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Much is known about the geoepidemiology of defined autoimmune diseases (AD); however, there is currently limited data regarding the prevalence of autoantibodies among healthy populations of different geographical areas. The aim of this study was to evaluate a large profile of autoantibodies in healthy adults from distinct global regions as well as the prevalence of anti-infectious agents antibodie
Cathepsin E (CTSE), an aspartic proteinase, is differentially expressed in the metaplasia-dysplasia-neoplasia sequence of gastric and colon cancer. We evaluated CTSE in Barrett's esophagus (BE) and cancer because increased CTSE levels are linked to improved survival in several cancers, and other cathepsins are up-regulated in BE and esophageal adenocarcinoma (EAC). A total of 273 pretreatment tiss
Objectives High-risk human papillomavirus (hrHPV) is the primary cause of cervical cancer. As Chlamydia trachomatis is also linked to cervical cancer, its role as a potential co-factor in the development of cervical intraepithelial neoplasia (CIN) grade 2 or higher was examined. Methods The placebo arms of two large, multinational, clinical trials of an HPV6/11/16/18 vaccine were combined. A total
BACKGROUND: Insulin resistance was found in some but not in all previous studies of non-diabetic first degree relatives of Type 2 diabetic patients. Small study groups, ethnic differences and/or non-optimal techniques may explain the conflicting results. AIM: To study the impact of a family history of Type 2 diabetes on insulin action in a large group of non-diabetic Europeans using the 'gold stan
OBJECTIVE— The purpose of this study was to assess the role of household conditions for the progression to diabetes in women with impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS— A total of 461 women, aged 50–64 years, with IGT defined by an oral glucose tolerance test, had baseline advice on physical exercise, diet, smoking, and alcohol habits. Physical examination, blood tests, an
Background Job strain (high demands and low decision latitude) and the DID genotype of an I/D polymorphism in the adrenergic alpha(2B)-receptor have been associated with hypertension, respectively. We hypothesized that the I/D polymorphism interacts with external stress, such as job strain, in the development of hypertension. Methods A sample of 3045 employed men and women from the population coho
Polyiodides and binary metal iodide-iodine compounds have been prepared and investigated by means of X-ray diffraction, EXAFS, far-IR, Raman, UV-vis and NMR spectroscopy and quantum chemical calculations. (Et3S)[AuI4].2I2 and (Me3S)[Cd2I6]1/2.3I2 were synthesised through the reaction between the room temperature melt of trialkylsulfonium polyiodides and the corresponding metal iodides. The structu
Reviewing the historical legacy of colonialism and slavery on attitudes about race, gender and citizenship within the United States, this thesis attempts to illuminate three principle archetypes within development discourse: the Brute, the Victim and the Authority. Each of these three discursive threads, deriving from unique historical processes, provides an opposing Other against which US citizen
Försäljning av alkohol har varit reglerat under mycket lång tid i Sverige. Den nuvarande regleringen kan spåra sina rötter till 1800- talets mitt och även om reglering förändrats över tiden så är försäljning av alkohol fortfarande starkt reglerad. Alkoholagens syfte är att begränsa alkoholens skadeverkningar. En konsekvens av alkoholagens syfte är att det ställs hög krav på den som vill bedriva seThe sale of alcohol has been regulated for a very long time in Sweden and the origin of the current regulations can be traced to the middle of 1900 century. The nature of these regulations have changed a great deal overtime but the sale of alcohol remains heavily regulated. The main purpose of the Swedish alcohol law “alkohollagen” is to limit the damages caused by alcohol use and as a consequence
Purpose: The purpose of this thesis is to describe different types of relations between ERP vendors and consultants and analyze how these relationships affect the role of the consultant in ERP implementation. Methodology: Primarily, a qualitative method has been undertaken in the collection of empirical data. This was performed through multiple case studies with six case companies, which provide
Extreme events on the financial market has become an important and high-attention topic. Several well know historical market crashes has taken investors and academics with surprise and there is an urge to understand these anomalous events. The Johansen-Ledoit-Sornette model aims to describe speculative bubbles and anti bubbles on financial markets, often ending in endogenous crashes or rebounds. I
Tying arrangements have been controversial and regarded with suspicion for a long time both within the EC competition law and within the US antitrust law. Tying is a vertical restraint and can be described as an obligation to accept the purchase of an unwanted or unnecessary product or service in order to be able to purchase a wanted product or service. A tying arrangement presupposes an element o
Naive male and female silver Y moths, Autographa gamma (Lepidoptera: Noctuidae), were attracted in a flight tunnel assay to potted creeping thistle, Cirsium arvense (Asteraceae), butterfly-orchid, Platanthera bifolia (Orchidaceae), soapwort, Saponaria officinalis (Caryophyllaceae), greater knapweed, Centaurea scabiosa (Asteraceae), red clover, Trifolium pratense (Fabaceae), and catnip, Nepeta faas
It is recommended that the hip joints be flexed to 90 degrees during dual-energy X-ray absorptiometry scanning of the lumbar spine in the anteroposterior projection; however, some patients are unable to maintain this position because of the presence of degenerative changes in lower limb joints. This study examines the effect of a lesser degree of hip flexion on the lumbar spine bone mineral densit
Here we studied the effects of glial cell line-derived neurotrophic factor (GDNF) in a rat model that represents the symptomatic stages of Parkinson's disease. GDNF was infused starting 2 weeks after an intrastriatal 6-hydroxydopamine (6-OHDA) lesion in order to halt the ongoing degeneration of the nigrostriatal dopaminergic neurons. GDNF or vehicle was infused in the striatum or the lateral ventr
OBJECTIVE: To assess postural performance in patients with dizziness of suspected cervical origin in whom extracervical causes had been excluded, and to assess the effects of physiotherapy on postural performance and subjective complaints of neck pain and dizziness. DESIGN: Prospective, randomized, controlled trial. SETTING: Primary care centers and a tertiary referral center. PATIENTS AND SUBJECT
Soil microorganisms, the central drivers of terrestrial Antarctic ecosystems, are being confronted with increasing temperatures as parts of the continent experience considerable warming. Here we determined short-term temperature dependencies of Antarctic soil bacterial community growth rates, using the leucine incorporation technique, in order to predict future changes in temperature sensitivity o
