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High-grade serous ovarian carcinoma (HGSOC) is the most common subtype of ovarian cancer, often discovered in advanced stages and linked to poor survival. Due to high mortality rates, there is a need for novel treatment strategies. A promising new strategy is induction of ferroptosis, which has recently been shown to synergistically induce cell death in HGSOCs in combination with MTDH-SND1 protein
Ovarian cancer is the most lethal gynecological malignancy, with treatment heavily relying on platinum-based chemotherapy. However, resistance frequently develops, posing a major clinical challenge that underscores the need for new approaches. In this study, we investigated the phosphoproteomic landscape underlying cisplatin resistance, which remains poorly understood. A parental CAOV3 ovarian can
Bestämmelsen om tjänstefel återfinns i 20 kap. 1 § Brottsbalken vilket innebär att den som vid myndighetsutövning, uppsåtligen eller av oaktsamhet, åsidosätter vad som gäller för uppgiften genom handling eller underlåtenhet kan ställas till svars. Idag omfattas inte de kommunalt förtroendevalda i den högre beslutande förvaltningen av detta ansvar då de besitter ett partiellt ämbetsansvar. Detta paThe regulation on misuse of office can be found in chapter 20 § 1 of the Swedish Penal Code which means that a person who in the exercise of public authority, by act or by commission, intentionally or through carelessness, disregards the duties of his office can be held liable. Today, elected representatives cannot be held accountable for their decisions as they hold a partial responsibility. This
Toxin-producing Staphylococcus aureus can be present in raw milk and therefore in cheese made from raw milk. To determine the number and type of toxin producers in raw milk used for raw milk cheese production in Ireland, 117 samples of raw milk and related products from five raw milk suppliers, to four raw milk cheesemakers in the South of Ireland, were analysed for coagulase positive S. aureus. E
OBJECTIVE: To compare the outcome of patients operated on acutely for ruptured abdominal aortic aneurysms (AAA) or otherwise symptomatic aortic aneurysms in a university hospital and in two county hospitals by the same group of vascular surgeons. DESIGN: Retrospective study. SETTING: 1 university and 2 county hospitals, Sweden. SUBJECTS: 108 patients operated on urgently for AAA, 81 at the univers
Monitoring and regulation of fermentations is of a paramount industrial and academic importance in order to keep conditions optimal during the entire process. Established techniques employed today include HPLC and spectrophotometry, which both have the disadvantage that broth samples have to be drawn from the fermentor and that they often require sample pre-treatment. The objectives of this study
Abstract in UndeterminedSpatial data clearinghouses are one of the key features of a spatial data infrastructure (SDI). However, recent research indicates that few national clearinghouses function well, as the spatial data resources available cannot be satisfactorily accessed or optimally used. To improve the functionality, we propose that clearinghouses to be complemented with expert systems and
BACKGROUND: For 40 years cricoid pressure has been used to prevent regurgitation of gastric contents during induction of anaesthesia. Recent studies have emphasised use of more moderate force so as not to deteriorate ventilation or endotracheal intubation. This study was undertaken to assess the current practice and knowledge of cricoid pressure among anaesthesia personnel in southern Sweden. METH
Aims: To study the cumulative incidence of hospitalization for severe diabetic vascular complications in childhood onset type 1 diabetes patients with special regards to age at onset and gender. Methods: The Swedish Childhood Diabetes Register (SCDR) was linked to the Swedish Hospital Discharge Register up to 31 December 2004. The following diagnoses were traced: diabetic kidney disease, myocardia
OBJECTIVES: To examine pioglitazone as add-on to metformin and insulin secretagogues in patients with type 2 diabetes and inadequate glycaemic control and its effect on glycaemic control, surrogate measures of insulin sensitivity (adiponectin) and beta-cell function (proinsulin/insulin) and fluid retention.DESIGN AND SETTING: Prospective open-label study of 54 patients with type 2 diabetes and HbA
OBJECTIVES: Quantitative monitoring of human cytomegalovirus infections is helpful in determining appropriate antiviral management in patients who receive bone marrow transplants. We sought to design and evaluate a new cytomegalovirus capture hybrid polymerase chain reaction enzyme-linked immunosorbent assay (PCR-ELISA) in plasma and peripheral blood mononuclear cells to monitor cytomegalovirus in
Background: Although omic-based discovery approaches can provide powerful tools for biomarker identification, several reservations have been raised regarding the clinical applicability of gene expression studies, such as their prohibitive cost. However, the limited availability of antibodies is a key barrier to the development of a lower cost alternative, namely a discrete collection of immunohist
Background. A spectrum of cutaneous human papillomaviruses (HPVs) is detectable in nonmelanoma skin cancers, as well as in healthy skin, but the significance that the presence of these types of HPV DNA has for the pathogenesis of skin cancer remains unclear. Methods. We studied 349 nonimmunosuppressed patients with skin lesions (82 with squamous cell carcinomas, 126 with basal cell carcinomas, 49
Background: The androgen receptor A645D mutation has been described in one patient with ambiguous genitalia and one boy with normal phenotype. Objective: Because of this phenotypic variation, we screened a cohort of men from the general population (n = 293) as well as men with the following disorders of the genital tract for the mutation: men with prostate cancer (n = 89), testicular cancer (n = 8
Klimatkompensation genom skogsplantering i Globala Syd har blivit ett allt mer vanligt sätt för företag att åtgärda sina växthusgasutsläpp, och därigenom sälja produkter och tjänster med netto noll utsläpp. I Sverige går snabbmatsrestaurangen MAX Burgers AB ett steg längre. De kompenserar 10 % mer än vad de släpper ut genom carbon dioxide removal (CDR), och hävdar därför att de har en "klimatCarbon offsetting through forest sequestration in the Global South has become an increasingly common way for companies to mitigate their greenhouse gas emissions and thereby sell products and services with net zero emissions. In Sweden, fast food company MAX Burgers AB goes even further. They offset 10 % more than what they emit through carbon dioxide removal (CDR), thus claiming to have a “climat
Aim: To assess available evidence on the use of rFVIIa in non-orthopaedic surgery including dental surgery in adult patients with congenital haemophilia with inhibitors (PWHI). Methods: A systematic literature search was performed according to a prespecified search string; prespecified criteria were used to select applicable studies including PWHI ≥18 years of age who underwent any non-orthopaedic
Smoked ham is commonly eaten in Sweden. However, smoked ham consists of a lot of salt (NaCl) which is an important component in the brine. Since a high salt consumption increases the risk of cardiovascular diseases, it is of great interest to decrease salt and other sodium-binding compounds in various food products, especially in smoked ham. Nevertheless, this is a challenge because the salt and o
In the modern business environment, there is growing number of companies placing weight on sustainability-related issues, such as waste management, local communities, use of resources etc. At the same time such stakeholders as investors, consumers, employees and communities are increasingly interested in understanding company’s efforts and progresses in the area of sustainability. With that respec
