197 participants we investigated if clients in ICBT could select treatment modules themselves based on a selection of 15 tailored treatment modules developed for use in ICBT for depression. We co

BACKGROUND/OBJECTIVES: Given the risk of a progression, or an undiagnosed endometrial cancer (EC), the treatment of choice is hysterectomy in women with endometrial intraepithelial neoplasia (EIN). The risk of metastatic disease and whether sentinel node (SLN) biopsy should be performed remains unclear. The primary aim of this prospective study was to determine the overall incidence of concurrent

Goal-directed mental processes focused on oneself often co-occur with goal-directed mental processes focused on other people or objects. However, little is known about the mechanisms of this fundamental type of cognitive interaction. The aim of this study was to determine the degree of cognitive interference associated with self-related processing compared with other-related processing. In two sep

Dopamine D2 receptors (D2-R) in extrastriatal brain regions are of high interest for research in a wide range of psychiatric and neurologic disorders. Pharmacological competition studies and test-retest experiments have shown high validity and reliability of the positron emission tomography (PET) radioligand [11C]FLB 457 for D2-R quantification in extrastriatal brain regions. However, this radioli

This special issue addresses questions of how the practices of (welfare) state practitioners and policy makers (trans)form the lives of families. The aim is to illuminate how social policies and educational institutions influence parents’ hope for the wellbeing and future success of their children through new forms of audit culture and policies of early interventions. We invited contributions that

Limited and poor delivery of antibiotics is cited as one reason for the difficulty in treating antibiotic-resistant biofilms associated with chronic infections. We investigate the effectiveness of a positively charged, single isomer cyclodextrin derivative, octakis[6-(2-aminoethylthio)-6-deoxy]-γ-CD (γCys) to improve the delivery of antibiotics to biofilms. Using multiphoton laser scanning microsc

Det er tydeligt, at globale diskurser om sund og succesfuld aldring (se bl.a. Lamb 2014 og 2017) har fundet vej ind i den lokale drejebog for, hvad der udgør det optimale livsforløb (Oxlund 2018). Med fokus på fysisk aktivitet og individuel optimering har ideerne om sund aldring været med til at løfte barren for, hvad den enkelte forventes at investere i for både at føje år til livet og liv til år

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The growing accumulation and mismanagement of waste disrupt the ecological systems that sustain human existence, leaving environmental burdens for future generations. This situation highlights the need for circular approaches such as zero-waste management, where waste is treated as a resource rather than discarded. Studying social waste relations in Sweden is particularly relevant, given the count

Polar growth and cell shape determination in mycelium-forming Streptomyces bacteria depends on the function of a polarly localised multiprotein complex that directs cell wall synthesis – the polarisome. This complex assembles around the essential cell polarity determinant DivIVA, alongside other largely unknown components. We report here the discovery of a conserved hybrid histidine kinase-like pr

This study investigated the retention of spatial knowledge in buildings following route-learning training in a virtual reality environment. A total of 121 participants were tested up to three months later on putting waypoints of the route in the correct order and recalling directions at waypoints. Memory accuracy declined over time, consistent with classic memory theory. Route knowledge was retain