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This study focuses on the intrinsically disordered regulatory domain of p53 and the impact of post-translational modifications. Through fully atomistic explicit water molecular dynamics simulations, we show the wealth of information and detailed understanding that can be obtained by varying the number of phosphorylated amino acids and implementing a restriction in the conformational entropy of the
Bragg coherent X-ray diffraction imaging (BCDI) has emerged as a powerful technique for strain imaging and morphology reconstruction of nanometre-scale crystals. However, BCDI often suffers from angular distortions that appear during data acquisition, caused by radiation pressure, heating or imperfect scanning stages. This limits the applicability of BCDI, in particular for small crystals and high
Abstract in UndeterminedThis paper is based on measurements obtained during a test of controlled islanding of part of the 50-kV grid in Southern Sweden. The purpose of the test was to verify operation of generator controls during islanding. The variations in voltage magnitude and frequency are shown as well as flicker severity and very-short variations. A number of performance indices have been ca
Fast and accurate collision detection between geometric bodies is essential in application areas like virtual reality, animation, simulation, games and robotics. In this work, we address the collision detection problem in applications where deformable bodies are used, which change their overall shape every time step of the simulation. We propose and evaluate suitable bounding volume trees for defo
The valence photoelectron spectra (PES) of gas-phase aminobenzoic acids (meta-, ortho- and para-isomers) were measured using synchrotron radiation and calculated from first principles using Density Functional Theory (DFT) with popular hybrid exchange-correlation functionals and many-body perturbation theory using the perturbative one-shot (G0W0) and eigenvalue self-consistent (GnW0) approaches wit
In clinical practice, the glomerular filtration rate (GFR), a measurement of kidney functioning, is normally calculated using equations, such as the European Kidney Function Consortium (EKFC) equation. Despite being the most general equation, EKFC, just like previously proposed approaches, can still struggle to achieve satisfactory performance, limiting its clinical applicability. As a possible so
There is an increasing need for new biomarkers to improve prediction of chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D). We aimed to identify blood-based epigenetic biomarkers associated with incident CKD and develop a methylation risk score (MRS) predicting CKD in individuals with newly diagnosed T2D. DNA methylation was analyzed epigenome wide in blood from 487 individuals
X-ray ptychography provides the highest resolution non-destructive imaging at synchrotron radiation facilities, and the efficiency of this method is crucial for coping with limited experimental time. Recent advancements in multi-beam ptychography have enabled larger fields of view, but spatial resolution for large 3D samples remains constrained by their thickness, requiring consideration of multip
Oxygen-defective metal oxides like cerium oxides exhibit giant electrostriction and field-induced piezoelectricity due to a dynamic electrosteric interplay between oxygen defects, V O ⋅ ⋅ , and the fluorite lattice. While such mechanisms are generally attributed to oxygen vacancies, recent results also highlight that trapped cationic defects, Ce Ce ′ , i.e. small polarons, can contribute to the el
Compositional heterogeneity is commonly observed in mixed bromide/iodide perovskite photoabsorbers, typically with minimal effects on charge carrier recombination and photovoltaic performance. Consistently, it has so far received very limited attention in bromide/chloride-mixed perovskites, which hold particular significance for blue light-emitting diodes. Here, we uncover that even a minor degree
Developing efficient and robust computational models is essential to improve our understanding of protein solution behavior. This becomes particularly important to tackle the high-concentration regime. In this context, the main challenge is to put forward coarse-grained descriptions able to reduce the level of detail, while retaining key features and relevant information. In this work, we develop
Disturbances on utilities, such as steam and cooling water, often cause large economic losses at industrial sites. Utilities are often shared between production areas, and a disturbance on a utility is therefore likely to affect a large part of the production site. In addition, production areas are often coupled by the product at the site. Obtaining a dynamic model of a site, with respect to utili
This study assesses the impacts of the floods in early 2011 in the Northern Cape Province in South Africa and focuses especially on the small town Keimoes located on the major Orange River. During this period 33 municipalities in 7 out of the country’s 8 provinces were declared as disaster areas due to widespread flooding. In Keimoes and the Northern Cape Province the flood impacts were widespread
Sedan 70-talet har tre olika läroplaner använts för att styra den svenska gymnasieskolan. Olika politiska styrningar och läroplansteoretiska influenser har gjort att dessa sett väldigt olika ut. I vårt arbete har vi jämfört kursplanerna för matematikämnet utifrån ett teoretiskt ramverk baserat på Basil Bernsteins begrepp om klassifikation och inramning. Förutom att jämföra gymnasiets kursplaner i Since the seventies, three different curriculums have been used to regulate the Swedish upper secondary school. Different political interests and influences from curriculum theory have made these look very different. In our study we have compared the different curricula used in mathematics using a theoretical framework based on Basil Bernstein's concepts classification and framing. In addition
In a time of globalization and increased international cooperation, the future of the nation state and nationalism is not obvious. International organizations, like the European Union (EU), are becoming more important and cooperation within the EU is constantly reaching new levels. EU is in some ways acting like a nation state and is trying to create a fellow-ship among the Member States for a str
Syftet med denna studie var att undersöka hur psykodynamiska psykoterapeuter upplevt den snabba omställningen från att ha fysiska samtal till digitala på grund av pandemin COVID-19, samt vilka erfarenheter de gjort. Semistrukturerade intervjuer genomfördes med fem psykodynamiska terapeuter. Materialet analyserades med tematisk analys och åtta teman identifierades. Studien visar att omställningen uThe purpose of this study was to determine how psychodynamic psychotherapists experienced the rapid transition from having psysical sessions to digital due to the pandemic COVID-19, as well as what experience they have had. Semi-structured interviews were conducted with five psychodynamic therapists. The material was analyzed with thematic analysis and eight themes were identified. The study shows
This project is focusing on one of the underlying issues within the plumbing industry (called “Värme Ventilation Sanitet” in Sweden). Strain injuries was the focus of this project to find a solution and discover the reasons to why these injuries keeps happening. The project then goes into a suggestion of which direction the industry might need to take to become better. Getting a solution to the in
För att kunna begränsa brandspridningen och bidra till brandskyddet delas en byggnad oftast in i brandceller. För att vid utrymning kunna ta sig till en säker plats kommer personerna som försöker ta sig ut troligtvis passera genom en öppning i brandcellsgräns. För att kunna bibehålla brandcellsgränsen trots användande av dörrar, fönster och andra öppningar finns det vissa krav på utformning av desIn most of the studies that are made for pedestrian flow through doors, reaserchers have just looked at the flow through oppenings without doors. This study aims to figure out how much impact the configuration of the door has on pedestrian flow. The configurations that have been examined are open doors, free swinging doors, doors that open inwards, doors that open outwards and the differences betw
The link between education and economic growth is thoroughly covered in the economic research literature. However, little emphasis has been put on the effect of female education particularly in Sub-Saharan Africa in This paper analyses the relationship between female educational attainment and economic growth for a panel of 28 Sub-Saharan countries in the time-period 1960 - 2010. Using a pooling e
