Filtyp
Climate change and connected environmental disruptions have a large negativeeffect on the health of humans and other species. Improved understanding ofknown links in the environment-disease nexus as well as knowledge gaps isessential to prepare for and mitigate this escalating threat. However, knowledgefragments are scattered across millions of scientific articles making informationsynthesis too c
Based on data searches and life-table analyses, we determined the long-term (remaining lifetime) and short-term (10- and 5-year) absolute risks of hip fracture after sustaining a Colles' or spine fracture and searched for potential gender-related differences. In aging men, Colles' fractures carry a higher absolute risk for hip fracture than spinal fractures in contrast to women. These findings sup
Aims Oral anticoagulation with vitamin K antagonists (VKAs) for stroke prevention in atrial fibrillation (AF) is effective but has significant limitations. AZD0837, a new oral anticoagulant, is a prodrug converted to a selective and reversible direct thrombin inhibitor (AR-H067637). We report from a Phase II randomized, dose-guiding study (NCT00684307) to assess safety, tolerability, pharmacokinet
Background: In todayʼs fast moving world, the communication of science and technology is playing an increasingly important role for the relation between science and the public. Both journalists and researchers have their own agenda when communicating as public interest, corporate science and the competition for funding increases. At the same time, the conditions on which stories about science can
Introduction TCP-25 gel is intended for use in treatment of wound infection and inflammation. Current local therapies for wounds have limited efficacy to prevent infections and there are no wound treatments available today that target the excessive inflammation that often hampers wound healing in both acute and chronic wounds. There is therefore a high medical need for new therapeutic alternatives
BACKGROUND: Tuberculosis remains a leading infectious cause of death in resource-limited settings. Effective treatment is the cornerstone of tuberculosis control, reducing mortality, recurrence and transmission. Supporting treatment adherence through facility-based observations of medication taking can be costly to providers and patients. Digital adherence technologies (DATs) may facilitate treatm
The toxicity of particulate matter (PM) is dependent on particle physical and chemical properties and is commonly studied using in vivo and in vitro approaches. PM to be used for in vivo and in vitro studies is often collected on filters and then extracted from the filter surface using a solvent. During extraction and further PM sample handling, particle properties change, but this is often neglec
Heparan sulfate proteoglycans consist of a small family of proteins decorated with one or more covalently attached heparan sulfate glycosaminoglycan chains. These chains have intricate structural patterns based on the position of sulfate groups and uronic acid epimers, which dictate their ability to engage a large repertoire of heparan sulfate-binding proteins, including extracellular matrix prote
Extracellular vesicles (EVs) are derived from the membrane of platelets and released in the circulation upon activation or injury. Analogous to the parent cell, platelet derived EVs play an important role in hemostasis and immune responses by transfer of bioactive cargo from the parent cells. Platelet activation and release of EVs increases in several pathological inflammatory diseases, such as se
Immunotherapy is revolutionizing cancer treatment, but success is limited to a fraction of patients. Tumor immunosurveillance and immunotherapy relies on presentation of tumor-associated antigens by conventional dendritic cells type 1 (cDC1). However, tumors develop mechanisms to avoid immune recognition such as downregulation of antigen presentation and exclusion of cDC1. We have previously demon
We present the use of a high capacity and high throughput acoustic trapping platform for phenotypic characterization and functional studies of extracellular vesicles (EVs) from pathogen activated platelets. Platelet rich plasma was stimulated with bacterial M1 protein isolated from S. Pyogenes, which is known to activate platelets. The subsequently released platelet EVs were isolated from 400 μL p
We study in detail the linear flow of particles on a graph with one vertex and k+1 infinite edges. This has a rich environment with many different emergent behaviours depending on the system parameters. The abrupt change in the behaviour of the system along a continuous change of the parameters manifests multiple phase transitions.We discuss the physical interpretation of the considered simple modWe study in detail the linear flow of particles on a graph with onevertex and k+1 infinite edges. This has a rich environment with many differentemergent behaviours depending on the system parameters. The abrupt changein the behaviour of the system along a continuous change of the parametersmanifests multiple phase transitions.We discuss the physical interpretation of the considered simple model ofpa
Stem cell lines that faithfully maintain the regional identity and developmental potency of progenitors in the human brain would create new opportunities in developmental neurobiology and provide a resource for generating specialized human neurons. However, to date, neural progenitor cultures derived from the human brain have either been short-lived or exhibit restricted, predominantly glial, diff
The aim of the present study is to develop a mathematical model for evaluating therapeutic response of combined treatment modalities. The study was performed in rats of the Fischer-344 strain with rat glioma N32 or N29 tumors implanted subcutaneously on the thigh of the hind leg. Pulsed electric fields, PEF, with 16 exponentially decaying pulses with a maximum electric field strength of 140 V/mm a
By employing seven semi-structured interviews with local judges and prosecutors in Kosovo, this study aims at examining how the European Union Rule of Law Mission (EULEX) has impacted the legal order in Kosovo and the practice of the judges and prosecutors. In addition, this study examines how the impacts of EULEX, and how the judges and prosecutors will be affected after the EULEX are withdrawn f
Ett regelverk i förändring. De särskilt inrättade reglerna för beskattning av delägare i fåmansföretag för kapitalvinst eller utdelning är unika på många sätt. De första tjugofem åren ändrades reglerna tjugotre gånger, nästan en gång per år. Främst beroende på bakomliggande svängningar i politiken. I fåmansföretagen finns det som huvudregel inget reellt tvåpartsförhållande då delägaren styr bolageThe specially made rules for taxation of partners in close companies regarding dividend are unique in many ways. During the first twenty-five years these rules changed twenty-three times, almost once a year. This occurrence was mainly due to underlining political balance between purposes. In these close companies there’s often no real two-party relationship as the partner oversees the company. Thi
