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Children are entitled to an economic standard that is comparable with the standard that their parents have. This principle is reflected in the child’s right to receive an addition to the average maintenance allowance, a so-called standard addition. In year 2013, the Supreme Court stated that a child who lives alternately with their parents are entitled to a maintenance allow-ance. By applying arti
Syftet med denna undersökning har varit att kunna se ifall det finns ett samband mellan pressfriheten och korruptionsnivåerna i Botswana och Zimbabwe. Genom att undersöka hur pressfriheten eventuellt har påverkat korruptionsnivåerna i Botswana och Zimbabwe är målet att finna förklaringsfaktorer till varför korruptionsnivån är högre i länder med begränsad pressfrihet och då i huvudsakligen i Botswa
År 2011 kom det första auktoritära ”soft law” dokumentet inom området företag och mänskliga rättigheter,”UN Guiding Principles on Business and Human rights”. I detta dokument åläggs företag ett ansvar att respektera mänskliga rättigheter genom att använda sig av en s.k."human rights due diligence" (HR DD). Denna ska bl.a. innehålla en "root cause analysis" för att överensstämmaIn 2011, the UN Guiding Principles (UNGPs) became the first authoritative international standard regarding the field of business and human rights. The document states a responsibility for companies to respect human rights. The operational principle of due diligence in the UNGPs is designed as a tool for companies to use in order to be able to respect human rights. However, if the due diligence is
Rapporten består av en policy-analys gällande internationella, nationella, regionala och lokala (Malmö och Göteborg) policys som berör bilfria urbana distrikt eller implementering av sådana områden. Detta arbete är en del av projektet ”Bilfria urbana distrikt”, som är ett gemensamt forskningsprojekt mellan Lunds universitet, Sveriges landsbruksuniversitet (SLU) och Chalmers i Göteborg. Dokumenten
Specialized epitope tags are widely used for detecting, manipulating or purifying proteins, but often their versatility is limited. Here, we introduce the ALFA-tag, a rationally designed epitope tag that serves a remarkably broad spectrum of applications in life sciences while outperforming established tags like the HA-, FLAG®- or myc-tag. The ALFA-tag forms a small and stable α-helix that is func
Aim To present a systematic literature review (SLR) on efficacy, immunogenicity and safety of vaccination in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD), aiming to provide a basis for updating the EULAR evidence-based recommendations. Methods An SLR was performed according to the standard operating procedures for EULAR-endorsed recommendations. Outcome was determined by
Context. In the era of large high-resolution spectroscopic surveys such as Gaia-ESO and APOGEE, high-quality spectra can contribute to our understanding of the Galactic chemical evolution by providing abundances of elements that belong to the different nucleosynthesis channels, and also by providing constraints to one of the most elusive astrophysical quantities: stellar age. Aims. Some abundance
The LHC Higgs data are showing a gradual inclination towards the standard model (SM) result, and realization of a SM-like limit becomes essential for beyond the SM scenarios to survive. Considering the accuracy that can be achieved in future colliders, models beyond the standard model that acquire the alignment limit with a SM-like Higgs boson can surpass others in the long run. Using a convenient
Renovating the European building stock has for almost two decades been a matter of importance to the European Union. Reduction of energy use for existing buildings can be achieved through applying energy efficiency renovation measures. Besides this, there is quite a large renovation need in Sweden due to building materials and services reaching (or having passed) the end of their service life.IncoRenovating the European building stock has for almost two decades been a matter of importance to the European Union. Reduction of energy use for existing buildings can be achieved through applying energy efficiency renovation measures. Besides this, there is quite a large renovation need in Sweden due to building materials and services reaching (or having passed) the end of their service life.Inco
Heritage buildings are usually culturally protected as well as naturally ventilated. As such, it is difficult to control the airflow, which depends on the temperature outdoors as well as the wind. This causes issues with the thermal comfort and the indoor air quality. In this study, status determinations were conducted for 12 heritage buildings with offices, across Sweden. Field measurements on te
1-(Benzothiazol-2-yl)-1-(4-chlorophenyl)ethanol (1) was identified as a positive allosteric modulator (PAM) of the CaSR in a functional cell-based assay. This compound belongs to a class of compounds that is structurally distinct from other known positive allosteric modulators, for example, the phenylalkylamines cinacalcet, a modified analog (13) potently suppressed parathyroid hormone (PTH) relea
Synthesis of substituted 4-benzyloxypyridinium salts by the addition of Grignard reagents to pyridine N-oxides provides an efficient route for obtaining substituted 4-pyridones or 4-aminopyridinium salts.
Addition of Grignard reagents to pyridine N-oxides in THF at low temperature (-78 to -20 °C) and treatment with TFAA provides an efficient general procedure for synthesis of substituted pyridines. The method is compatible with a range of functional groups such as esters, halogens and nitriles.
(Figure presented) A conceptually new one-pot strategy for the synthesis of protected substituted piperazines via the addition of Grignard reagents to pyrazine N-oxides is presented. This strategy is high yielding (33-91% over three steps), step-efficient, and fast. The synthesized N,N-diprotected piperazines are convenient to handle and allow for orthogonal deprotection at either nitrogen for sel
We report the discovery and initial characterization of a novel class of selective NPFF2 agonists. HTS screening using R-SAT, a whole cell based functional assay, identified a class of aryliminoguanidines as NPFF1 and NPFF2 ligands. Subsequent optimization led to molecules exhibiting selective NPFF2 agonistic activity. Systemic administration showed that selective NPFF2 agonists (1 and 3) are acti
Herein we describe the discovery of ACP-105 (1), a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone. Compound 1 was developed from a series of compounds found in a HTS screen using the receptor selection and amplification technology (R-SAT). In vivo, 1 improved anabolic parameters in a 2-week chro
(formula presented) Temporary tethering using aluminum or zinc in Diels-Alder reactions made possible the use of otherwise "noncompatible" combinations of dienes and dienophiles, resulting in the one-step formation of substituted cyclohexene 1,2-bis-methanols. Excellent regioselectivity and also significant stereoselectivity were obtained.
(Matrix Presented) A new one-pot procedure for the synthesis of substituted pyrrolidine derivatives with commercially available cyclopropyl ketones, aldehydes, and amines by a metal iodide promoted three-component reaction was developed.
