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The discovery of the CRISPR-Cas9 system has revolutionized several areas of biological research by making genome engineering easy, affordable, fast, accessible and scalable. One field that has not yet benefited from this technological advance is that of mitochondrial DNA research. Study I addresses the challenges associated with adapting CRISPR-Cas9 to the mitochondrial environment, and identifies
BACKGROUND: The incidence of cutaneous malignant melanoma (CMM) and melanoma in situ (MIS) has been increasing during the last 50 years. Malignant melanoma (MM) is also the most common intraocular malignancy (IMM). Besides ultraviolet radiation, the cause of these tumours is largely unknown.OBJECTIVES: We designed a study to examine the effect of body mass index (BMI) and tobacco use on the risk f
Changes in the geometry of ocean meridional overturning circulation (MOC) are crucial in controlling past changes of climate and the carbon inventory of the atmosphere. However, the accurate timing and global correlation of short-term glacial-to-deglacial changes of MOC in different ocean basins still present a major challenge. The fine structure of jumps and plateaus in atmospheric and planktic r
Non-invasive imaging biomarkers (IBs) are warranted to enable improved diagnostics and follow-up monitoring of interstitial lung disease (ILD) including drug-induced ILD (DIILD). Of special interest are IB, which can characterize and differentiate acute inflammation from fibrosis. The aim of the present study was to evaluate a PET-tracer specific for Collagen-I, combined with multi-echo MRI, in a
Monitoring soil moisture at the Earth'surface is of great importance for drought early warnings. Spaceborne remote sensing is a keystone in monitoring at continental scale, as satellites can make observations of locations which are scarcely monitored by ground-based techniques. In recent years, several soil moisture products for continental scale monitoring became available from the main space age
Raney nickel-2H2O exchange reaction on an epimeric mixture of methyl α/β-D-ribofuranoside [α/β = ∼3:10]1 produced methyl 1#,2,3,4#,5,5′-2H6-α/β-ribofuranoside 2 [97 atom % 2H at C2, C3, C5/5′; ∼85 atom % 2H at C4 (C4#); ∼20 atom % 2H at C1(C1#)] which was obtained in 60 – 80 % yield along with epimeric xylo and arabino by-products. Toluoylation of the crude 2 in dry pyridine and a careful separati
How macroeconomic crises affect firms' environmental sustainability strategies is an open question. We study the impact of the Covid-19 pandemic on the environmental sustainability strategies of firms listed on the OMXNasdaq stock exchange in Sweden. The analysis is based on a survey distributed twice, once during the summer of 2020 and once during the summer of 2021 with detailed questions relate
Purpose: A new biodegradable liquid fiducial marker was devised to allow for easy insertion in lung tumors using thin needles. The purpose of this study was to evaluate the visibility of the liquid fiducial markers for image-guided radiation therapy and compare to existing solid fiducial markers and to one existing liquid fiducial marker currently commercially available. Methods: Fiducial marker v
Rationale: Amyloid-β (Aβ) pathology is one of the earliest detectable brain changes in Alzheimer’s disease pathogenesis. In clinical practice, trained readers will visually categorise positron emission tomography (PET) scans as either Aβ positive or negative. However, adjunct quantitative analysis is becoming more widely available, where regulatory approved software can currently generate metrics
A paleomagnetic and chronogical study has been performed on the Turinge gabbro-diabase formation and on a cross cutting basic dyke in central Sweden and on the Joulovaara gabbro intrusion in northern Sweden in the Fennoscandian Shield. U-Pb age of baddeleyite and 40Ar/39Ar ages of hornblende and biotite reveal a cooling history of the deep gabbro-diabase intrusion in Turinge. The cooling is sugges
Underground constructions for public traffic purposes are becoming increasingly important for urban areas in order to use the limited space more efficiently. Several electric resistivity tomography and seismic refraction tomography measurements were performed crossing a water passage near Stockholm during the pre-investigation phase of a tunnel building project. The objective was to determine the
This article addresses domestic civil society organisations (CSOs) and their multilevel strategies for gaining political influence in the European Union. Drawing on a theoretical framework identifying different 'routes' that CSOs can take in a multilevel system of EU governance, this article analyses which routes or combination of routes CSOs take and investigates what organisational factors can e
This article contributes to an understanding of how different institutional contexts produce similar outcomes as regards the employment of migrant workers in care work. It examines how the employment of migrant care workers in both the familial provision of care and the formal provision of care services for older people is shaped, first, by the marketisation of care and, second, by immigration con
BackgroundOut-of-hospital cardiac arrest (OHCA) survivors generally report good health-related quality of life, but physical aspects of health seem more affected than other domains. Limitations in physical function after surviving OHCA have received little attention.AimsTo describe physical function 6 months after OHCA and compare it with a group of ST elevation myocardial infarction (STEMI) contr
ObjectivesThe aim of this study was to investigate the potential correlation between muscle mass/muscle quality and risk of complications or recurrence in patients presenting with acute uncomplicated diverticulitis. It was also to study if low muscle mass/quality correlated to prolonged hospital stay.Materials and methodsThe study population comprised 501 patients admitted to Helsingborg Hospital
The increasing interest in seaweed as a food resource in Western societies raises concerns about associated potentially toxic elements (PTEs), including arsenic, cadmium, mercury, lead, and iodine. Hence, this study examined variation in PTEs by including samples of four different species (Ulva lactuca, Palmaria palmata, Alaria esculenta, and Saccharina latissima) from Ireland, as well as of a sin
