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Computational methods gained a widespread use in drug discovery. Understanding conformational dynamics of protein and mechanisms of protein-ligand binding are two major areas in drug discovery. Molecular dynamics (MD) simulation have been routinely used to study conformational dynamics of protein and mechanisms of protein-ligand binding. In classical MD simulation, the system often remains stuck i
Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly genotyped) and 375,188 controls identified 54 significant (P < 5 × 10-8) loci with 68 independent single nucleotide polymorphisms. Analysis of risk estimates across geographical regions and host factors suggests the acral melanoma sub
BACKGROUND: Tremor is a cardinal symptom of Parkinson's disease (PD) that may cause severe disability. As such, objective methods to determine the exact characteristics of the tremor may improve the evaluation of therapy. This methodology study aims to validate the utility of two objective technical methods of recording Parkinsonian tremor and evaluate their ability to determine the effects of Dee
The presence of paralytic shellfish poisoning toxins (PSTs) in drinking water resources has urged the development of simple and fast screening tools for drinking water surveillance. This article aims to validatea quick test kit for freshwater PSTs detection. Preliminary estimates of the limit of detection (LODs)were done for 5 PSPs variants, namely C1 toxin (a “C” toxin); GTX5(a Gonyautoxin); and
This article investigates how regulation related to maintaining state registration and tax beneficial status affects professionalisation, covering paid staff and volunteers with specialist skills, of political parties, advocacy groups and service providing organisations. The article fills a gap in the literature which until now has been mainly concerned with the influence of state funding on profe
The paper discusses the underlying characteristics of Macedonian illiberal politics during the 11-year rule of the centre-right party VMRO-DPMNE (2006–2017) focusing on two aspects: institutional and symbolic. We argue that the unfair political competition was enabled by the weakness of pre-existing institutions and the population’s clientelist preferences, which were systematically exploited and
Turism dominerar alltmer det sociala livet i städerna. Detökade flödet av turister till vissa storstäder i Europa lämnarefter sig problem kopplat till trängsel, nedskräpning, trafik,prissättning på bostäder och missnöjesyttringar bland lokalastadsbor.Överturism beskriver ett tillstånd när det kommer så mångaturister till en plats att det får negativ påverkan på såvällokalbefolkningens livskvalitet
Background: Retrospective studies on MRI-only radiotherapy have been presented. Widespread clinical implementations of MRI-only workflows are however limited by the absence of guidelines. The MR-PROTECT trial presents an MRI-only radiotherapy workflow for prostate cancer using a new single sequence strategy. The workflow incorporated the commercial synthetic CT (sCT) generation software MriPlanner
Background: Long term β-blocker therapy after myocardial infarction (MI) reduces mortality and recurrent MI but evidence for this treatment predates contemporary acute coronary care. β-blocker treatment is a key quality of care indicator in the Swedish national quality register for acute coronary care, Riks-HIA. Between 2011 and 2015 a declining number of MI-patients discharged with a β-blocker fr
