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Antimicrobial resistance has reached alarming levels in many countries, thus leading to a search for new classes of antibiotics, such as antimicrobial peptides whose activity is exerted by interacting specifically with the microorganism membrane. In this study, we investigate the molecular-level mechanism of action for Labaditin (Lo), a 10-amino acid residue cyclic peptide from Jatropha multifida
OBJECTIVE: Decision-making concerning the extent of the repair of acute type A aortic dissection (ATAAD) includes functional and anatomical assessment of the aortic valve. We hypothesized that bicuspid aortic valve (BAV) does not impact outcome after surgery for ATAAD. We therefore evaluated the outcome after ATAAD surgery in relation to the presence of BAV, acute aortic regurgitation (AR), and su
Polycythemia vera (PV) is a clonal stem cell disorder characterized by erythrocytosis and associated with burdensome symptoms, reduced quality of life, risk of thrombohemorrhagic complications, and risk of transformation to myelofibrosis and acute myeloid leukemia. The discovery of the JAK2 V617 mutation marked a significant milestone in understanding the pathophysiology of the disease and subsequ
We report the outcome in 32 patients operated on for advanced periacetabular metastatic destruction, where all but 2 had Harrington class III destruction. The patients were operated on using the Harrington reconstruction technique, where threaded pins and cement and a total hip replacement are used to reconstruct the acetabulum and ilium. The median survival was 11 (0-106+) months. 13 patients liv
The Harmonized Parabolic Synthesis methodology is a further development of the Parabolic Synthesis methodology for approximation of unary functions such as trigonometric functions, logarithms and the square root with moderate accuracy for ASIC implementation. These functions are extensively used in computer graphics, communication systems and many other application areas. For these high-speed appl
Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology. A characteristic feature of RA is the presence of anti-citrullinated protein antibodies (ACPA). Since ACPAs are highly specific for RA and are often present before the onset of RA symptoms, they have become valuable diagnostic and prognostic. As a result, several assays for detection of ACPAs exist, which vary in sensitivity a
We investigate the relation between crystal stacking faults in individual wurtzite InAs and GaAs nanowires and the intensity of the forbidden longitudinal optical (LO) phonon mode in the Raman spectra. Micro-Raman spectroscopy and transmission electron microscopy are combined on the same individual nanowires to evaluate the LO mode intensity as a function of the stacking fault density. A clear inc
Xyloside analogues with substitution of the endocyclic oxygen atom by sulfur or carbon were investigated as substrates for β-1,4-galactosyltransferase 7 (β4GalT7), a key enzyme in the biosynthesis of glycosaminoglycan chains. The analogues with an endocyclic sulfur atom proved to be excellent substrates for β4GalT7, and were galactosylated approximately fifteen times more efficiently than the corr
The objective of control flow obfuscation is to protect the program control flow from analysis. A technique called control flow flattening addresses static analysis by hiding edges between basic blocks in a program and introduces a dispatcher block that determines the execution order of the randomized blocks.In this paper we propose a novel flattening construction and lightweight dispatchers that
What explains variation in military spending? Conventional wisdom suggests that states arm because of either foreign threats or domestic political institutions. The literature treats these factors as distinct and separate (Nordhaus et. al. 2012, Fordham and Walker 2005, Goldsmith 2003). Less attention is given to how states with different internal constraints respond to similar circumstances. This
The environment of the Tibetan Plateau (TP) is regarded as one of the most sensitive ecosystems of the world. However, investigations on effects caused by global climate change or anthropogenic activities are rare due to its quite remote location. This thesis deals with various aspects of the carbon and water cycle within ecological and hydrological studies that can be assessed by measurements of
A new three-parameter (valency, ion size, and charge asymmetry) model, the asymmetric restricted primitive model (ARPM) of ionic liquids, has recently been proposed. Given that ionic liquids generally are composed of monovalent species, the ARPM effectively reduces to a two-parameter model. Monte Carlo (MC) simulations have demonstrated that the ARPM is able to reproduce key properties of room tem
This synopsis covers evidence for the effects of conservation interventions for native farmland wildlife. It is restricted to evidence captured on the website www.conservationevidence.com. It includes papers published in the journal Conservation Evidence, evidence summarized on our database and systematic reviews collated by the Collaboration for Environmental Evidence. It is the thrid volume in t
The arrival of the Digital Age added a new way to preserve memories of war and conflict. These developments beg deeper reflection on the role of cyberspace and how memories of conflict have become publicly and collectively owned, shared and mediated in the digital space. Cyberspace offers a context for the deposit of digital memorials for victims and casualties of war from any adversary in a confl
Diesel engines are by far the most common means of propulsion aboard ships. It is estimated that around half of their fuel energy consumption is dissipated as low-grade heat. The organic Rankine cycle technology is a well-established solution for the energy conversion of thermal power from biomass combustion, geothermal reservoirs, and waste heat from industrial processes. However, its economic fe
