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Background: Neutralizing antibodies provide markers for vaccine-induced protective immunity in many viral infections. By analogy, HIV-1 neutralizing antibodies induced by immunization may well predict vaccine effectiveness. Assessment of neutralizing antibodies is therefore of primary importance, but is hampered by the fact that we do not know which assay(s) can provide measures of protective immu
Abstract in UndeterminedThis paper addresses the failure of activation programmes to achieve a rapid return to work when they are directed towards the long-term ill. The empirical basis for the paper is an analysis of the outcomes for 691 individuals in Sweden chosen for a re-activation policy programme to shorten their sick leave and increase their chances of returning to work. The outcome at the
The ambition to be recognized as a 'World City' or 'Global City' is rapidly increasing not the least among cities in the global south such as Hyderabad in India and Johannesburg in South Africa. While such a status seems promising for attracting foreign capital and for expanding the economic potential of urban areas, it may have adverse impacts on the hinterland and contribute to growing urban ine
Voorhees et al. (Reports, 5 November 2010, p. 835) determined the structure of elongation factor Tu (EF-Tu) and aminoacyl-transfer RNA bound to the ribosome with a guanosine triphosphate (GTP) analog. However, their identification of histidine-84 of EF-Tu as deprotonating the catalytic water molecule is problematic in relation to their atomic structure; the terminal phosphate of GTP is more likely
Objective:To assess the importance of MAPT variant p.A152T in the risk of synucleinopathies. Methods:In this case-control study, we screened a large global series of patients and controls, and assessed associations between p.A152T and disease risk. We included 3,229 patients with clinical Parkinson disease (PD), 442 with clinical dementia with Lewy bodies (DLB), 181 with multiple system atrophy (M
In a circular accelerator the closed orbit can be viewed as the mean position of particles in a beam. The closed orbit is perturbed by machine errors and can be manipulated by dedicated corrector magnets. This thesis introduces a linear algebra framework for closed orbit perturbation and correction, its implementation as a Python package and its use for three studies in HL--LHC: orbit corrector bu
To develop treatments for currently uncurable neurological disorders, more knowledge is needed of the involved neural circuits and changes in gene expression. The padlock probe technique, in which linear DNA probes are circularized and amplified when hybridized to their cDNA target sequence, has previously been used for both multiplexed gene detection and neuronal projection mapping in brain tissu
This study arises from an existential concern that there is an obliviousness in academia with regards to the recent eruption of the transhumanist movement–an ideological force imbued with potentially calamitous socioecological consequences. With the support from recent claims that the transhumanist ideology exerts powerful influence on Western politics, this study seeks to investigate how the tran
Due to the changing nature of employment, contemporary early career employees place more value on work-life balance than any other generation before them. Our purpose is to provide a contextual overview that identifies and illuminates some of the defining characteristics of the early career employees employed in the banking sector. The integration of the boundary and motivation theory enable us to
The problem of outdated large-scale housing estates has been prevalent in many cities, resulting in unbalanced social issues, uncomfortable living conditions, and a lack of response to climate change. The research focuses on the Almgården area in Malmo, Sweden, and aims to address these challenges by proposing a sustainable design solution that can improve the quality of life for residents while r
The purpose of this report is to implement and compare the two Basel III standard methods on how to calculate the capital requirement for finan- cial institutions, related to counterparty credit risk. The models being the Standardized Approach for Counterparty Credit Risk (SA-CCR) and the Internal Model Method (IMM). The SA-CCR model is a simpler and more standardized model with prescribed methods
Co-simulation is widely used in industry for the simulation of multi-domain linear-time-invariant systems. However, as a result of the not continuous communication between our coupling variables, simulation results end up being unstable and inaccurate. Among the different strategies that have been developed in the recent years to control co-simulation drawbacks, the aim of this thesis is to unders
This thesis creates multiple indices to score and rank developing countries with regard to their suitability for engaging in debt-for-climate swaps, and thus identify the most suitable country candidates. The origin of debt-for-climate swaps lies in the 1980s, and after a period of diminished use and attention they have become a topic of discussion again, especially in the last two years. Desp
Payment and bonus schemes based on seed quality used by the Swedish agriculture cooperative Lantmännen is evaluated. Results from a farm and region/time fixed effect model show that the linear payment scheme for pulses (peas and beans) has approximately 15 percentage points lower quality compared to that used for grains when a common quality measure constructed for this research is used. Germinati
Sammanfattning Digitala övervakningskameror har tidigare använts inom fenologisk forskning för att kunna mäta grönskan i trädkronor. Man har under en längre tid kunnat koppla lövträdets årscykel till klimatförändringar och på så sätt haft ett starkt incitament att studera sambandet. I denna uppsats utforskas möjligheten att applicera metoden med digitalkameror på ett nyligen kalhugget område för aAbstract The use of inexpensive digital cameras in phenological research has been acclaimed since results in previous research have shown that they are reliable and precise in measuring greenness of vegetation. The work of this thesis aims to broaden the applicability by studying how well the method performs when measuring the regrowth of a clear-cut area. This is needed to complement existing res
The advantages with infrared heating and the fact that the technology has become significantly more inexpensive opens up a bigger interest to develop products using infrared heaters further. What will the future kitchen look like? How can infrared technology develop and create more conventional and intellectual products processing our food? By pushing the limits of the technology today the main
This thesis investigates the stock return and its variance around seasoned equity offering announcements for Swedish companies listed on the OMX Large cap, Mid cap and Small cap exchanges. The analysis is made on a full sample containing 52 SEOs, as well as two sub-samples containing underwritten and non-underwritten SEOs. The framework for the event study is OLS regressions based on the CAPM-mode
