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The autosomal dominantly inherited east Texas bleeding disorder is linked to an A2440G variant in exon 13 of the F5 gene. Affected individuals have normal levels of coagulation factor V (FV) activity, but demonstrate inhibition of global coagulation tests. We demonstrated that the A2440G mutation causes upregulation of an alternatively spliced F5 transcript that results in an in-frame deletion of
Arginine-rich cell penetrating peptides (ARCPPs) are known to quickly permeate cell membranes through a non-endocytotic pathway. Potential clinical applications of this facility have prompted enormous effort, both experimental and theoretical, to better understand how ARCPPs manage to overcome the prodigious thermodynamic cost of lipid bilayer permeation by these highly charged peptides. In this w
This paper presents an application of multiple linear regression (MLR) to extract significant correlations between damping of electromechanical modes and system operating conditions and to forecast future damping values, based on existing day-ahead market forecasts for power flows and generation. The presented analysis uses measurements from the Nordic power system. First, a static MLR model is de
The extent of remediation of contaminated industrial sites depends on spatial heterogeneity of contaminant concentration and spatially explicit risk characterization. We used sequential Gaussian simulation (SGS) and indicator kriging (IK) to describe the spatial distribution of polycyclic aromatic hydrocarbons (PAHs), pH, electric conductivity, particle aggregate distribution, water holding capaci
Popular Abstract in English Resistant to drug induced apoptosis and uncontrolled proliferation are biggest hurdles of cancer treatment. Bcl-3 is a proto-oncogene involved in both survival and proliferation in numerous cancers. In this thesis we investigated the molecular mechanisms through which Bcl-3 facilitates the survival and proliferation of cancer cells, furthermore we aimed to identify the Bcl-3 is a proto-oncogene and belongs to the inhibitor of κB (IκB) family and is known to be upregulated in numerous cancers. Bcl-3 can initiate transcription of different genes involved in cell survival and cell growth. Cell proliferation is achieved through binding of Bcl-3 to cyclin D1 promoter and facilitates the rapid transition from G1 to S phase. The aim of this thesis was to investigate th
Dopamine replacement therapy is useful for treating motor symptoms in the early phase of Parkinson's disease, but it is less effective in the long term. Electrical deep-brain stimulation is a valuable complement to pharmacological treatment but involves a highly invasive surgical procedure. We found that epidural electrical stimulation of the dorsal columns in the spinal cord restores locomotion i
The aim of my thesis has been to characterize genetically pediatric T-cell acute lymphoblastic leukemia (T-ALL). Articles I and II focus on molecular characterization of translocations involving T-cell receptor (TCR) loci. These types of aberration are characteristic for T-ALL and have previously proved pivotal in the identification of genes implicated in leukemogenesis. The translocation t(12;14
Climate change poses a serious challenge to sustainable urban development worldwide. In Sweden, climate change work at the city level emerged in 1996 and has long had a focus on mitigating greenhouse gas emissions. City planners’ “adaptation turn” is recent and still ongoing. This paper presents a meta-evaluation of Swedish municipal adaptation approaches, and how they relate to institutional stru
We investigated the elemental composition of spores and hyphae of arbuscular mycorrhizal fungi (AMF) collected from two saline sites at the desert border in Tunisia, and of Glomus intraradices grown in vitro with or without addition of NaCl to the medium, by proton-induced X-ray emission. We compared the elemental composition of the field AMF to those of the soil and the associated plants. The spo
A fundamental problem in robotics is generating the motion for a task. How to translate a task to motion or a series of movements is a non-trivial problem. The complexity of the task, the structure of the robot, and the desired performance determine the sequence of movements, the path, and the course of motion as a function of time, namely the trajectory. As we discuss in this thesis, a trajectory
Popular Abstract in Swedish Uppskattningsvis 140–180 000 patienter i Sverige har förmaksflimmer. Den totala förekomsten är dock okänd eftersom vissa patienter också helt saknar symtom och därför inte har kännedom om sin sjukdom. Förmaksflimmer, som både kan vara kroniskt eller komma i attacker, innebär att förmaken inte aktivt pumpar ner blodet i hjärtats kammare. Istället sker mer okoordinerade sBackground: Oral antigoagulation treatment (OAT) with warfarin have a narrow therapeutic window and patients exhibit a highly variable doseresponse that is attributable to genetic, disease-related,and environmental factors as well as prescription and nonprescription drugs, dietary vitamin K and alcohol. The effect of warfarin treatement on blood coagulation is measured using international normaliz
Guanylate cyclase activating protein 1 (GCAP1) is a neuronal Ca2+ sensor (NCS) that regulates the activation of rod outer segment guanylate cyclases (ROS-GCs) in photoreceptors. In this study, we investigated the Ca2+-induced effects on the conformation and the thermal stability of four GCAP1 variants associated with hereditary human cone dystrophies. Ca2+ binding stabilized the conformation of al
The heat transfer characteristics of an impinging jet into a crossflow have been investigated by the liquid crystal thermography technique. The jet nozzle is circular and is inclined at 10 deg with respect to the target wall. In a turbulent flow regime, the effects of the jet Reynolds number, the velocity ratio, and the crossflow Reynolds number on the heat transfer are examined. The results show
Background: Familial clustering of incident prostate cancer and some cancers at other discordant sites has been reported. Less is known about familial clustering of fatal prostate cancer with any fatal discordant cancers. Estimates on familial aggregation based on mortality are free from bias of overdiagnosis. Patients and methods: We used the nationwide Swedish Family-Cancer Database to calculate
Objectives Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies (GWAS) on European subjects. Methods We performed a two-stage meta-analysis on more than 78 000 participants. In stage 1, we synthesised data from eight GWAS whereas data from 10 centres wer
Does plasticity contribute to adult cognitive development, and if so, in what ways? The vague and overused concept of plasticity makes these controversial questions difficult to answer. In this article, we refine the notion of adult cognitive plasticity and sharpen its conceptual distinctiveness. According to our framework, adult cognitive plasticity is driven by a prolonged mismatch between funct
Fluorescence diffuse imaging suffers from limited spatial resolution. In this letter, we report a scanning imaging approach to increase the resolution of fluorescence diffuse imaging using nonlinear fluorophores. The resolution of a linear flurophore was compared with nonlinear upconverting nanoparticles (NaYF4 : Yb3+ /Tm3+ ) in a tissue phantom. A resolution improvement of a factor of 1.3 was fou
This paper presents the development of a non-dimensional model of a continuous cross-flow atomic layer deposition (ALD) reactor with temporally separated precursor pulsing and a structured model-based methodology for scaling up the substrate dimensions. The model incorporates an ALD gas–surface reaction kinetic mechanism for the deposition of thin ZnO films from Zn(C2H5)2 and H2O precursors that w
Realistic radio channel models are crucial for the success of vehicle-to-vehicle (V2V) system investigations. In this paper, we summarize the important parameters for V2V channel models and describe relevant measurement campaigns. Also, we develop and evaluate an ns-3 simulation model of a realistic V2V channel model that is based on measurements in Sweden. The channel model incorporates the effec
High-yield uniform silver nanorices were synthesized by a facile polyol process without the introduction of shape-selected seeds. Nanorices exhibit two plasmon resonance peaks in the visible and near-infrared regions respectively due to their anisotropy. XRD patterns demonstrated the HCP phase coexists with the FCC phase in nanorices. The novel structure of nanorices was characterized by TEM study
