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Background: Cost-effectiveness models in Parkinson’s disease often include health states based on Hoehn and Yahr (H&Y) and time in ‘off’. Few studies have investigated utilities in these health states. Objective: The aim of this study was firstly to explore utilities in health states based on H&Y and off-time, and secondly to investigate to what extent H&Y and off-time correlated with
Knowledge of how to design digital systems that are ergonomically sound, high in usability, and optimized for the user, context, and task has existed for some time. Despite this, there are still too many examples of new digital health care systems that are poorly designed and that could negatively affect both the work environment of health care staff and patient safety. This could be because of a
This study critically evaluates David Harvey’s model of urban land rent and its centrality in his explanation of the material forces that underlie and limit urban land policies, strategies, planning decisions, and investment choices. Harvey emphasizes structural forces of capital in relating economic urbanization processes to uneven patterns of capitalist development, recurrent economic crises of
In pulmonary arterial hypertension, plexiform lesions are associated with severe arterial obstruction and right ventricular failure. Exploring their structure and position is crucial for understanding the interplay between hemodynamics and vascular remodeling. The aim of this research was to use synchrotron-based phase-contrast micro-CT to study the three-dimensional structure of plexiform lesions
The aim of this article is to provide an evolutionarily grounded explanation of central aspects of the structure of language. It begins with an account of the evolution of human causal reasoning. A comparison between humans and non-human primates suggests that human causal cognition is based on reasoning about the underlying forces that are involved in events, while other primates hardly understan
Background: The aim of this study was to examine the effect of household food security on childhood anemia inBangladesh while controlling for socioeconomic and demographic factors.Methods: We used nationally representative Bangladesh Demographic Health Survey (BDHS) 2011 data for thisstudy, the only existing survey including anemia information and household food security. The sample included2171 c
En översiktlig analys av nazismens uppkomst och ideologi.
En biografi om Djingis khan.
Purpose: Twenty-first century crises reaffirm the need of faster mobilization of resources during crises. Without interorganizational collaboration and resource mobilization, organizing efficient response is not possible. Resource mobilization is an essential aspect of response. It ensures a faster and better response. Collaboration between teams of emergency responders may include commonly known
The purpose of this paper is to study how the concept “middle archive” is related to the Swedish archival theory and practice, by exploring its background and its practical and theoretical implications. The overarching aim is to increase the understanding of the interrelations between the archival theory and practice, with a special focus on changes occurring in the digital environment in Sweden.
Maculonaclia florida (de Joannis, 1906) has been one of the most mysterious moths of Mauritius, a small volcanic island located some 900 km east from Madagascar. Here, we reviewed its generic placement, phylogenetic relationships and the potential evolutionary scenarios leading to the current distribution of this unique Mauritian member of Syntomini. The species, known previously only from a few o
BACKGROUND: Contact allergy to fragrance mix I (FM I) is over-represented in patients photoallergic to ketoprofen. The prevalence of contact allergy to two components of FM I, cinnamal and cinnamyl alcohol, in ketoprofen-photoallergic patients is higher than in dermatitis patients.OBJECTIVE: To explore the prevalence of contact allergy to FM I and its individual components in patients with photoco
Migraine is one of the most common of neurological disorders with a global prevalence of up to 15%. One in five migraineurs have frequent episodic or chronic migraine requiring prophylactic treatment. In recent years, specific pharmaceutical treatments targeting calcitonin gene-related peptide (CGRP) signalling molecules have provided safe and effective treatments; monoclonal antibodies for prophy
X-ray propagation-based imaging techniques are well established at synchrotron radiation and laboratory sources. However, most reconstruction algorithms for such image modalities, also known as phase-retrieval algorithms, have been developed specifically for one instrument by and for experts, making the development and diffusion of such techniques difficult. Here, PyPhase, a free and open-source p
PURPOSE: Despite impressive response rates following adoptive transfer of autologous tumor-infiltrating lymphocytes (TILs) in patients with metastatic melanoma, improvement is needed to increase the efficacy and broaden the applicability of this treatment. We evaluated the use of vemurafenib, a small-molecule BRAF inhibitor with immunomodulatory properties, as priming before TIL harvest and adopti
