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MuA transposase protein is a member of the retroviral integrase superfamily (RISF). It catalyzes DNA cleavage and joining reactions via an initial assembly and subsequent structural transitions of a protein-DNA complex, known as the Mu transpososome, ultimately attaching transposon DNA to non-specific target DNA. The transpososome functions as a molecular DNA-modifying machine and has been used in
Popular Abstract in Swedish Receptbelagda lugnande läkemedel används i behandling av framför allt ångest och sömnbesvär och har i det sammanhanget stor betydelse. Dessvärre kan beroende av dessa läkemedel utvecklas. Det förekommer även så kallad felanvändning av dessa läkemedel, d.v.s. användning utan recept, eller i högre doser, mer ofta, eller för annat syfte, än vad läkare har ordinerat. Sådan Background: Prescription sedatives are efficient in the treatment of anxiety and sleeping disorders, but are associated with a risk of misuse and dependence, as well as an increased risk of accidents, injuries and overdoses, both in the general population and especially in individuals with other substance misuse. The present thesis aims to investigate prescription sedative use and misuse in two ki
We investigate the time periodic solutions to the viscous Burgers equation $u_t -mu u_{xx} + uu_x = f$ for irregular forcing terms. We prove that the corresponding Burgers operator is a diffeomorphism between appropriate function spaces.
Med nya metoder som fältflödesfraktionering kan effekter av tillverkning och tillagning på lösliga kostfibers egenskaper följas. Genom att mäta genuttryck i blodkroppar efter en måltid kan man också få kunskap om fibrernas påverkan på ämnesomsättningen i kliniska studier.
Popular Abstract in Swedish Under de senaste årtiondena har prestandan i elektriska kretsar växt i en rasande takt. Detta har lett till otaliga innovationer som har förbättrat samhället. Grunden till denna utveckling grundar sig i två uppfinningar: transistorn och den integrerade kresten. Till skillnad från många andra grundläggande elektroniska komponenter har en transistor tre elektroder. En eRecent decades have seen an exponential increase in the functionality of electronic circuits, allowing for continuous innovation, which benefits society. This increase in functionality has been facilitated by scaling down the dimensions of the most important electronic component in modern electronics: the Si-based MOSFET. By reducing the size of the device, more transistors per chip area is possib
In mesoscopic and nanoscale systems at low temperatures, charge carriers are typically not in thermal equilibrium with the surrounding lattice. The resulting, non-equilibrium dynamics of electrons has only begun to be explored. Experimentally the time-dependence of the electron temperature (deviating from the lattice temperature) has been investigated in small metallic islands. Motivated by these
Evidence from clinical studies and animal models show that inflammation can lead to the development of depression. Macrophage migration inhibitory factor (MIF) is an important multifunctional cytokine that is synthesized by several cell types in the brain. MIF can increase production of other cytokines, activates cyclooxygenase (COX)-2 and can counter-regulate anti-inflammatory effects of glucocor
Whereas the language development of children with sensorineural hearing impairment (SNHI) has repeatedly been shown to differ from that of peers with normal hearing (NH), few studies have used an experimental approach to investigate the consequences on everyday communicative interaction. This mini review gives an overview of a range of studies on children with SNHI and NH exploring intra- and inte
Abstract in UndeterminedNuclear quadrupole resonance (NQR) is a non-invasiveradio-frequency technique allowing for a practically unique%ngerprint for molecules containing quadrupolar nuclei,making the technique very promising for detection purposes.If properly excited, these nuclei will emit electromagnetic radiation,the frequency of which is governed mainly by wherein the molecule the nuclei are
Combination therapies with inhaled corticosteroids (ICS) and either long-acting ß2 agonists (LABA) or leukotriene receptor antagonists (LTRA) are commonly used to help patients maintain control of their asthma. LABA and LTRA have different mechanisms of action and both provide complementary benefits when combined with ICS. This paper compares the two regimens based on recent clinical trial data, e
The transmembrane topology of the Acr3 family arsenite transporter Acr3 from Bacillus subtilis was analysed experimentally using translational fusions with alkaline phosphatase and green fluorescent protein and in silico by topology modelling. Initial topology prediction resulted in two models with 9 and 10 TM helices respectively. 32 fusion constructs were made between truncated forms of acr3 and
A study was undertaken to provide data on growth, feed conversion ratio (FCR) and faecal discharge of yellowtail kingfish (Seriola lalandi) fed three commercial diets used previously to culture this species in New Zealand. Fish were raised in tanks from 0.4 to 1.2 kg over the spring (water temperature 14–17°C) and summer (17–22°C) periods. There were considerable differences in volumetric and mass
The possibility of directly converting non-neuronal cells into neurons in situ in the brain would open therapeutic avenues aimed at repairing the brain after injury or degenerative disease. We have developed an adeno-associated virus (AAV)-based reporter system that allows selective GFP labeling of reprogrammed neurons. In this system, GFP is turned on only in reprogrammed neurons where it is stab
Chronic Obstructive Pulmonary Disease (COPD) is a respiratory disease characterized by chronic inflammatory response in the airways and lung parenchyma that involves the influx of inflammatory, structural cells and mediators. The inflammatory process resulting in lung tissue destruction, emphysema, includes the excess of uninhibited proteases released from inflammatory cells. alpha1-antitrypsin (
Understanding the land use history has proven crucial for the conservation of biodiversity in the agricultural landscape. In southern Sweden, very small and fragmented areas of the disturbance-dependent habitat xeric sand calcareous grassland support a large number of threatened and rare plants and animals. In order to find out if historical land use could explain variation in present-day habitat
Invasive lobular carcinoma (ILC) is the second most frequently occurring histological breast cancer subtype after invasive ductal carcinoma (IDC), accounting for around 10% of all breast cancers. The molecular processes that drive the development of ILC are still largely unknown. We have performed a comprehensive genomic, transcriptomic and proteomic analysis of a large ILC patient cohort and pres
