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Species of the Mycobacterium avium complex display two main colony morphologies, smooth transparent (SmT) and smooth opaque (SmO), where SmT is associated with human disease and antimicrobial resistance. Previous studies have suggested that smooth bacteria can reversibly switch between the transparent and opaque forms, but the mechanism underlying morphotype transition has remained unknown. Using
Three plant researchers describe in this book how plants emerged via the fusion of several different types of simple prokaryotic organisms and, through algae, evolved into land plants. During their evolution, they survived global ice ages, violent volcanic eruptions, and collisions with celestial bodies. The authors follow the development of landplants along various paths- some of which have ended
A 47-year-old woman with metastatic pancreatic adenocarcinoma, diagnosed five months earlier and treated with palliative chemotherapy, was admitted with fever, jaundice, and right upper quadrant pain consistent with ascending cholangitis. Treatment with antibiotics was initiated and an endoscopic retrograde cholangiography was performed, whereby a biliary stent was placed to relieve malignant bili
Objectives: SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss-of-function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes. Here we describe a novel dominant variant in SLC4A4 in patients wit
Background: T cell receptor (TCR) binding properties have been related to a wide range of pathological conditions, including infections, autoimmunity and cancer. Characterising the TCR repertoire is of great biomedical interest but it has been challenging due to its high structural diversity. Methods: In situ sequencing (ISS) is a suitable technique for spatial cell typing and linking gene pattern
Osteoarthritis (OA)-related meniscal degeneration involves complex interactions between oxidative stress and proteasomal dysfunction. However, the molecular drivers of regional meniscal vulnerability remain poorly defined. This study integrated multiple transcriptomic datasets from OA and control menisci to identify functional networks and hub genes by using weighted gene co-expression network ana
The dissociation of NO is a critical step in its catalytic reduction to N2, which is key to automotive exhaust treatment. Here, we examine the role of Rh atomic steps in the NO dissociation reaction under 0.05 mbar NO. We use a Rh crystal sample curved around the (111) direction and ambient-pressure X-ray photoelectron spectroscopy to probe different Rh surfaces subject to the very same reaction c
OBJECTIVES: We assessed the prevalence of neurodevelopmental disabilities (NDDs; cognition, cerebral palsy, vision/hearing, epilepsy), attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), developmental coordination disorder (DCD), behavior problems, and multimorbidity in a national cohort of children born extremely preterm (EPT, <27-week gestation) to provide a comprehe
Cognitive scientists Spelke and Kintzler (2007) and Carey (2009) identify objects, actions, space and numbers as “core domains of knowledge” that are essential for conceptualizing the world. Gärdenfors (2019, 2020) argues that objects, actions and space are characterized by invariances in sensory signals. In this paper, we extend the analysis of invariances to the domain of numbers (understood as
Background: Randomized trials have demonstrated that early anticoagulation after acute atrial fibrillation-associated ischemic stroke is safe and non-inferior to delayed initiation. Whether anticoagulation should be delayed in people with larger infarcts is uncertain. Aims: To investigate whether ischemic stroke infarct volume, measured precisely by segmentation, modifies the treatment effect of e
We employ small-angle x-ray and dynamic light scattering to investigate the microscopic structure and dynamics of dense suspensions of ultra-low crosslinked (ULC) poly(N-isopropylacrylamide) microgels. By probing the supercooled and glassy regimes, we characterize the relationship between the structure and dynamics as a function of effective volume fraction φ and probed length scale. We demonstrat
Many animals, such as birds and bats, are capable of migrating over vast distances to specific destinations. Remarkably, even insects such as the North American Monarch butterfly and the Australian Bogong moth undertake similarly long-distance migrations to specific sites. Here, we provide an overview of our current understanding of the migration of these insects and outline the sensory cues and n
We perform a validation analysis on the multipolar model of opinion dynamics. A general methodology for using the model on datasets of two correlated variables is proposed and tested using data on the relationship between COVID-19 vaccination rates and political participation in Sweden. The model is shown to successfully capture the opinion segregation demonstrated by the data and spatial correlat
Background Obstructive sleep apnea (OSA) is associated with cardiovascular morbidity; however, it remains unclear whether the apnea–hypopnea index (AHI) or the severity of nocturnal hypoxemia, in terms of oxygen desaturation index (ODI), is more relevant for the development of heart failure (HF). Methods We included 3590 participants from the Sleep Apnea Patients in Skaraborg Study (mean age 54.6
We investigate the ecological and evolutionary variables that best explain spatial diversity patterns of anuran amphibians in three of South America's most diverse and geographically widespread biomes: the Cerrado, Amazonia, and Atlantic Rainforest. We used Conditional Autoregressive Models to assess the potential influence of present-day climate (temperature and precipitation), historical climate
Rivers play a fundamental role in shaping the Earth’s surface and sustaining ecosystems. Accurate modeling and simulation of stream power are essential for understanding fluvial processes. As a measure of the energy exerted by overland flow, stream power possesses both magnitude and directional attributes. However, conventional simulation approaches based on scalar operations often neglect the dir
In this paper, a revisit to the topic of electromagnetic scattering by a randomly oriented obstacle is made.The focus is on a general polarization state of the incident field.Specifically, the left and right circular polarizations are treated. We derive the analytic expressions of the scattering observables, such as the orientational averages of the extinction, scattering and absorption cross sectIn this paper, a revisit to the topic of electromagnetic scattering by a randomly oriented obstacle is made. The focus is on a general polarization state of the incident field. Specifically, the left and right circular polarizations are treated. We derive the analytic expressions of the scattering observables, such as the orientational averages of the extinction, scattering and absorption cross se
Genetic analyses are now routinely used as an adjunct to traditional morphologic and immunohistochemical investigations in the diagnosis of many neoplasms, including soft tissue tumors. Many genetic features are strongly associated with morphologic features, and a rapidly growing subset of mutations promise to shed light on patient outcome. This chapter discusses major molecular pathogenetic featu
Research has hitherto presented Gotland as a region wherecorner post constructions dominated during the Middle Agesand stave constructions were used only for monumental buildings.Bulverket was a large wooden platform, erected in lakeTingstäde in the 1130’s with numerous wooden buildings,resembling a small town. Methods of construction of all fourtechniques in use at the time, indicate, however a d
