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Treatment for musculoskeletal disorders in primary care in Sweden is generally initiated with advice and medication. Second line therapy is physiotherapy and/or injection and radiography; third line therapy is referral to an orthopedist. Manual therapy is not routine. It is a challenge to identify patients who benefit from treatment by different specialists. The current referral strategy probably
Low-grade inflammation has been repeatedly associated with cardiovascular diseases but the relationship with incidence of atrial fibrillation (AF) remains unclear. We explored the association between elevated plasma levels of inflammation-sensitive proteins (ISPs) and incidence of AF in a population-based cohort. Plasma levels of five ISPs (fibrinogen, haptoglobin, ceruloplasmin, α(1)-antitrypsin
BACKGROUND: Decreased glomerular filtration rate is an established risk factor for bleeding but there are limited data on its association with bleeding risk in well-controlled anticoagulated patients taking warfarin. OBJECTIVES: The aim was to investigate the relationship between glomerular filtration rate, major bleeding and thromboembolic complications in patients with tight anticoagulation cont
Nitrogen (N) cycle dynamics and N deposition play an important role in determining the terrestrial biosphere's carbon (C) balance. We assess global and biome-specific N deposition effects on C sequestration rates with the dynamic global vegetation model LPJ-GUESS. Modeled CN interactions are evaluated by comparing predictions of the C and CN version of the model with direct observations of C fluxe
Introduction: The objective of the study was to investigate the impact of newer biologic treatments including rituximab, abatacept and tocilizumab on antibody response following pneumococcal vaccination using a 7-valent conjugate vaccine in patients with established rheumatoid arthritis (RA). Methods: Patients with RA receiving rituximab, abatacept or tocilizumab as monotherapy or combined with me
To examine the association of sialic acid (SA) with first recorded diabetes mellitus-related hospitalization.
The familial risk of medullary thyroid carcinoma (MTC alone or as part of multiple endocrine neoplasms, MEN2A/MEN2B) is high, so we aimed to answer open questions about the lifetime cumulative risk of thyroid cancer (LCRTC at 0-79 years) among relatives of MTC patients by age and sex. For this nationwide study, a cohort of 3217 first-/second-degree relatives (FDRs/SDRs) of 389 MTC patients diagnos
To describe the prevalence of, risk factors for, and prognostic importance of gastrointestinal (GI) bleeding and use of acid suppressants in acutely ill adult intensive care patients. We included adults without GI bleeding who were acutely admitted to the intensive care unit (ICU) during a 7-day period. The primary outcome was clinically important GI bleeding in ICU, and the analyses included esti
Purpose: To externally validate and compare the performance of previously published diagnostic models developed to predict malignancy in adnexal masses. Experimental Design: We externally validated the diagnostic performance of 11 models developed by the International Ovarian Tumor Analysis (IOTA) group and 12 other (non-IOTA) models on 997 prospectively collected patients. The non-IOTA models inc
AIMS: A history of preeclampsia is associated with at least a twofold increased risk of coronary artery disease (CAD), with unclear underlying mechanisms. This study aimed to investigate coronary plaque characteristics in women with a history of preeclampsia compared to women from the general population.METHODS: In this cross-sectional study, women with a history of preeclampsia from the Cardiovas
The first measurement of the e+e− pair production at midrapidity and low invariant mass in central Pb-Pb collisions at √sNN = 5.02 TeV at the Large Hadron Collider is presented. The yield of e+e− pairs is compared with a cocktail of expected hadronic decay contributions in the invariant mass (mee) and pair transverse momentum (pT,ee) ranges mee < 3.5 GeV/c2 and pT,ee < 8 GeV/c. For 0.18 < mee < 0.
Background and aims Secondary prevention medications after myocardial infarction (MI) are crucial for reducing mortality and cardiovascular events, however, adherence is often suboptimal. This study aimed to investigate predictors of adherence, and clinical outcomes among STEMI and NSTEMI survivors in Sweden. Methods This nationwide cohort study included patients hospitalized with MI between 2017
Introduction – Hand-arm vibration syndrome (HAVS) is a chronic disease to vessels and nerves caused by vibrations. In Sweden, the medical check-up for vibrations (MCV) implements the EU surveillance system to detect early cases. No earlier research has shown participation in MCVs, nor why MCVs is avoided. We aimed to improve the understanding on avoidance of MCVs among vibration-exposed workers. M
This study presents an integrated simulation framework that combines agent-based transport modeling with probabilistic load-flow analysis to quantify power system loading of long-haul heavy-duty electrification. The approach is applied to a case study considering fully electrified road freight in the Skåne region in Sweden, using high-resolution transport demand data and the actual power grid mode
Purpose: Genital malformations are increasingly recognized when a VACTERL is present, but remain insufficiently described in children with esophageal atresia (EA). This study aimed to determine the prevalence and spectrum of genital and urinary tract malformations in children with EA, and to describe associated morbidity, need for additional surgery, and association with Gross classification. Meth
INTRODUCTION: Cognitive impairment is common in parkinsonian disorders, but its extent among older adults with subtle motor abnormalities without a diagnosed movement disorder remains unclear. We examined cognitive decline, domain-specific cognitive function and incident dementia in older adults with subthreshold parkinsonism and parkinsonism (primary analysis). Sensitivity analyses were repeated
Objective: To assess which structural abnormalities on knee MRI are associated with development of osteophytes in middle-aged subjects without radiographic knee osteoarthritis. Design: We included subjects from the Osteoarthritis Initiative, aged 40–55 years, Kellgren & Lawrence grade 0 in both knees, and knee MRIs from both knees available at baseline, 24, 48 and 72 months. Structural exposur
Background: The majority of childhood cancer survivors are at risk of treatment-related adverse health outcomes. Survivorship care to mitigate these late effects is endorsed, but it is not available for many adult survivors of childhood cancer in Europe. The PanCareFollowUp project was initiated to improve their health and quality of life (QoL) by facilitating person-centred survivorship care. Met
Objectives: To investigate absolute and relative risk of serious infections in adult/elderly inflammatory bowel disease (IBD) diagnosed 2002–2017. Methods: Nationwide, register-based cohort study of Swedish patients with IBD compared with general population matched reference individuals with regard to time to first serious infection, equal to hospital admission. Multivariable Cox regression estima
(1) Background: Reconditioning of the paraspinal lumbar extensor muscles by isolated lumbar extension resistance exercises (ILEX) has shown good clinical results for patients with chronic unspecific low back pain. However, the clinical value and safety for patients with specific spine pathologies is unclear. In this study, clinical outcome and influencing factors were retrospectively analyzed for
