Filtyp
OBJECTIVE: Critical limb ischemia (CLI) is a peripheral arterial disease manifested by drastically diminished blood flow to the legs, pain at rest, nonhealing wounds, and gangrene caused by atherosclerosis. Significant tissue necrosis is associated with late stage CLI and the patients have a poor prognosis. Necrotic and apoptotic cells activate complement and bind complement inhibitor C4b-binding
Objectives The aim of this research is to study education, income and immigration as risk factors for high hemoglobin A1c (HbA1c >70 mmol/mol (8.6%)) when diagnosed with type 2 diabetes (T2D) or latent autoimmune diabetes in the adult (LADA). Research design and methods Patients were included from the All New Diabetics in Scania study (2008-2013). Level of education, disposable income and immigrat
Introduction: Airway obstruction and possible concomitant pulmonary diseases in COPD cannot be identified conventionally with any single diagnostic tool. We aimed to diagnose and grade COPD severity and identify pulmonary comorbidities associated with COPD with ventilation/perfusion single-photon emission computed tomography (V/P SPECT) using Technegas as the functional ventilation imaging agent.
Results from the radiological environmental monitoring of the European Spallation Source (ESS) are presented for year 2020.Among the 63 environmental samples analysed for gamma emitting radionuclides, no elevated levels of anthropogenic radioactivity were observed. All samples (except two samples of lichen) had activity concentrations below the MDA for the natural radionuclides as well as 137Cs, a
Patients with diffuse large B-cell lymphoma (DLBCL) who fail to complete planned treatment with R-CHOP due to toxicity are sparsely described. We investigated the extent of failure to complete treatment (six cycles or more, or three cycles + RT for patients with stage I disease) with R-CHOP for reasons unrelated to non-response, the determinants of such failure and the outcome among these patients
Patients who sustain an acute anterior cruciate ligament (ACL) rupture are at increased risk to develop posttraumatic arthritis (PTA) in the injured knee whether the ACL is reconstructed or treated nonoperatively. Inflammatory cytokines and cartilage degradation biomarkers are elevated at the time of acute injury and postoperatively. This suggests that one mechanism for PTA may be an inflammatory
This thesis seeks to explore the potential of extracting amusement from the utilitarian, and propose a design that aims to connect a vast industrial site with its immediate surroundings and the city. By investigating the design of a battery recycling plant that is to be built in Skellefteå, the thesis draws upon an actual situation to address a real world problem. 8 9 As there is no design yet fo
Invasion, mass warfare, foreign hordes, slaughter and pure evil. When pondering these words one will usually attribute them to the traditional conception of the barbarian, and not to something as seemingly distant as Western civilization. In this paper I aim to discuss the rare combination of liberal European civilization and its relation with barbarism in general, specifically focusing on the ca
This thesis has investigated the prevailing understanding of poor leadership as a major impediment to the democratization of the Democratic Republic of Congo. Analytical studies found evidences on the correlation between the authoritarian regimes installed in the Democratic Republic of Congo and the abortive process of democratization under the leadership of Mobutu Sese Seko and Laurent-Désiré Kab
This thesis investigates the main obstacles preventing PLWHA in Jamaica from accessing treatment. Currently the number of PLWHA accessing treatment in Jamaica is lower than would be expected. This research utilises qualitative data collection methods in order to canvass the views of a broad range of individuals involved in the fight against HIV in Jamaica. These include PLWHA, NGO workers, Civil
INTRODUCTION: Fetal cardiovascular magnetic resonance (CMR) imaging is used clinically and for research, but has been previously limited due to lack of direct gating methods. A CMR-compatible Doppler ultrasound (DUS) gating device has resolved this. However, the DUS-gating method is not validated against the current reference method for fetal phase-contrast blood flow measurements, metric optimize
Background: OncoMasTR is a new multigene prognostic test that was discovered via a novel transcriptional network analysis method that identified upstream Master Transcription Regulators (MTRs), which regulate previously identified prognostic biomarkers. The optimised OncoMasTR signature incorporating clinicopathological information has been shown to be significantly prognostic for predicting dista
Plastics are widely used in todays society leading to an accelerating amount of plastic waste entering natural ecosystems. Over time these waste products degrade to micro- and, eventually, nanoplastic particles. Therefore, the break-down of plastics may become a critical threat to aquatic ecosystems and several short term studies have demonstrated acute toxicity of nanoplastics on aquatic organism
Objectives: To examine the associations between physical fitness in male adolescents and coronary and carotid atherosclerosis in middle age. Methods: This population-based cohort study linked physical fitness data from the Swedish Military Conscription Register during adolescence to atherosclerosis data from the Swedish CArdioPulmonary bioImage Study in middle age. Cardiorespiratory fitness was as
BACKGROUND: The management of femoral neck fractures (FNF) in elderly patients depends on comorbidities, pre-fracture mobility, any hip joint disease, and life expectancy, with treatment typically involving either hemiarthroplasty (HA) or total hip arthroplasty (THA). While cemented femoral stem fixation is standard, there is no clear consensus regarding cemented versus cementless cup fixation in
Secondary lymphedema (LE) following breast cancer-related surgery is a life-long complication, which currently has no cure. LE induces significant regional adipose tissue deposition, requiring liposuction as a treatment. Here, we aimed to elucidate the transcriptional, metabolomic, and lipidomic signature of the adipose tissue developed due to the surgery-induced LE in short- and long-term LE pati
