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BACKGROUND: There are important unmet clinical needs to develop cell enrichment technologies to enable unbiased label-free isolation of both single cell and clusters of circulating tumor cells (CTCs) manifesting heterogeneous lineage specificity. Here, we report a pilot study based on microfluidic acoustophoresis enrichment of CTCs using the CellSearch CTC assay as a reference modality.METHODS: Ac

The Circular Economy (CE) concept is widely promoted as a pathway to sustainability, yet its practical realization can appear to be challenging and unclear due to divergent definitions, interpretations and understanding about the implications and goals of a realized CE. Addressing this gap, this study develops the Circular Economy Loop Strategies (CELS) Framework, a synthesizing foundational model

This chapter reviews the historical development of the regulation of waste and chemicals in both international law and European Union (EU) law after the 1972 Stockholm Conference as well as some of the subsequent trends and themes. It also highlights the relevant interactions between EU and international law on these issues. The chapter ends with a discussion of how the regulatory frameworks relat

Populärvetenskaplig sammanfattning: Jordens klimat är ett aktuellt forskningsämne. För att komma fram till resultat som är globalt applicerbara bedrivs forskning för att öka förståelsen och kunskapen om återkopplingsmekanismer mellan klimat och vegetation på många platser runt om i värden och i olika klimatzoner. Sedan början av 1900-talet har det pågått forskningsstudier (av ekosystemprocesser) iThis report investigates the utilization of digital camera images (DCIs), sensitive in the visible part of the spectrum, for documentation of seasonal and inter-annual variations in snow cover and plant phenology. The DCIs used were transformed to orthographic images (ortho-image) from ordinary oblique DCIs taken between January 2001 and December 2003 at a sub- arctic mire (Stordalen) in northern

Biogenic ice-nucleating particles (INPs) can significantly impact mixed-phase clouds by enhancing precipitation and reducing albedo. As Arctic sea ice diminishes, the exposure of open ocean may increase aerosolization rates of marine bioaerosols and INPs. We investigated INP concentrations and microbial communities in ambient marine air, sea bulk water (SBW), and sea surface microlayer (SML) along

Like other Western legal systems, the Swedish legal system constructs objectivity as an unemotional state of being. We argue that the enactment of objectivity in situ relies on objectivity work including emotion management and empathy. Building on qualitative interviews and observations in Swedish district courts, we analyse courtroom interaction through a dramaturgical lens, highlighting tacit siLike other Western legal systems, the Swedish legal system constructs objectivity as an unemotional state of being. We argue that the enactment of objectivity in situ relies on objectivity work including emotion management and empathy. Building on qualitative interviews and observations in Swedish district courts, we analyse courtroom interaction through a dramaturgical lens, highlighting tacit si

Background: Low-cost particulate matter sensors have enabled new opportunities for exposure monitoring but require evaluation before application in epidemiological studies. This study assessed the performance of the SPS30 sensor integrated into the ARMIE portable monitoring sensor-node under controlled laboratory conditions. Methods: Sensors were co-located with two comparison instruments—the opti

The aim of this study was to establish traceable number concentration measurements of airborne particles beyond 10 μm in particle size. To this end, the primary standards for particle number concentration at the National Metrology Institutes of Switzerland and Japan were further developed to extend their measurement capabilities. Details on the upgraded setup are provided. An inter-comparison of t

Prostate cancer is the most diagnosed cancer in men. The diagnosis is confirmed by pathologists based on ocular inspection of prostate biopsies in order to classify them according to Gleason score. The main goal of this paper is to automate the classification using convolutional neural networks (CNNs). The introduction of CNNs has broadened the field of pattern recognition. It replaces the classic

The hematopoietic system is responsible for transporting oxygen and nutrients, fighting infections, and repairing tissue damage. Hematopoietic system dysfunction therefore causes a range of serious health consequences. Lifelong hematopoiesis is maintained by repopulating multipotent hematopoietic stem cells (HSCs) that replenish shorter-lived, mature blood cell types. A prokaryotic mechanism of im

The development of good writing skills is fundamental not only to publish scientific results, but also to have a deeper understanding of complex subjects. However reports from the Swedish Higher Education Authority from 2012-2015 suggest that engineering students at Lund University have unsatisfactory academic writing skills. Our paper investigates how students of the Faculty of Engineering at Lun

The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. However, its operative relevance in these cells remains elusive. We have over-expressed SKI to define its intrinsic role in hematopoiesis and myeloid neoplasms, which resulted in a robust competitive advantage upon transplantation, a complete dominance of the stem and progenitor compar

Rapport_Lönepremier för utbildning2.indd Lönepremier för utbildning – Utveckling under 2000-talet 2 Sammanfattning Denna rapport granskar lönepremien för högskoleutbildning perioden 2001–2020. Högskolepremien har minskat och är lägre nu än den var i början av 2000-talet. Framför allt är utvecklingen negativ inom privat och statlig sektor. Högskole- premien ökar något de senaste åren, men det är

https://www.saco.se/globalassets/bilder-video-och-dokument/sacos-rapporter/2022/rapport_lonepremier-for-utbildning_webb.pdf - 2026-06-28

Here we describe an in vitro co-culture system that can differentiate hematopoietic progenitor populations to all major hematopoietic lineages at clonal level. We present both a sensitive single-cell switch-culture system as well as a less laborious alternative barcoding protocol more convenient for larger cell numbers. Importantly, generation of all lineages from single long-term hematopoietic st

Sommaren 2018 var ett rekordvarmt år, och en markant ökning på solkurvor konstaterades av Trafikverket. Det finns flera orsaker till varför en solkurva uppstår, förutom den ökade temperaturen. När en solkurva bildas dras slutsatsen i många fall att anledningen endast är hög temperatur och vidare undersökningar utesluts direkt. Detta examensarbete består till stor del av en litteraturstudie som bThe summer of 2018 was a hot year, a significant increase of sun curves was observed by Trafikverket. There are several reasons why a sun curve occurs, in addition to the high temperature. When a sun curve is formed, the conclusion is drawn in many cases that the reason was heat and no further investigations are made. The project consists a literature study that explains the physical theory, fac

This thesis investigates the performance dynamics of serial acquirers in the Swedish market, specifically focusing on their ability to realize cost synergies over time. Through an empirical analysis of Swedish firms engaging in mergers and acquisitions (M&A) between 2010 and 2019, we aimed to determine whether serial acquirers exhibit improved synergy realization in subsequent acquisitions com