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The Perseverance rover landed in Jezero crater on Mars, which once contained a lake of liquid water. We report the rock properties encountered by Perseverance during a 10-kilometer traverse extending over 400 meters in elevation, from beneath Jezero's western sedimentary fan to the upper crater rim. These rocks consist of coarse-grained olivine, magnesium and iron carbonates, silica, and phyllosil

Objective: In the present study, we investigated the role of the gut–liver crosstalk in the pathogenesis of steatotic liver disease (SLD) induced by the compounding and deleterious effects of alcohol and metabolic risk factors, and explored the potential translational aspects of microbiome-based interventions. Design: The effects of combined exposure to alcohol and a high-fat, high-cholesterol die

The link between regional tau load and clinical manifestation of Alzheimer's disease (AD) highlights the importance of characterizing spatial tau distribution across disease variants. In typical (memory-predominant) AD, the spatial progression of tau pathology mirrors the functional connections from temporal lobe epicentres. However, given the limited spatial heterogeneity of tau in typical AD, at

In Swedish feminist debates of the 1960s and 1970s, the productive woman was frequently constructed as the binary opposite of the non-productive woman. The former was associated with liberation, moral integrity, and independence. The latter was characterized in terms of passivity, laziness, and dependence. By engaging in paid labour, or by otherwise demonstrating her contribution to the greater go

BACKGROUND: Post COVID-19 condition remains a complex and challenging issue, with diverse manifestations, despite accumulating research and clinical experience. Dyspnea is one of the most common symptoms reported in post COVID-19 condition. Cardiopulmonary exercise testing (CPET) offers a cohesive assessment of dyspnea and exercise limitations. The Nijmegen questionnaire is a form for assessment o

The paper combines a truthmaker semantics with a dispositional view of beliefs according to which they are dispositions of agents to act as if truthmakers obtain. This has a number of virtues in that it gives us (i) an exact semantics for belief reports; as well as plausible accounts of both (ii) epistemic closure and (iii) contradictory beliefs. In particular, it allows us to analyze knowledge in

Jerome of Stridon was one of the most important biblical exegetes in early Christianity. Analyzing letters as well as prefaces to biblical commentaries written by Jerome, this article discusses four criteria which he considered to be necessary for orthodox exegesis to take place: 1) education and learning; 2) studying the Scriptures as part of an ascetic lifestyle; 3) divine help; and 4) learning

Allergy, characterised by antibody responses of the IgE isotype, is a major health concern. The set of monoclonal human IgE used for studying the molecular mechanisms of allergies is limited. Single-cell sequencing offers opportunities to establish novel antibodies for researching, diagnosis, and treatment of allergies. We describe and exploit a pipeline for generating recombinant IgE directly fro

In recent years, Kalaallit Nunaat, as Greenland is known in Kalaallisut (Greenlandic), has come under ever intensifying scrutiny — featuring in debates about geopolitics, climate change and natural resources. As US interest in the island continues, the EU is now stepping into the fray, with Ursula von der Leyen, the president of the European Commission, poised to visit Greenland and the wider Arct

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with a polybacterial dysbiosis devoid of a known pathogen. Here, we report that HS patients mount IgA and IgG responses against skin colonizers, notably Porphyromonas uenonis (Pu), a rare species selectively enriched in severe disease. In these patients, Pu foci are detected in the epidermis, surrounded by IgA deposits