Filtyp
current strategies of primary stroke and cardiovascular disease prevention are aimed at addressing the main risk factors primarily in patients with higher cardiovascular disease risk. Since the number of people with incident stroke and ischaemic heart disease cases is rapidly growing across all countries of the world, this preventive strategy appears to be not sufficiently effective. World Stroke
In this paper we consider the case of planar motion, where a mobile platform equipped with two cameras moves freely on a planar surface. The cameras are assumed to be directed towards the floor, as well as being connected by a rigid body motion, which constrains the relative motion of the cameras and introduces new geometric constraints. In the existing literature, there are several algorithms ava
Recently, we reported an association between a SNP in IL28RA and MS. Here, we performed a fine-mapping of the IL28RA locus by genotyping 10 haplotype-tagging SNPs in a Basque-Spanish population. In addition, based on shared genetic risk loci between autoimmune diseases, a psoriasis-associated SNP located at this locus, rs4649203, was genotyped in four independent populations, comprising a total of
Plastics play an essential role in modern society, but also lead to significant impacts on the environment and climate. Reducing such impacts while retaining the usefulness of plastics requires a shift towards a more circular and sustainable plastics system. This report tells the story of plastics, and their effect on the environment and climate, and looks at their place in a European circular eco
The energy gap of correlated Hubbard clusters is well studied for one-dimensional systems using analytical methods and density-matrix-renormalization-group (DMRG) simulations. Beyond 1D, however, exact results are available only for small systems by quantum Monte Carlo. For this reason and, due to the problems of DMRG in simulating 2D and 3D systems, alternative methods such as Green functions com
Electrical impedance tomography (EIT) is a noninvasive imaging modality, where imperceptible currents are applied to the skin and the resulting surface voltages are measured. It has the potential to distinguish between ischaemic and haemorrhagic stroke with a portable and inexpensive device. The image reconstruction relies on an accurate forward model of the experimental setup. Because of the rela
A Mobile stroke unit (MSU) is a type of ambulance deployed to promote the rapid delivery of stroke care. We present a computational study using a time to treatment estimation model to analyze the potential benefits of using MSUs in Sweden’s Southern Health Care Region (SHR). In particular, we developed two scenarios (MSU1 and MSU2) each including three MSUs, which we compared with a baseline scena
Primary Sjögren’s syndrome (SjS) is a systemic autoimmune disease most commonly diagnosed in middle-aged women. Although the disease can occur at all ages, it is diagnosed between 30 and 60 years of age in two-thirds of patients. In more than 20% of cases, the people are older than 65 years. In this review, we focus on the therapeutic management of primary SjS in older patients, following the rece
Organised on the 16 November 2020, the roundtable on “Sharing Cities – Shaping Tomorrow” focused on sharing insights and ideas on the future of sharing in our cities and communities. The roundtable gathered over 40 people from around world and formed part of the Smart City Live Conference. This report pulls together the conversations at the roundtable and distils the key findings.
Given its emphasis on understanding marketing systems through their reciprocal interactions with society, the task of developing a methodology that captures such complexity is particularly crucial for macromarketing. The aim of the present contribution is to elaborate a methodological approach that is able to operationalize macromarketing complexity into more comprehensive and analyzable forms, wh
The Multi-Blade is a Boron-10-based gaseous detector introduced to face the challenge arising in neutron reflectometry at pulsed neutron sources. Neutron reflectometers are the most challenging instruments in terms of instantaneous counting rate and spatial resolution. This detector has been designed to cope with the requirements set for the reflectometers at the upcoming European Spallation Sourc
This paper sets up a framework for designing a massive multiple-input multiple-output (MIMO) testbed by investigating hardware and system-level requirements such as processing complexity, duplexing mode and frame structure. Taking these into account, a generic system and processing partitioning is proposed which allows flexible scaling and processing distribution onto a multitude of physically sep
We present a summary of the splinter session “Sun-like stars unlike the Sun” that was held on June 9, 2016, as part of the Cool Stars 19 conference (Uppsala, Sweden), in which the main limitations (in the theory and observations) in the derivation of very precise stellar parameters and chemical abundances of Sun-like stars were discussed. The most important and most debated processes that can prod
Adequate food packaging is important to ensure food quality and prolong the shelf life of food. Frequently, the method of modified atmosphere packaging (MAP) is used. We used a tunable diode laser spectroscopy technique to detect the oxygen content in food packages, e.g., in packaged milk and bread. Different detection geometries were adopted to be able to collect scattering light that had passed
Owing to its diagenetic instability, aragonite is rare in the geological record and almost entirely absent from pre-carboniferous sedimentary rocks. The former presence of this mineral in older deposits has to be inferred from petrographic, chemical or isotopic proxies. Crystals of aragonite that formed around 4563 million years ago occur in carbonaceous chondrite meteorites, showing that under ce
This article discusses the role of the protein corona in delivery systems with tagged nanoparticles and how knowledge of the protein corona can help in optimizing delivery. The basic question is whether and how the binding of proteins and other biomolecules at the nanoparticle surface interfere with the interaction between a tag and its receptor. This is an interesting problem in many respects, bu
Reduced pancreatic b-cell function or mass is the critical problem in developing diabetes. Insulin release from b-cells depends on Ca2+ influx through high voltage- gated Ca2+ channels (HVCCs). Ca2+ influx also regulates insulin synthesis and insulin granule priming and contributes to β-cell electrical activity. The HVCCs aremultisubunit protein complexes composed of a pore-forming a1 and auxiliar
