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Background: Scintigraphy of the renal cortex with technetium-99m labelled dimercaptosuccinic acid (99mTc-DMSA) is well established in the follow-up of pyelonephritis in children. This method allows detection of focal defects of renal function, as well as measurement of the relative contribution of each kidney to total renal function - split renal function (SRF). Within nuclear medicine, the long t
Background Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition influenced by both genetic and environmental factors. Prenatal and perinatal exposures have been implicated in ASD etiology, but their influence may vary across clinical subgroups, including subgroups defined by co-occurring intellectual disability (ID). Methods We conducted a population-based case–control st
Background: This study evaluates deep learning (DL) using gene expression (GEX) and preoperatively available clinical data (PreopClinic) to predict sentinel lymph node macro-metastasis (SLNM), and explores their potential for guiding axillary surgery de-escalation and supporting prognostic assessment.Methods: We retrospectively included 6,836 clinically node-negative (cN0) T1-T2 patients with inva
The genus Mentha is highly valued in pharmaceutical, culinary, and personal care industries due to its rich aromatic and pharmacological traits. However, its complex taxonomy and genetic diversity create challenges for breeding programs focused on aroma and therapeutic qualities. To address these challenges, this study developedand validated a rapid, semi-quantitative metabotyping method to efficiThe genus Mentha is highly valued in pharmaceutical, culinary, and personal care industries due to its rich aromatic and pharmacological traits. However, its complex taxonomy and genetic diversity create challenges for breeding programs focused on aroma and therapeutic qualities. To address these challenges, this study developedand validated a rapid, semi-quantitative metabotyping method to effici
Att sluta begå brott handlar inte enbart om förändrade handlingar, utan också om hur individer omformulerar vem de är. Denna avhandling analyserar hur unga personer med erfarenhet av kriminalitet konstruerar och förhandlar sina identiteter i berättelser om brottsdebut, fortsatt brottslighet och upphörande med brott. Avhandlingen behandlar tre centrala frågor: (1) Vilka innehållsmässiga komponenterIn this thesis I explore how young people with a criminal record choose to construct and negotiate their identities in narratives about debut offences, re-offending, and desistance. I address three key questions: (1) What content-related components are central to young people’s narratives of desistance? (2) What linguistic and cultural resources do young people draw on to present themselves as cre
An abdominal aortic aneurysm (AAA) is defined as aortic diameter ≥30 mm measured by ultrasound. AAA prevalence increases with age and is higher in men, but has decreased during the last decades, related to lower smoking rates. Tobacco smoking, concomitant atherosclerosis, arterial hypertension, and family history are the most common risk factors. AAA has atherosclerotic, inflammatory, apoptotic, a
Water-related damage represents a major challenge in the built environment, with consequences for building performance and occupant health. While external factors can contribute, this study focuses on damage originating from internal sources. Deficiencies and failures in building service systems, water supply, sewage, and technical installations, constitute a substantial problem, leading to repair
This paper studies cone-preserving linear discrete-time switched systems whose switching is governed by an automaton. For this general system class, we present performance analysis conditions for a broadly usable performance measure. In doing so, we generalize several known results for performance and stability analysis for switched and positive switched systems, providing a unifying perspective.
Municipalities shoulder the burden of creating business-friendly environments – managing infrastructure, navigating public resistance, and investing countless hours in smoothing the path for economic development. Yet, the rewards often flow elsewhere. Local taxes on economic activity offer a powerful solution. While a thriving local economy boosts budgets, different taxes shape municipal decision-
Despite substantial progress in Remote Sensing (RS)-based estimation of Water Quality Parameters (WQPs) using Machine Learning (ML) models, there remains a lack of end-to-end software that automates the entire workflow. To address this gap, this paper introduces WQEye (v1), an open-source software offering a user-friendly interface comprising six modular components: (1) Data loader; (2) RS samplin
The development of an N-body/hydrodynamic ‘surrogate’ model of the Milky Way (MW) – a model that resembles the MW in several key aspects after many Gyrs of evolution – would be extremely beneficial for Galactic Archaeology. Here, we present four new ‘surrogate’ models, all built with the nexus framework. The simulations contain stars, dark matter and gas. Our most sophisticated model allows gas to
Background: The prevalence of urinary incontinence (UI) and fecal incontinence (FI) are conditions that increase with age. Apart from few larger studies data on prevalence and severity of UI and FI is scarce, especially among the > 80 yrs. and data of birth cohort effects is lacking. Methods: The purpose of this study was to evaluate birth cohort effects on prevalence of UI and FI in the general o
Climate litigation has been on the rise since the beginning of the century. However, the increased use of intersectionality by plaintiffs to highlight their particular vulnerability to climate change and its impacts remains understudied. This paper provides a review of eleven intersectional climate litigation cases, along with insights from a focus group of key informants, to examine the role of i
In 2021, neutron structures of oxidised and reduced human manganese superoxide dismutase were published, suggesting several unexpected features, including deprotonated glutamate, tyrosine and histidine residues and a reduced Mn ion with two hydroxide ligands. We have used quantum refinement to evaluate whether alternative interpretations of the structures are possible, comparing many structural mo
Populärvetenskaplig sammanfattning:Elfordon uppfattas ofta som en modern uppfinning, men elektriskt drivna fordon har funnits sedan slutet av artonhundratalet. De första helelektriska personbilarna, bussarna och lastbilarna utvecklades redan innan förbränningsmotorn slog igenom.För att förstå varför elektriska störningar spelar en så viktig roll i dagens elfordon kan man börja med en enkel bild. TThe rapid electrification of heavy-duty vehicles has introduced traction voltage systems (TVS) with electrical scale and complexity not previously seen in on-road applications. Multiple power electronic subsystems interact through long cables and frequency-dependent impedances, making conducted electromagnetic interference (EMI) a system-level phenomenon. Differential-mode (DM) and common-mode (CM
The built environment faces a growing functional mismatch in which a persistent affordable housing shortage coincides with rising office vacancy rates. In this context, adaptive reuse is approached in this thesis not only as a strategy for reassigning underused space, but as a building physics and building performance challenge tied to changing the use of existing buildings. The overall objective
