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Significance Our results demonstrate the existence of early cellular pathways and network alterations in oligodendrocytes in the alpha-synucleinopathies Parkinson's disease and multiple system atrophy. They further reveal the involvement of an immune component triggered by alpha-synuclein protein, as well as a connection between (epi)genetic changes and immune reactivity in multiple system atrophy
Introduction Breathlessness is debilitating and increases in prevalence with age, with people progressively reducing their everyday activities to ‘self-manage’ it. This study aimed to evaluate the impact of breathlessness on function in terms of activities that have been reduced or ceased (‘compromised’) in older men.Methods A cross-sectional postal survey of Swedish 73-year-old man in the VAScula
Intraosseous (IO) access is normally reserved for emergencies and critical care conditions when venous cannulation is not possible. Nonetheless, we present a case of IO insertion to a 56-year-old man, tetraplegic for many years due to progressive spinal muscular atrophy and with refractory suffering. The IO access was used for palliative sedation with propofol in a home care setting. The patient d
In this paper we report the linear and non-linear optical properties of metallic nano-clusters in α-Al 2O 3 fabricated by ion implantation (from 2 to 8×10 16 ions/cm 2). Thereafter, the samples were annealed at temperatures from 600 to 1100°C in oxidising, reducing atmospheres. Once spherical nano-particles were synthesized, the samples were further irradiated with Si +++ with different energies a
Objectives Nocturnal hypoxia in obstructive sleep apnoea (OSA) is a potential risk factor for cancer. We aimed to investigate the association between OSA measures and cancer prevalence in a large national patient cohort. Design Cross-sectional study. Settings 44 sleep centres in Sweden. Participants 62 811 patients from the Swedish registry for positive airway pressure (PAP) treatment in OSA, link
This paper discusses the relationship between the Sustainable Development Goals (SDGs) and the long-standing human rights system of the United Nations. Thematically, these two modes of global governance strongly overlap. Several SDGs are in line with human rights obligations. At the same time, the SDGs and human rights are based on divergent logics and constructed very differently. After capturing
Sustainable development goals assume that basic notions such as health, life and water can be universally and easily expressed and understood across diverse communities and stakeholders. Yet there is growing evidence pointing to considerable semantic diversity in how humans represent the world in language. In this paper I discuss such semantic diversity in the context of key notions of sustainabil
The Paris Agreement, adopted in 2015, paved the way for a new hybrid global climate governance architecture with both bottom-up and top-down elements. While governments can choose individual climate goals and actions, a global stocktake and a ratcheting-up mechanism have been put in place with the overall aim to ensure that collective efforts will prevent increasing adverse impacts of climate chan
The goal of this study is to identify the perspectives that development NGOs attribute to organisational social media, and furthermore elaborate on an appropriate categorisation of these perspectives for social media use by development NGOs. How social media is used in the area of development, where the use goes far beyond the private sector purpose of publicity and converting a sale, is a key iss
ObjectivesBeing met with empathy increases information sharing, treatment coherence, and helps patients to recover faster. However, we do not know how the content of the conversation about disease progression, new treatments, or other issues concerning serious illness affects patients' perceptions of the physician's empathy, and thus, the quality of the conversation. This study aimed to test the h
Globally we are facing a complex web of grand challenges that are impacting the lived environment, our development pathways, and wider quality of life. Urban environments serve as a key context around which these grand challenges are not only experienced while also providing multiple opportunities to reduce environmental impacts and resource consumption; improve health outcomes; eradicate poverty;
In this 2 hour workshop the experiences of the geographic data domain will be shared with the open data research & education community to promote and strengthen active innovative learning and teaching in both worlds. The domain of geographic data can be considered as one of the front running in open data. Over the past two decades, many geographic datasets in Europe became available as open da
Lung cancer (LC) generally lacks unique core symptoms or signs. However, there are a multitude of bodily sensations that are often non-specific, not easily understood, and many times initially not recognized as indicative of LC by the affected person, which often leads to late diagnosis. In this international qualitative study, we inductively analyzed retrospective accounts of 61 people diagnosed
Ett ekologisk, ekonomiskt och socialt hållbart nyttjande av jordens resurser är en viktig förutsättning för en hållbar samhällsutveckling och inte minst för vår förmåga att tackla och anpassa oss till aktuella och framtida utmaningar, såsom klimatförändringar eller pandemier. En av de stora frågorna kopplat till detta är markanvändningen: Hur vi ska använda våra begränsade markresurser, så att vi
Introduction: Patients with midgut neuroendocrine tumours (NETs) suffer from decreased health-related quality of life (HRQoL), in large part due to bowel symptoms. However, it is unknown which bowel symptoms affect HRQoL the most. An enhanced understanding of this is essential to better focus treatment on this aspect of the disease. This study aimed to determine which bowel symptoms affect HRQoL t
Doktorsavhandlingen ger inblick i en betydelsefull konsekrerande beslutsprocess inom det svenska konstfältet under perioden 1885–1920. Den analyserar de sociala strukturer som bar fram Nationalmuseums inköpsnämnds och museinämnds årliga beslutsförslag till Kungl. Maj:t om vilka oljemålningar, skapade av vid tiden levande svenska konstnärer, som skulle inlemmas i samlingarna och vilka som skulle exThis dissertation examines the Swedish National Museum of Fine Arts (Nationalmuseum) as a consecrating institution of fine art, between 1885 and 1920. A time influenced by major events such as the First World War, Sweden’s industrial revolution and the advent of universal suffrage. During this period, the production and consumption of the Arts was characterised by rivalry between three fractions,
This paper describes a knowledge integration framework for robotics, whose goal is to represent, store, adapt, and distribute knowledge across engineering platforms. The architecture abstracts the components as data sources, where data are available in the AutomationML data exchange format. AutomationML is an on-going standard initiative that aims at unifying data representation and APIs used by e
This chapter complements the analysis in Chapter 2 by a policy-oriented inquiry of how different degrees of fragmentation of governance architectures are likely to affect the environmental effectiveness of policies. Our study relates here to an area of widespread contestation in academic and policy writing. It is often maintained, as we describe further below, that a more integrated climate govern
There is an urgent need to start generating energy within cities in order to pave the way for a more sustainable and resilient society. Renewable energy by means of active solar energy systems (solar thermal, ST and/or photovoltaics, PV) can be generated using roofs and facades of buildings. In this study, the annual solar energy potential of typical Swedish city blocks was analysed in order to de
