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This study develops a strategic framework to guide the adoption of Industry 4.0 technologies across various business sectors. Using a mixed-methods approach, the research combines an extensive literature review with empirical investigations, including case studies and surveys with industry practitioners. The framework integrates advanced digital technologies, such as artificial intelligence and im
The maker movement has reached the optics labs, empowering researchers to create and modify microscope designs and imaging accessories. 3D printing has a disruptive impact on the field, improving accessibility to fabrication technologies in additive manufacturing. This approach is particularly useful for rapid, low-cost prototyping, allowing unprecedented levels of productivity and accessibility.
We explore whether SAM2, a vision foundation model, can be used for accurate localization of eye image features that are used in lab-based eye tracking: corneal reflections (CRs), the pupil, and the iris. We prompted SAM2 via a typical hand annotation process that consisted of clicking on the pupil, CR, iris and sclera for only one image per participant. SAM2 was found to support better spatial pr
This book provides a highly accessible and user-friendly overview of the essential concepts and terms related to the current global endeavour to implement the Sustainable Development Goals.With the first decade of the 15-year timespan of the 2030 Agenda now past, the SDGs show limited progress and several goals are even regressing. It is imperative that SDG implementation is accelerated until 2030
Synthesis of molecularly imprinted polymer microspheres using precipitation polymerization was first reported in 1999 in Lund. The synthetic approach attracted great interest for molecular imprinters worldwide due to its simplicity. Following the initial demonstration of feasibility for material synthesis, imprinted polymer microspheres were found to exhibit good colloidal stability qualifying for
RNA medicines represent a paradigm shift in treatment and prevention of critical diseases of global significance, e.g., infectious diseases. The highly successful messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were developed at record speed during the coronavirus disease 2019 pandemic. A consequence of this is exceptionally shortened vaccine deve
Quality requirements are critical for successful software engineering, with maintainability being a key internal quality. Despite significant attention in software metrics research, maintainability has attracted surprisingly little focus in the Requirements Engineering (RE) community. This position paper proposes a synergistic approach, combining code-oriented research with RE expertise, to create
As one of the most critical components of the vanadium redox flow battery (VRFB), the ion exchange membrane directly influences the battery efficiency and cycle life. Herein, poly(isatin triphenyl) (PIT) containing a lactam structure and devoid of ether bonds is synthesized from isatin and p-terphenyl under superacid catalysis. To achieve the ion transport and investigate the impact of side chain
We report two crystal structures of the PARP domain of human tankyrase-2 (TNKS2). Tankyrases are involved in fundamental cellular processes such as telomere homeostasis and Wnt signaling. The complex of TNKS2 with the potent inhibitor XAV939 provides insights into the molecular basis of the strong interaction and suggests routes for further development of tankyrase inhibitors.
Profilins are key regulators of actin dynamics. They sequester actin monomers, forming a pool for rapid polymer formation stimulated by proteins such as formins. Apicomplexan parasites utilize a highly specialized microfilament system for motility and host cell invasion. Their genomes encode only a small number of divergent actin regulators. We present the first crystal structure of an apicomplexa
Shadi Hamid proposes “democratic minimalism” as a system and means of governing and rotating power with no prejudice to substantive ideological outcomes. Democratic minimalism is meant to decouple the question of actualizing an ideal society, even a liberal one that provides maximum freedom for the maximum groups of people, from the mechanism of transferring power between groups with opposing beli
The Cretaceous period is the time of the first appearance of the diatoms in the fossil record. These fossils give us direct evidence of the age and early evolution of the diatom lineage. The fossil record, however, is incomplete and therefore often extrapolated through time-calibrated phylogenies. These two approaches offer different perspectives on the early evolution of diatoms, which is still p
The purification of crude (60.89% pure) paclitaxel was developed for high purity and yield. Several solvent systems, including methanol (MeOH), acetone, tetrahydrofurane, n-hexane, and water, were evaluated for precipitation efficiency. The best results were obtained using a mixture of MeOH and water, which was very effective at removing polar impurities, yielding a precipitate with 90.87% purity.
The linear inverse problem associated with the standard model for hyperspectral image recovery from CASSI measurements is considered. This is formulated as the minimization of an objective function which is the sum of a total variation regularizer and a least squares loss function. Standard first-order iterative minimization algorithms, such as ISTA, FISTA and TwIST, require as input the value of
Modeling metalloproteins often requires classical molecular dynamics (MD) simulations in order to capture their relevant motions, which in turn necessitates reliable descriptions of the metal centers involved. One of the most successful approaches to date is provided by the "cationic dummy model", where the positive charge of the metal ion is transferred toward dummy particles that are bonded to t
This work investigates the design of beampatterns for frequency diverse arrays-multiple-input multiple-output (FDA-MIMO) in the range-angle plane, in order to improve the approximation of a desired beampattern. Recognizing that the energy radiated by the array cannot be locked at a fixed range and angle, the beampattern is designed for the equivalent beampattern at the receiving end, differing fro
We present the electrical and mechanical design of a button beam position monitor (BPM) recently developed and installed in the UVX electron storage ring at the Brazilian Synchrotron Light Laboratory (LNLS). The first characterization results will also be presented. This development started when we observed strong correlation between false stripline BPM readings and the external temperature of thi
