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Human antibodies generated in vitro may be highly valuable for diagnostic and therapeutic purposes. For a long time most human antibodies produced in vitro have been of the IgM isotype with rather low affinities. In this thesis a method for production of IgG switched antigen-specific human antibodies is presented. This is a two step protocol, in which the first step is a selection procedure of don

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We deal with a natural integer-linear programming formulation of the routing and spectrum allocation (RSA) problem in elastic optical networks. We focus on strengthening the formulation with valid inequalities (cuts). For this purpose we apply clique inequalities that proved to be useful in other applications of this kind. We develop and combine a clique cut generation procedure with a column gene

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Popular Abstract in Swedish Cancer i tjock- och ändtarmen är idag den tredje vanligaste formen av till döden ledande cancer i världen. Den är vanligast i de högindustrialise-rade delarna av världen: Europa, Nord-Amerika och Australien. Prognosen för den enskilde patienten är helt beroende på cancerns utbredning vid diagnostillfället. Cancerns utbredning bedöms idag enligt olika indelningsprincipeAim of the study Today´s methods for the staging of rectal carcinoma: ultrasonography with transrectal probe, CT, MRI or MRI with a rectal coil, all have limitations. The aim was therefore to develop a new, double-contrast MRI method for evaluation of rectal carcinoma. The idea was that a rectally applied contrast medium causing distension and signal void of the rectal lumen and an intravenous inj

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Critical infrastructures provide society with services that are essential for its functioning and extensive disruptions of these give rise to large societal consequences. Vulnerability analysis gives important decision information concerning improving their ability to withstand strains. To analyze vulnerabilities in infrastructures models for estimating consequences due to failures are needed. Con

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This Bachelor thesis aims to analyze and clarify the situation of the irregular migrants in United Kingdom, whether it´s changing when applying UK:s own migrant legislation; The UK Immigration Act 2014, compared to EU:s migration policy and legislation. Based on Hannah Arendts theory on the irregular migrants loses their right to have rights, when migrating from their original country. These peopl

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Parkinson’s disease (PD) is a highly heterogenous disorder characterized by bradykinesia, rigidity, rest tremor and non-motor symptoms like cognitive impairment, anosmia, and sleep disturbance. The underlying pathological hallmarks of PD are the degeneration of dopaminergic pigmented neurons in the substantia nigra pars compacta, neuroinflammation and, alpha synuclein inclusions accumulating into

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This master thesis has investigated if flow cytometry can be used to monitor bathing water quality on the beaches in Southern Sweden. The current method for monitoring the bathing water quality takes 3 days to get results about the concentrations of fecal indicator bacteria, E.coli and intestinal enterococci, and to get answers if the water is usable or unusable for swimming. These bacteria serve

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Inflammatory bowel disease (IBD) is a global disease affecting more than 3.5 million people in the world, resulting in a high burden to societies. More research on IBD is definitely in need to prevent the disease and treat IBD patients. The intestinal epithelial barriers of IBD patients are weakened due to the inflammation, thereby, enteric microbes in the gut may translocate to the circulating sy

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This thesis explores the correlation between national role conceptions, national identities and sensemaking processes among South Korean and Swedish policy influencers during the Sunshine Policy years of 1998-2003. The study relies on in depth semi structured interviews with 10 policy influencers who work with North Korea policies. Starting from Holsti’s (1970) national role conceptions and Weick’

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Title: HR Analytics for Competitive Advantage: Bringing organisational value while empowering the HR profession Authors: Elin Engsfelt & Louise Rosén Fång Supervisor: Rikard Larsson Problem definition: The HR profession has throughout history, and still has, a legitimacy problem, where the HR department typically becomes administrative support, rather than a strategic business partner. Purp

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The purpose of the thesis was to design a new rotor blade for the KTH test turbine according to present design guidelines for gas turbines manufactured at Siemens Industrial Turbomachinery in Finspång. Stage one of a real gas turbine was used as a reference for the aerodynamic design providing a starting point for the project. Using similar gas conditions the new rotor blade was optimized with reg

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This thesis studies the long-run performance of IPOs. In addition, it differentiates between family firms and non-family firms. The long-run performance is tested on listings on Nasdaq OMX Stockholm over a period from 1997 to 2011. The sample consists of 100 firms, whereas 39 firms are classified as family firms. To test the long-run IPO performance, buy-and-hold abnormal return over a three year

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This study investigates the path to high health spending among local governments in Indonesia under the setting where administrative, fiscal, and political decentralization are already in place. The motivation behind this study is that Indonesia still has low level of health outcomes. Small amount of health spending is one prominent reason for this lack of achievement. However, the effort in impro

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We live an increasingly larger part of our lives online. The Internet has fundamentally changed how we find information, buy products, connect with friends and find entertainment such as video streaming and digital distribution of books. The Internet has changed the competitive landscape for many markets. Local sellers suddenly face competition from sellers around the globe, introducing more choic

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Antioxidants are compounds present in plant, fruit, and vegetables, and they are known for their medicinal benefits such as anti-carcinogenic and anti-fungicidal activity. Most commonly used methods for extractions of such compounds are lengthy due to mass transfer limitations. This study proposes the use of carbon-dioxide expanded liquids (CXLs) as solvent to improve these limitations. Such solve

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Despite the worldwide importance of entrepreneurship, economic research on this topic has been only fragmented so far. Therefore, the goal of this study was firstly to find a common ground between the established neoclassical, endogenous and institutional growth frameworks on the one hand and the entrepreneurial school on the other hand. For this purpose the distinctive models developed by Solow,