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The use of daratumumab in combination with established regimens for the treatment of newly diagnosed multiple myeloma has recently been authorized by the European Medicines Agency based on results from three separate phase III randomized, active controlled, open-label studies that have confirmed enhanced efficacy and tolerability in both transplant-ineligible (MMY3008 and MMY3007) and transplant-e
Image Processing is rapidly expanding as a technique for object and defect analysis because of the high ease of its coupling to automation and IT solutions. Yet, issues with transferability of the measurement approaches and metrics currently used in mechanical systems often remain unsolved. Study reports on the developed approach for shape and defectiveness characterization by combining Delaunay t
This paper aims to identify and review new and unproven emergency department (ED) methods for improved evaluation in cases of suspected acute coronary syndrome (ACS). Systematic news coverage through PubMed from 2000 to 2006 identified papers on new methods for ED assessment of patients with suspected ACS. Articles found described decision support models, new ECG methods, new biomarkers and point-
This chapter provides a reassessment of the waste ‘crises’ in the so-called Land of Fires in Italy and highlights the contribution of local social mobilizations in advancing environmental justice and sustainability concerns. It is based on the long term collaboration between a social scientist and two activists, and it draws from a dialogue of academic and activist knowledge in the tradition of En
This paper deals with the estimation of the design force in self-tapping screws used as a reinforcement ofnotched cross laminated timber plates (CLT). With the reinforcement, apart from an increased load-carrying capacity, amore ductile behaviour of this detail can be achieved. An analytical model based on the Timoshenko Beam Theory wasdeveloped, enabling the estimation of the axial force in the r
Background: Patient adherence is defined as the extent to which a patient complies with medical or health advice. At present, there is a lack of reliable and valid measures specifically designed to measure adherence to internet-delivered behavioral interventions. Objective: The objective of this study was to develop and psychometrically evaluate a novel measure of adherence to guided internet-deli
The Sixth Assessment Report (AR6) of the Intergovernmental Panel on Climate Change represents the state of knowledge of anthropogenic disruption to the climate system, its diverse ecosystem and societal impacts, and the imperative for and challenges of mitigation and adaptation responses. It is foundational for global climate policymaking. This paper examines the place of tourism in AR6 and review
This study investigates the use of mobile data to understand patterns of population movements and disease transmission during the Covid-19 outbreak. It also focuses on understanding the implications of using this data for individual privacy. Using a mixed methods approach, we present 10 rich qualitative interviews and 412 survey responses from participants across the Nordics. Our novel results sho
Background & aims: Tissue transglutaminase autoantibodies (tTGA) are used as diagnostic markers of celiac disease. Different methods have been developed for the detection of tTGA of which enzyme-linked immunosorbent assays (ELISA), radiobinding assays (RBA) and electrochemiluminescence (ECL) assays are the most commonly used. Here we aimed to evaluate a novel antibody detection by agglutinatio
It has been proposed that the relatively low duty cycle of the European Spallation Source (ESS) linac allows acceleration of additional mathbfH^- ion pulses interleaved with the baseline proton pulses, representing a unique opportunity to construct a neutrino super beam (ESSnuSB) facility of unparalleled luminosity. Coupled with a distant Cherenkov detector, it is believed that evidence of CP viol
BACKGROUND: Amyloid-β (Aβ) is a normal product of neuronal activity, including that of the aggregation-prone Aβ42 variant that is thought to cause Alzheimer's disease (AD). Much knowledge about AD comes from studies of transgenic rodents expressing mutated human amyloid-β protein precursor (AβPP) to increase Aβ production or the Aβ42/40 ratio. Yet, little is known about the normal expression of Aβ
Mycobacterial infections, including tuberculosis, are a major health problem globally. Prevention and treatments of tuberculosis are challenging due to the poor efficacy of the current vaccine and the emergence of drug-resistant strains. Therefore, it is critical to increase our basic understanding of mycobacterial virulence strategies as well as the host immune response during infection in the co
The role of multiple groups of primary biological aerosol particles (PBAPs) as ice nucleating particles (INPs), and of ice formation processes such as time-dependent freezing of various INPs, and various secondary ice production(SIP) mechanisms in overall ice concentration has been evaluated in a range of cloud systems by simulating them numerically with the state-of-the-art ‘Aerosol-Cloud’ (AC) m
Purpose The paper proposes a framework for the successful deployment of Industry 4.0 (I4.0) principles in the aerospace industry, based on identified success factors. The paper challenges the perception of I4.0 being aligned with de-skilling and personnel reduction and instead promotes a route to successful deployment centred on upskilling and retaining personnel for future role requirements. Desi
There is a lack of knowledge among food manufacturers about adopting the Internet of Things (IoT)-based water monitoring system and its ability to support water minimisation activities. It is therefore necessary to investigate the applicability of IoT-based real-time water monitoring systems in a real food manufacturing environment to pursue water-saving opportunities accordingly. This article aim
During the first year of NASA's Mars 2020 mission, Perseverance rover has investigated the dark crater floor unit of Jezero crater and four samples of this unit have been collected. The focus of this paper is to assess the potential of these samples to calibrate the crater-based Martian chronology. We first review the previous estimation of crater-based model age of this unit. Then, we investigate
Strategy is considered one of the most central concepts in public relationsresearch and practice. However, public relations strategizing, i.e., the doingof strategy, remains a black-box concept in public relations and wouldbenefit from additional approaches to theorizing strategy. This conceptualarticle draws upon strategy-as-practice, practice theory, and the existentialistnotion of human modes o
Weighted blankets are a non-pharmacological intervention for treating sleep and anxiety problems in children with attention-deficit/hyperactivity disorder. However, research on the efficacy of weighted blankets is sparse. The aim of this randomized controlled trial with a crossover design (4 + 4 weeks) was to evaluate the efficacy of weighted blankets on sleep among children with attention-deficit
