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Activation of the kallikrein-kinin system promotes vascular leakage, inflammation, and neurodegeneration in ischemic stroke. Inhibition of plasma kallikrein (PK) – a key component of the KKS – in the acute phase of ischemic stroke has been reported to reduce thrombosis, inflammation, and damage to the blood-brain barrier. However, the role of PK during the recovery phase after cerebral ischemia is
Despite decades of promising preclinical validation and clinical translation, ischemic stroke still remains as one of the leading causes of death and disability worldwide. Within its complex pathophysiological signatures, thrombosis and inflammation, that is, thromboinflammation, are highly interconnected processes leading to cerebral vessel occlusion, inflammatory responses, and severe neuronal d
Street experiments are proliferating in cities worldwide and have emerged as an approach to transform urban mobility and public space. Previous research attests to the broad spectrum of street experimentation and its variety of stakeholders, aims, methods, and impacts. In this article, we probe this multi‐faceted nature through a study of the landscape of street experimentation as it evolved in on
(1) Background: Patients’ experiences and satisfaction with their treatment are becoming increasingly important in the context of quality assurance, but the measurement of these parameters is accompanied by several disadvantages such as poor cross-country comparability and methodological problems. The aim of this review is to describe and summarize the process of measuring, publishing, and utilizi
Background: Glatiramer acetate (GA) is a well-established treatment option for patients with clinically isolated syndrome and relapsing–remitting multiple sclerosis (MS) with few side effects. The double transgenic mouse model spontaneous opticospinal encephalomyelitis (OSE), based on recombinant myelin oligodendrocyte glycoprotein35-55 reactive T and B cells, mimicks features of chronic inflammat
Neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein-antibody-associated disease (MOGAD) are antibody mediated CNS disorders mostly affecting the optic nerve and spinal cord with potential severe impact on the visual pathway. Here, we investigated inflammation and degeneration of the visual system in a spontaneous encephalomyelitis animal model. We used double-tra
Low-grade superficial connective tumors are a heterogeneous group of benign/reactive, intermediate—locally aggressive and intermediate—rarely metastasizing lesions arising in skin and subcutaneous/superficial soft tissues. The most common targets for fine needle aspiration (FNA) in this group of lesions are schwannomas, desmoids, and “pseudosarcomatous lesions” such as nodular fasciitis. Experienc
Objective: Progressive multiple sclerosis is characterized by chronic inflammation with microglial activation, oxidative stress, accumulation of iron and continuous neurodegeneration with inadequate effectiveness of medications used so far. We now investigated effects of iron on microglia and used the previously identified neuroprotective antipsychotic clozapine in vitro and in chronic experimenta
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune-inflammatory CNS disease affecting spinal cord and optic nerves, mediated by autoantibodies against aquaporin-4 (AQP4) and myelin-oligodendrocyte-glycoprotein (MOG). Effects of those immunoglobulins (Ig) on retina and optic nerve are incompletely understood. We investigated AQP4-IgG and MOG-IgG sera on retina and optic nerve ex vivo a
The main use of splenic fine needle aspirations (FNAs) is to diagnose primary tumors or tumorlike lesions including metastases and to assess splenic involvement of some hematopathological disorders. This chapter deals with disorders likely to be encountered in FNAs from the spleen in everyday practice.
In patch testing, a standardized manner of testing and of patch test reading is essential. In this chapter, the basic aspects of these issues are discussed, as well as thoughts on when patch testing should be probably, with what to patch test, especially considering the baseline series, and pitfalls when patch test reading.
Early cathedrals in Lund and DalbyThe aim of the article is to present and critically re-evaluate the written end material sources concerning the early cathedrals of Lund and Dalby in Scania, former medieval Denmark and now part of Sweden. The main questions are where and when did exist cathedrals in Scania in the 11th Century, how were their architecture, how can they be dated, and why were there
Was bedeutet es als Christ in einer Gesellschaft nicht zur Mehrheit zu gehören? Welche Aufgaben erwachsen hieraus, und wie gewinnt das Christentum seine gesellschaftliche Stimme? Eingeleitet und herausgegeben von Esther-Maria Guggenmos zeigen Beiträge von Alumni des KAAD durch Fallstudien aus Kenia, Vietnam, Thailand, Georgien, China, den Philippinen, dem Iran und zu den indigenen Völkern, welche
