Filtyp
Background. In metastatic colorectal cancer, mutation testing for KRAS exon 2 is widely implemented to select patients with wild-type tumors for treatment with the monocloncal anti-EGFR antibodies cetuximab and panitumumab. The added predictive value of additional biomarkers in the RAS-RAF-MAPK and PI3K-AKT-mTOR pathways in colorectal cancer is uncertain, which led us to systematically review the
The southern Peruvian coastal desert around Palpa, southern Peru (14.5 degrees S) is currently characterized by hyper-arid conditions. However, the presence of two species of molluscs (Scutalus, Pupoides) and desert-loess deposits indicates the past development of semi-desert and grassland ecosystems caused by a displacement of the eastern desert margin due to hydrological changes. Radiocarbon dat
Very high levels of ambient particulate matter (PM) are frequently encountered in the north of Italy and air quality limits are regularly exceeded. To obtain quantitative information on the pollution sources and to gain understanding of the dynamics of pollution episodes in this populated area PM10 and/or PM2.5 samples were collected daily at nine urban to regional sites distributed over the centr
The main goal of this thesis is to determine to what degree can there be observed indications for an overvaluation of Internet companies, which in turn may lead to the next asset price bubble in the Internet industry. By conducting an ex-ante analysis, the current study sets out to add additional knowledge in regards to whether and how well the emergence of a bubble can be determined in advance. T
Uppsatsen behandlar Oscar Wildes The Picture of Dorian Gray ur ett queerfeministiskt perspektiv, med utgångspunkt i Eve Kosofsky Sedgwicks teorier om framför allt erotiska trianglar och homosociala relationer män emellan. Uppsatsen behandlar även hur "maskulinitet" och "femininitet" representeras i romanen och hur dessa representationer påverkar de tre huvudkaraktärernas hierar
The purpose of this study is twofold. Firstly, it aims to contribute to research by creating an understanding of how partners are selected in practice by an open innovation community. Secondly, it aims to contribute to research by building on the theories of causation and effectuation, as well as bricolage - a novel approach to partnership selection. We took an interpretive epistemological stance,
Background: SCOR is a worldwide accepted and renowned process reference model that is developed and endorsed by the non-profit organization Supply Chain Council. It’s a cross-industry diagnostic tool for supply chain management. Consafe Logistics wanted to know if a performance measurement system for warehouse activities could be developed based on the SCOR model, and how it could be applied in th
The MENA (Middle East and North Africa) region enjoys a high availability of clean renewable energy sources, especially solar. In recent years, several countries within the region have introduced policy instruments to encourage the deployment of distributed solar photovoltaic (PV). This thesis reviews and evaluates policy instruments adopted in Egypt, Palestine and Tunisia. The experiences from th
Purpose: The purpose of the thesis is to critically review different pricing strategies with a special focus on Revenue Management and discuss the possibilities and challenges for hotels when optimising their profitability. Methodology: We have conducted three case studies on hotels located in the Öresund region. The studies were done with a qualitative research approach. The respondents are all w
Motivated by growing considerations of the scale, severity, and risks associated with human exposure to indoor particulate matter, this work reviewed existing literature to: (i) identify state-of-the-art experimental techniques used for personal exposure assessment; (ii) compare exposure levels reported for domestic/school settings in different countries (excluding exposure to environmental tobacc
Efforts are made in radiographic examinations to obtain the best image quality with the lowest possible absorbed dose to the patient. In dental radiography, the absorbed dose to patients is very low, but exposures are relatively frequent. It has been suggested that frequent low-dose exposures can pose a risk for development of future cancer. It has previously been reported that there was no signif
A search is performed for collimated muon pairs displaced from the primary vertex produced in the decay of long-lived neutral particles in proton-proton collisions at root s = 7 TeV centre-of-mass energy, with the ATLAS detector at the LHC. In a 1.9 fb(-1) event sample collected during 2011, the observed data are consistent with the Standard Model background expectations. Limits on the product of
This thesis discusses the recent hot topic in the intersection of IP law and competition law; “pay-for-delay” agreements in the pharmaceutical industry. Such agreements arise in patent disputes where originator manufacturers (‘Originators’) claim patent infringement by the generic manufactures (‘Generics’). However, patent infringing defendants end up paying the plaintiff large sums of money, acco
Abstract This essay will examine if there is a possibility that the Millennium Development Goal number 3 (MDG 3) can be achieved by year 2015 in Bangladesh. Therefore, an examination will be performed of the report The Millennium Development Goals, Bangladesh Progress Report 2011. Focus will be on MDG 3 which aims on promoting gender equality and women’s empowerment for instance in Bangladesh. In
This study presents an integrated simulation framework that combines agent-based transport modeling with probabilistic load-flow analysis to quantify power system loading of long-haul heavy-duty electrification. The approach is applied to a case study considering fully electrified road freight in the Skåne region in Sweden, using high-resolution transport demand data and the actual power grid mode
Computational models play an increasingly vital role in scientific research by enabling the numerical simulation of complex processes. Such models are also fundamental in geosciences. For instance, they offer critical insights into the impacts of global change on the Earth system today and in the future. Beyond their value as research tools, models are also software products and should therefore a
This study describes an aggregate relationship between exchange rate risk and foreign direct investments. The relationship is conducted by panel data estimations, with variables derived from the OLI-framework and prior research. Sample data consists of 36 countries for the time series 1991-2009. Estimations are controlled for country specific variations by using fixed effects, regional dummy varia
