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Permanent exposure to pathogens requires decisions toward tolerance or immunity as a prime task of dendritic cells. The molecular mechanisms preventing uncontrolled immune responses are not completely clear. We investigated the regulatory function of Ncf1, an organizing protein of NADPH oxidase, in the signaling cascade of Toll-like receptors. TLR9-stimulated spleen cells from both Ncf1-deficient
This Letter presents a search for new resonances decaying to final states with a vector boson produced in association with a high transverse momentum photon, V gamma, with V = W(-> l nu) or Z(-> l(+)l(-)), where l = mu or mu. The measurements use 20.3fb(-1) of proton-proton collision data at a center-of-mass energy of root s = 8 TeV recorded with the ATLAS detector. No deviations from the Standard
Background: One of the main causes of mortality and morbidity following subarachnoid haemorrhage (SAH) is the development of cerebral vasospasm, a frequent complication arising in the weeks after the initial bleeding. Despite extensive research, to date no effective treatment of vasospasm exists. Prostacyclin is a potent vasodilator and inhibitor of platelet aggregation. In vitro models have shown
Abstract in UndeterminedRelevant source area of pollen (RSAP) and pollen productivity for 11 key taxa characteristic of the pasture woodland landscape of the Jura Mountains, Switzerland, were estimated using pollen assemblages from moss polsters at 20 sites. To obtain robust pollen productivity estimates (PPEs), we used vegetation survey data at a fine spatial-resolution (1 x 1 m(2)) and randomize
Background Today, dislocated femoral neck fractures are commonly treated with a cemented hip arthroplasty. However, cementing of the femoral component may lead to adverse effects and even death. Uncemented stems may lower these risks and hydroxyapatite (HA) coating may enhance integration, but prosthetic stability and clinical outcome in patients with osteoporotic bone have not been fully explored
Popular Abstract in Swedish Allt fler människor drabbas av cancer, som idag är den ledande dödsorsaken globalt. De vanligaste cancerformerna i världen är lungcancer, bröstcancer och tjocktarmscancer och det är störst risk att dö i lungcancer, levercancer och magcancer. Även i Sverige ökar antalet cancerfall, till stor del på grund av att vi lever allt längre och cancer är idag en av våra stora folCancer incidence is increasing and it is the number one cause of death worldwide. Cancer is a highly heterogeneous disease and there is a great need for new early diagnostic, prognostic and treatment predictive biomarkers in order to improve patient outcomes. The RNA-binding motif protein 3, RBM3, is an emerging candidate biomarker of favourable prognosis and treatment response in several types of
Accidents with vehicles happen more often than they should, whether it is by road traffic accidents or maritime accidents out in the sea. One big contributing factor is human error. Distraction, influence of alcohol/drugs, carelessness and speeding are examples of factors that can lead to severe injuries for the passengers, the surrounding people and to infrastructure. By transferring human maneuv
This study investigates the ethical and legal implications of artificial intelligence (AI) in the Swedish music industry, emphasizing the issues it presents to copyright law. As AI technologies progressively enable the automated generation of musical content, enduring legal principles such as authorship, ownership, and ethical rights are being questioned in ways that conventional copyright framewo
As decarbonization pressures increase for energy-intensive processing industries, understanding demand side readiness is essential in order to scale up breakthrough technologies. This thesis investigates the willingness to pay (WTP) for green steel in the North American automotive industry, with a focus on steel produced by the H2-DRI-EAF route, where hydrogen is produced from renewable electricit
When discussing urban planning and design, the focus often shifts toward large, overcrowded cities that require continuous improvements to remain competitive on the global economic map. However, smaller cities, while not classified as major metropolises, also play a significant role in urban development. These cities accommodate thousands of residents and have maintained their stability over the y
Employing a political ecology framework, this thesis explores Esrange Space Centre in the Swedish High North as a case for broader sociopolitical dynamics in which space infrastructure is increasingly intertwined with green transition and securitisation discourses. Through a Critical Discourse Analysis of three documents, informed by the concepts of capitalist catastrophism and sociotechnical imag
Background Drug use disorder (DUD) clusters in families due partly to shared environment, including sibling influences. Low academic achievement (AA) in adolescence increases DUD risk. This study examined whether low AA in an older sibling causally increases DUD risk in younger siblings. Methods We studied all Swedish full sibling pairs (n = 309,666) born 1972–1985 and ≤ 5 years apart. Older sibli
Scapolite-bearing orthogneisses underlying the Proterozoic Varena Iron Ore Deposit, eastern Lithuania, the western East European Craton, represent the development of a sodic alteration zone. Scapolite chemistry records fluid salinity increase with temperature, reaching its maximum at temperatures of ∼750 °C. Fluid-mineral reactions controlled the fluid KCl/NaCl ratio, enabling partial melting at p
OBJECTIVE: To determine whether probiotic prophylaxes reduce the odds of Clostridium difficile infection (CDI) in adults and children. DESIGN: Individual participant data (IPD) meta-analysis of randomized controlled trials (RCTs), adjusting for risk factors. METHODS: We searched 6 databases and 11 grey literature sources from inception to April 2016. We identified 32 RCTs (n=8,713); among them, 18
A search for strongly produced supersymmetric particles is conducted using signatures involving multiple energetic jets and either two isolated leptons (e or μ) with the same electric charge or at least three isolated leptons. The search also utilises b-tagged jets, missing transverse momentum and other observables to extend its sensitivity. The analysis uses a data sample of proton–proton collisi
Abstract: A search for a high-mass Higgs boson H is performed in the H → WW → ℓνℓν and H → WW → ℓνqq decay channels using pp collision data corresponding to an integrated luminosity of 20.3 fb−1 collected at s=8(Formula presented.) TeV by the ATLAS detector at the Large Hadron Collider. No evidence of a high-mass Higgs boson is found. Limits on σH × BR(H → WW) as a function of the Higgs boson mass
Although high-level evidence is currently lacking, noninferiority randomised controlled trials in predefined risk groups in non-muscle-invasive bladder cancer are under way to scientifically prove the safety of urinary biomarker-guided follow-up. To facilitate recommendations for clinical use, it is essential to comply with the EU certification for in vitro diagnostics and to demonstrate cost effe
A search is reported for long-lived dark photons with masses between 0.1 GeV and 15 GeV, from exotic decays of Higgs bosons produced via vector-boson-fusion. Events that contain displaced collimated Standard Model fermions reconstructed in the calorimeter or muon spectrometer are probed. This search uses the full LHC Run 2 (2015–2018) data sample collected in proton–proton collisions at s=13 TeV,
