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We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic acid, eight triacylglycerol species, and lowered sphingomyelin 42:2;2 levels are predictive of faster progression towards insulin requirement. Of ~1,300 proteins examined in two

The association between pesticide exposure and non-Hodgkin lymphoma (NHL) including hairy cell leukemia (HCL) was analyzed in a pooled study of three case-control studies. Results on exposure to pesticides were based on 1,425 cases and 2,157 controls participating in the studies. Exposures were assessed by self-administered questionnaires completed as needed by phone. In the pooled univariate anal

Estimates of land-atmosphere exchanges of carbon, energy, water vapor, and other greenhouse gases based on the eddy covariance (EC) technique rely on the fundamental assumption that the flux footprint area is homogeneous. We investigated the impact of source area heterogeneity on flux estimates in single-level EC measurements over a managed boreal forest landscape. For this purpose, we compared si

The purpose of this study was to develop deeper knowledge about physicians’ lived experiences of breaking bad news by identifying their common meanings and inter-relatedness along with their potential alignment with process-oriented and relational aspects. Based on the methodology of descriptive phenomenology, in-depth interviews were conducted with 22 physicians from a wide variety of specialties

There have been previous studies comparing experimental methods for the purpose of capturing gaseous yields at a range of global equivalence ratios. However, no work has investigated the capability of the open controlled atmosphere cone calorimeter for collecting such data where its two modes of operation are directly compared. The aim of this study is to compare carbon monoxide yields collected u

This study is devoted to the calibration of a backpack radiation detection system (BPRDS) for evaluation of the external dose to a person staying in an environment contaminated by 137Cs. A commercially available portable gamma-ray spectrometer-dosemeter based on a NaI(Tl) detector was used. By means of information in the pulse-height distribution, it has been possible to separate the technogenic a

Background and aim: Research regarding patients undergoing total hip arthroplasty (THA) has shown no significant difference in postoperative pain with or without the use of local infiltration analgesia (LIA). The aim was to evaluate whether intra-operative LIA with Ropivacaine in patients undergoing THA under general anaesthesia reduces postoperative pain. Method: A randomised, placebo-controlled

BACKGROUND: The Redesigning Daily Occupations (ReDO™) work rehabilitation method has been found effective, compared with care as usual (CAU), for women with stress-related disorders. OBJECTIVE: To conduct a long-Term follow-up of former ReDO™ and CAU participants with respect to sick leave, well-being and everyday occupations 3-4 years after completed work rehabilitation. METHODS: Forty-Two women

Background: Adjuvant chemotherapy is standard treatment for other solid tumours, but to date has not proven effective in prostate cancer. Objective: o evaluate whether six cycles of docetaxel alone improve biochemical disease-free survival after radical prostatectomy for high-risk prostate cancer. Design, setting, and participants: Open-label, randomised multinational phase 3 trial. Enrolment of 4

A search is performed for new phenomena in events having a photon with high transverse momentum and a jet collected in 36.7fb-1 of proton–proton collisions at a centre-of-mass energy of s = 13 TeV recorded with the ATLAS detector at the Large Hadron Collider. The invariant mass distribution of the leading photon and jet is examined to look for the resonant production of new particles or the presen

CONTEXT: Statin use is associated with increased risk of type 2 diabetes and mild hyperglycemia. The underlying mechanisms are not well studied and the effect of statin treatment on GLP-1 secretion or production are unknown.OBJECTIVE: To assess the effects of rosuvastatin on GLP-1 secretion and production.METHODS: We performed association studies in the Malmö Diet and Cancer study cardiovascular c

BakgrundPrimärvården utgör den första linjen av vård och stöd för personer med psykisk ohälsa. Verksamheten är i huvudsak inriktad på diagnostik, medicinsk behandling och symtomlindring. Tillgången till denna vård upplevs emellertid som utmanande både av patienter och vårdgivare. En fördjupad förståelse av den levda erfarenheten av mötet med primärvården kan bidra till utvecklingen av mer individaBackground: Primary health care is in the unique position of being a first level of support and care to individuals with mental health problems. The focus in this service is on diagnosis, medical treatment, and symptom reduction. However, to access it is perceived as challenging by both patients and providers. An increased understanding of the lived experience of encountering primary health care m

BACKGROUND: Most COVID-19-related deaths and hospitalisations occurred among older people. Natural outdoor environments influence health outcomes, but the evidence of their effect on COVID-19 outcomes among older adults is limited. This study aimed to investigate associations between residential natural outdoor environment and COVID-19-related deaths or hospitalisations among community dwellers ag

Across different domains, justice is considered either from a perspective concerning mind-independent features of a situation or from a perspective related to mind-dependent motives, traits or emotions. Although these approaches have generated valuable insights, they remain largely disconnected from each other. What is missing is an integrative framework that can explain how the objective features

The International Monetary Fund (IMF) is a highly influential financial international organization that will be vital for the success of the Sustainable Development Goals (SDGs). While the IMF has been criticized by civil society actors for its negative impact on sustainable development, it is now focusing on supporting the SDGs. This support is particularly relevant when it comes to ensuring the

Objective: To investigate the dynamic changes of soluble fms-like tyrosine kinase−1 (sFlt−1), placental growth factor (PlGF) and their ratio in maternal plasma, from preeclampsia diagnosis to postpartum, evaluating its clinical utility. Methods: Single-center prospective longitudinal cohort study with repeated sample collection in women with established preeclampsia (PE). Seventy-five (n = 75) wom

The paper explores the role and meaning of maṣlaḥa (social utility) and its possible appropriation in the field of Islamic legal and economic thought, as laid down by various medieval and contemporary Muslim scholars. Questions that are pertinent to the research are the following: how has maṣlaḥa been incorporated in legal reasoning and what kind of meaning does it convey; what type of economic (a

Due to the large extent of seawater surface over the globe, aerosol particles spend significant time being transported over this type of surface. Therefore, global aerosol circulation is largely impacted by the processes particles undergo during long-range transport overseas. In this study, we investigated submicron aerosol (PM1) chemical composition changes during long-range transport events over