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A new approach for ratiometric in vivo calcium imaging of microglia 1Scientific REPOrTS | 7: 6030 | DOI:10.1038/s41598-017-05952-3 www.nature.com/scientificreports A new approach for ratiometric in vivo calcium imaging of microglia Bianca Brawek1, Yajie Liang1, Daria Savitska1, Kaizhen Li1, Natalie Fomin-Thunemann1, Yury Kovalchuk1, Elizabeta Zirdum1, Johan Jakobsson   2 & Olga Garaschuk1 Microgli

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/publication_in_sci_rep.pdf - 2026-07-23

OBJECTIVE: To examine the expression pattern of matrix metalloproteinase-26 (MMP-26) mRNA and estrogen receptor-alpha (ER alpha) in normal, hyperplastic, premalignant and malignant endometrial tissue. DESIGN: Experimental study. SETTING: Department of Obstetrics and Gynecology of the Palacky University Medical School and University Hospital, Olomouc, Czech Republic, Department of Obstetrics and Gy

We show that the problem of constructing a minimum directed Steiner tree of depth O(log(d)n) in a directed graph of maximum outdegree d admits an expO(root logn)-approximation in polynomial time.

Popular Abstract in Swedish Växter får energi att växa till och fortplanta sig genom fotosyntes och cellandning. Vid fotosyntesen använder växterna ljusenergin från solen medan vid cellandningen kolföreningar bryts ner för att frigöra den energi som behövs till olika kemiska processerna i cellen. Enzymer är proteiner som katalyserar dessa kemiska processer. För att omvandla ett utgångsämne (t ex sMost cells are crowded with solutes, enzymes, nucleic acids, structural proteins and membranes. Crowding promotes macromolecular interactions and determines major properties of the cellular environment such as viscosity, diffusion and inhomogeneity. Macromolecular interactions that involve enzymes can affect the kinetic and regulatory properties of these, hence the interactions are part of the met

By counting the number of upcrossings of the mean level by a stationary Gaussian process one can estimate the mean frequency of the process. If the mean level is unknown and estimated from the observed mean level, then this crossing estimator is more or less biased, depending on the length of the observation interval. It is shown that if the interval is at least two mean wavelengths, then the bias

Direct electron transfer reactions of Bacillus halodurans bacterial multicopper oxidase on bare spectrographic graphite, as well as bare and thiol-modified gold electrodes were studied using cyclic voltammetry, potentiometry, amperometry, and spectroelectrochemistry. The redox potential of the T1 site of the enzyme was measured using mediatorless redox titration and found to be 325 mV +/- 10 mV vs

Exciton dynamics in alternating copolymer/fullerene solar cell blends have been investigated using femtosecond transient absorption spectroscopy. The acceptor concentrations have been varied over a wide range. Experimental data, kinetic modeling and simulations, all indicate that the efficiency of exciton conversion to charges is 100% even at acceptor concentrations as low as 20 wt%. The reported

Narrative is one method of tapping individual and collective memory where human experience is organized into temporally meaningful episodes and where a "point" is often made. In research projects that I have carried out about working life, "body stories" are often spontaneously related in making a "point." These stories exemplify "doing gender"-that is how gendered relations (that revolve around e

Concepts are an important element of the way international lawyers think and talk about international law. They materialise as conceptual terms, such as ‘jurisdiction’, ‘self-defence’ and ‘abuse of rights’. To enable a critical evaluation of international law and legal discourse, it is important that single instances of use of such terms be fully understood. This task presupposes a full recognitio

BACKGROUND: Hyperthyroidism is associated with alterations in metabolism that are currently only partially understood. The objective of the study was to investigate changes in metabolism associated with reinstatement of euthyroidism in Swedish patients.METHODS: Eighty metabolites in plasma were profiled from 10 subjects with Graves' disease (GD) at baseline and after 9 and 15 months of treatment t

Bit-error rate measurements for ON-OFF keying modulation at multigigabit per second rates over a V-band wireless link are presented. Serial data-rates from 2.5 to 20 Gb/s were studied for a 231-1 bit random sequence. Error-free data transfer over a 0.3-m link was achieved at up to 10 Gb/s. Acceptable bit-error rates, <10-5 and 10-3, were measured at up to 1.5 m for 10- and 15-Gb/s data-rate, respe

We present a model featuring heterogeneous households with a conspicuous consumptionmotive, in which inequality can decrease financial stability, and relate this behavior to the recent financial crisis in theUSA. A natural policy conclusion would be to combat income inequality jointly with financial instability by means of a progressive system of taxes and transfers. We investigate this for the ca

In very recent years, growing efforts have been devoted to the development of all-polymer solar cells (all-PSCs). One of the advantages of all-PSCs over the fullerene-based PSCs is the versatile design of both donor and acceptor polymers which allows the optimization of energy levels to maximize the open-circuit voltage (Voc). However, there is no successful example of all-PSCs with both high Voc

Growth theory is a controversial and topical subject in today’s debate since it’s in many contexts is seen as a potential solution on the reduction of poverty. There are several models that clarify the factors that contribute to a country’s economic growth. A commonly used model to describe countries that themselves are not seen as a driving force in the development of new technology is the techno

Since 2004 when mechanical exfoliation was first utilised to produce single layered samples of graphite, 2D materials have gained interest in the scientific community. With the prerequisite that the initial bulk material has a layered structure, these 2D materials have created an opportunity to examine materials on a very small scale as well as opening the possibility of creating smaller electrica